Potential role of the donor in hepatocellular carcinoma recurrence after liver transplantation

Parsia A. Vagefi, Jennifer L. Dodge, Francis Y. Yao, John P. Roberts – 5 November 2014 – A subset of liver transplantation (LT) recipients who undergo transplantation for hepatocellular carcinoma (HCC) will develop postoperative recurrence. There has yet to be a thorough investigation of donor factors influencing recurrence.

The clinical course of cirrhosis: The importance of multistate models and competing risks analysis

Peter Jepsen, Hendrik Vilstrup, Per Kragh Andersen – 5 November 2014 – Multistate models are models of disease progression that, for a patient group, define multiple outcome events, each of which may affect the time to develop another outcome event. Multistate models are highly relevant for studies of patients with cirrhosis; both the classical perception of cirrhosis as either compensated or decompensated and the recent, more complex models of cirrhosis progression are multistate models.

Experience with molecular adsorbent recirculating system treatment in 20 children listed for high‐urgency liver transplantation

Willem S. Lexmond, Carin M. L. Van Dael, René Scheenstra, Joanne F. Goorhuis, Egbert Sieders, Henkjan J. Verkade, Patrick F. Van Rheenen, Martin Kömhoff – 4 November 2014 – For more than 10 years, children at our national center for pediatric liver transplantation (LT) have been treated with Molecular Adsorbent Recirculating System (MARS) liver dialysis as a bridging therapy to high‐urgency LT. Treatment was reserved for 20 patients with the highest degrees of hepatic encephalopathy (HE; median grade = 3.5).

Estimation of hepatitis C virus infections resulting from vertical transmission in Egypt

Lenka Benova, Susanne F. Awad, F. DeWolfe Miller, Laith J. Abu‐Raddad – 4 November 2014 – Despite having the highest hepatitis C virus (HCV) prevalence in the world, the ongoing level of HCV incidence in Egypt and its drivers are poorly understood. Whereas HCV mother‐to‐child infection is a well‐established transmission route, there are no estimates of HCV infections resulting from vertical transmission for any country, including Egypt. The aim of this study was to estimate the absolute number of new HCV infections resulting from vertical transmission in Egypt.

Immediate extubation after pediatric liver transplantation: A single‐center experience

Nora M. Fullington, Ryan P. Cauley, Kristina M. Potanos, Laura O'Melia, David Zurakowski, Heung Bae Kim, Christian Seefelder, Khashayar Vakili – 4 November 2014 – The care of pediatric liver transplant recipients has traditionally included postoperative mechanical ventilation. In 2005, we started extubating children undergoing liver transplantation in the operating room according to standard criteria for extubation used for general surgery cases. We reviewed our single‐center experience to determine our rates of immediate extubation and practice since that time.

Central nervous system complications after liver transplantation: Common but mostly transient phenomena

Martina Bernhardt, Henning Pflugrad, Annemarie Goldbecker, Hannelore Barg‐Hock, Wolfgang Knitsch, Jürgen Klempnauer, Christian P. Strassburg, Hartmut Hecker, Karin Weissenborn, Anita Blanka Tryc – 4 November 2014 – Although central nervous system complications (CNSCs) are common after orthotopic liver transplantation (OLT), standardized prospective studies are still lacking. This prospective study was aimed at determining the incidence of CNSCs, describing their clinical presentations, and establishing predicting factors.

Estimation of hepatitis C virus infections resulting from vertical transmission in Egypt

Lenka Benova, Susanne F. Awad, F. DeWolfe Miller, Laith J. Abu‐Raddad – 4 November 2014 – Despite having the highest hepatitis C virus (HCV) prevalence in the world, the ongoing level of HCV incidence in Egypt and its drivers are poorly understood. Whereas HCV mother‐to‐child infection is a well‐established transmission route, there are no estimates of HCV infections resulting from vertical transmission for any country, including Egypt. The aim of this study was to estimate the absolute number of new HCV infections resulting from vertical transmission in Egypt.

CCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation–induced cell death in hepatocellular carcinoma

Guo‐Dong Lu, Yang Huey Ang, Jing Zhou, Jegadeesan Tamilarasi, Benedict Yan, Yaw Chyn Lim, Supriya Srivastava, Manuel Salto‐Tellez, Kam M. Hui, Han‐Ming Shen, Long N. Nguyen, Bryan C. Tan, David L. Silver, Shing Chuan Hooi – 1 November 2014 – CCAAT enhancer binding protein α (C/EBPα) plays an essential role in cellular differentiation, growth, and energy metabolism. Here, we investigate the correlation between C/EBPα and hepatocellular carcinoma (HCC) patient outcomes and how C/EBPα protects cells against energy starvation.

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