Down‐regulation of the cyclin‐dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis

Hui Guo, Li Jing, Yangzi Cheng, Vassilis Atsaves, Yi Lv, Tao Wu, Rujuan Su, Yamin Zhang, Ronghua Zhang, Wenbin Liu, George Z. Rassidakis, Yongchang Wei, Kejun Nan, Francois X. Claret – 25 November 2015 – Down‐regulation of p57 (KIP2) cyclin‐dependent kinase inhibitors accelerates the growth and invasion of hepatocellular carcinoma (HCC), suggesting that p57 may play an important role in liver carcinogenesis. However, the mechanism or oncogenic signal leading to p57 down‐regulation in HCC remains to be determined.

PI3K/AKT/mTOR‐dependent stabilization of oncogenic far‐upstream element binding proteins in hepatocellular carcinoma cells

Jana Samarin, Vibor Laketa, Mona Malz, Stephanie Roessler, Ilan Stein, Elad Horwitz, Stephan Singer, Eleni Dimou, Antonio Cigliano, Michaela Bissinger, Christine Susanne Falk, Xin Chen, Steven Dooley, Eli Pikarsky, Diego Francesco Calvisi, Carsten Schultz, Peter Schirmacher, Kai Breuhahn – 24 November 2015 – Transcription factors of the far‐upstream element‐binding protein (FBP) family represent cellular pathway hubs, and their overexpression in liver cancer (hepatocellular carcinoma [HCC]) stimulates tumor cell proliferation and correlates with poor prognosis.

Serial changes of cytokines and growth factors in peripheral circulation after right lobe donor hepatectomy

Shridhar Vasantrao Sasturkar, Paul David, Shreya Sharma, Shiv Kumar Sarin, Nirupama Trehanpati, Viniyendra Pamecha – 24 November 2015 – Cytokines and growth factors have prominent roles in liver regeneration. The aim of this study was to evaluate the biological markers of liver regeneration in healthy donors undergoing right lobe donor hepatectomy for living donor liver transplantation. Twenty‐five voluntary liver donors were enrolled. Peripheral blood samples were taken a day before the operation and on postoperative days (PODs) 1, 3, 7, 14, and 42.

Nonselective β‐blockers do not affect mortality in cirrhosis patients with ascites: Post Hoc analysis of three randomized controlled trials with 1198 patients

Lars Bossen, Aleksander Krag, Hendrik Vilstrup, Hugh Watson, Peter Jepsen – 24 November 2015 – The safety of nonselective β‐blockers (NSBBs) in advanced cirrhosis has been questioned. We used data from three satavaptan trials to examine whether NSBBs increase mortality in cirrhosis patients with ascites. The trials were conducted in 2006‐2008 and included 1198 cirrhosis patients with ascites followed for 1 year.

Recipient aging accelerates acquired transthyretin amyloidosis after domino liver transplantation

Yohei Misumi, Yasuko Narita, Toshinori Oshima, Mitsuharu Ueda, Taro Yamashita, Masayoshi Tasaki, Konen Obayashi, Kaori Isono, Yukihiro Inomata, Yukio Ando – 24 November 2015 – Domino liver transplantation (DLT) with liver grafts from patients with hereditary transthyretin (TTR) amyloidosis has been performed throughout the world because of a severe liver graft shortage. Reports of acquired systemic TTR amyloidosis in domino liver recipients have been increasing; however, the precise pathogenesis and clinical course of acquired TTR amyloidosis remains unclear.

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