Young‐Kyoung Lee, Byul A. Jee, So Mee Kwon, Young‐Sil Yoon, Wei Guang Xu, Hee‐Jung Wang, Xin Wei Wang, Snorri S. Thorgeirsson, Jae‐Seon Lee, Hyun Goo Woo, Gyesoon Yoon – 14 July 2015 – Many cancer cells require more glycolytic adenosine triphosphate production due to a mitochondrial respiratory defect. However, the roles of mitochondrial defects in cancer development and progression remain unclear.

Martha M. Kirstein, Frauke Metzler, Elena Geiger, Eyk Heinrich, Michael Hallensleben, Michael P. Manns, Arndt Vogel – 14 July 2015 – Autoimmune hepatitis (AIH) is a chronic inflammatory disease characterized by a loss of tolerance toward the hepatocellular epithelium. Liver transplantation (LT) represents the ultimate therapeutic option for a fulminant course or end‐stage liver disease. The aim of this study was to elucidate the clinical, serological, and genetic features of remission, relapse, and overall and LT‐free survival.

Patricia Marti, Claudia Stein, Tanja Blumer, Yann Abraham, Michael T. Dill, Monika Pikiolek, Vanessa Orsini, Giorgia Jurisic, Philippe Megel, Zuzanna Makowska, Claudia Agarinis, Luigi Tornillo, Tewis Bouwmeester, Heinz Ruffner, Andreas Bauer, Christian N. Parker, Tobias Schmelzle, Luigi M. Terracciano, Markus H. Heim, Jan S. Tchorz – 14 July 2015 – The Yes‐associated protein (YAP)/Hippo pathway has been implicated in tissue development, regeneration, and tumorigenesis. However, its role in cholangiocarcinoma (CC) is not established.

Polychronis Pavlidis, Jonathan Potts, Ashley Barnabas, Nigel Heaton, Ingvar Bjarnason, Michael Heneghan, Bu'Hussain Hayee – 14 July 2015

Caryn L. Elsegood, Chun Wei Chan, Mariapia A. Degli‐Esposti, Matthew E. Wikstrom, Alice Domenichini, Kyren Lazarus, Nico van Rooijen, Ruth Ganss, John K. Olynyk, George C.T. Yeoh – 14 July 2015 – Liver progenitor cells (LPCs) are necessary for repair in chronic liver disease because the remaining hepatocytes cannot replicate. However, LPC numbers also correlate with disease severity and hepatocellular carcinoma risk. Thus, the progenitor cell response in diseased liver may be regulated to optimize liver regeneration and minimize the likelihood of tumorigenesis.

Jasmohan S. Bajaj – 14 July 2015

Alexander G. Miethke, Wujuan Zhang, Julia Simmons, Amy E. Taylor, Tiffany Shi, Shiva Kumar Shanmukhappa, Rebekah Karns, Shana White, Anil G. Jegga, Celine S. Lages, Stephenson Nkinin, Bradley T. Keller, Kenneth D.R. Setchell – 14 July 2015 – Deficiency of multidrug resistance 2 (mdr2), a canalicular phospholipid floppase, leads to excretion of low‐phospholipid “toxic” bile causing progressive cholestasis. We hypothesize that pharmacological inhibition of the ileal, apical sodium‐dependent bile acid transporter (ASBT), blocks progression of sclerosing cholangitis in mdr2–/– mice.

Irwin Rosenberg, Elihu Schimmel – 14 July 2015

Jasmohan S. Bajaj – 14 July 2015

Alessandro Cucchetti, Lainie Friedman Ross, J. Richard Thistlethwaite, Alessandro Vitale, Matteo Ravaioli, Matteo Cescon, Giorgio Ercolani, Patrizia Burra, Umberto Cillo, Antonio Daniele Pinna – 14 July 2015 – A moral liver allocation policy must be fair. We considered a 2‐step, 2‐principle allocation system called “age mapping.” Its first principle, equal opportunity, ensures that candidates of all ages have an equal chance of getting an organ.