Chun‐Ju Chiang, Ya‐Wen Yang, Jin‐De Chen, San‐Lin You, Hwai‐I Yang, Mei‐Hsuan Lee, Mei‐Shu Lai, Chien‐Jen Chen – 5 December 2014 – A national viral hepatitis therapy program was launched in Taiwan in October 2003. This study aimed to assess the impact of the program on reduction of end‐stage liver disease (ESLD) burden. Profiles of national registries of households, cancers, and death certificates were used to derive incidence and mortality of ESLDs from 2000 to 2011.

Chahrazade Kantari‐Mimoun, Magali Castells, Ralph Klose, Anna‐Katharina Meinecke, Ursula J. Lemberger, Pierre‐Emmanuel Rautou, Hélène Pinot‐Roussel, Cécile Badoual, Katrin Schrödter, Christoph H. Österreicher, Joachim Fandrey, Christian Stockmann – 5 December 2014 – Angiogenesis is a key feature of liver fibrosis. Although sinusoidal remodeling is believed to contribute to fibrogenesis, the impact of sinusoidal angiogenesis on the resolution of liver fibrosis remains undefined.

Krasimira Aleksandrova, Tobias Pischon – 5 December 2014

Matthias Hardtke‐Wolenski, Richard Taubert, Fatih Noyan, Maren Sievers, Janine Dywicki, Jerome Schlue, Christine S. Falk, Brita Ardesjö Lundgren, Hamish S. Scott, Andreas Pich, Mark S. Anderson, Michael P. Manns, Elmar Jaeckel – 5 December 2014 – Autoimmune polyendocrine syndrome type 1 (APS‐1) is caused by mutations of the autoimmune regulator (AIRE) gene. Mouse studies have shown that this results in defective negative selection of T cells and defective early seeding of peripheral organs with regulatory T cells (Tregs).

M. Bishr Omary, Michael B. Wallace, Emad M. El‐Omar, Rajiv Jalan, Michael H. Nathanson – 5 December 2014

Guang Y. Li, Yun Zhou, Ruo S. Ying, Lei Shi, Yong Q. Cheng, Jun P. Ren, Jeddidiah W.D. Griffin, Zhan S. Jia, Chuan F. Li, Jonathan P. Moorman, Zhi Q. Yao – 5 December 2014 – T cells play a crucial role in viral clearance or persistence; however, the precise mechanisms that control their responses during viral infection remain incompletely understood. MicroRNA (miR) has been implicated as a key regulator controlling diverse biological processes through posttranscriptional repression.

David Paul, Ralf Bartenschlager – 5 December 2014

Mohammad Saeid Rezaee‐Zavareh, Mahdi Ramezani‐Binabaj, Seyed Moayed Alavian – 5 December 2014

Mathieu Sertorio, Xunya Hou, Rodrigo F.

Anna Gronert Álvarez, Paraskevi Fytili, Pothakamuri V. Suneetha, Anke R. M. Kraft, Christin Brauner, Jerome Schlue, Till Krech, Frank Lehner, Christoph Meyer‐Heithuis, Elmar Jaeckel, Juergen Klempnauer, Michael P. Manns, Markus Cornberg, Heiner Wedemeyer – 29 November 2014 – Regulatory T cells (Tregs) play an important role in controlling alloreactivity after solid organ transplantation, but they may also impair antiviral immunity.