CIDEC/FSP27 is regulated by peroxisome proliferator‐activated receptor alpha and plays a critical role in fasting‐ and diet‐induced hepatosteatosis

Cédric Langhi, Ángel Baldán – 21 November 2014 – The cell death‐inducing DNA fragmentation factor alpha‐like effector c (CIDEC; also known in rodents as FSP27 or fat‐specific protein 27) is a lipid droplet‐associated protein that promotes intracellular triglyceride (TAG) storage. CIDEC/Fsp27 is highly expressed in adipose tissue, but undetectable in normal liver. However, its hepatic expression rises during fasting or under genetic or diet‐induced hepatosteatosis in both mice and patients.

Cre‐ativity in the liver: Transgenic approaches to targeting hepatic nonparenchymal cells

Stephen N. Greenhalgh, Kylie P. Conroy, Neil C. Henderson – 21 November 2014 – Rapid evolution in transgenic (Tg) mouse technology now permits cell‐specific and temporal control of fluorescent cell‐labeling and gene inactivation. Here, we discuss the principal strategies that have been utilized to target, label, and manipulate hepatic nonparenchymal cells, with emphasis on the utility of constitutive and inducible Cre‐lox systems.

Development of risk scoring system for stratifying population for hepatocellular carcinoma screening

Yi‐Chun Hung, Chih‐Lin Lin, Chun‐Jen Liu, Hung Hung, Shi‐Ming Lin, Shou‐Dong Lee, Pei‐Jer Chen, Shu‐Chun Chuang, Ming‐Whei Yu – 21 November 2014 – The age and risk level that warrants hepatocellular carcinoma (HCC) screening remains to be defined. To develop risk scores for stratifying average‐risk population for mass HCC screening, we conducted a pooled analysis using data from three cohorts involving 12,377 Taiwanese adults 20‐80 years of age. During 191,240.3 person‐years of follow‐up, 387 HCCs occurred.

Cardiac tamponade following liver transplantation after intrapericardial control of the suprahepatic vena cava

Junming Xu, Johnny C. Hong, Ronald W. Busuttil – 19 November 2014 – Transabdominal intrapericardial control of the suprahepatic inferior vena cava (SIVC) is a rather uncommon procedure occasionally required in conjunction with complicated liver transplantation (LT) and hepatobiliary surgery. Experience with this technique is limited. Here we report 6 cases of LT in which transabdominal intrapericardial control of the SIVC was necessary.

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