Polychronis Pavlidis, Jonathan Potts, Ashley Barnabas, Nigel Heaton, Ingvar Bjarnason, Michael Heneghan, Bu'Hussain Hayee – 14 July 2015
Caryn L. Elsegood, Chun Wei Chan, Mariapia A. Degli‐Esposti, Matthew E. Wikstrom, Alice Domenichini, Kyren Lazarus, Nico van Rooijen, Ruth Ganss, John K. Olynyk, George C.T. Yeoh – 14 July 2015 – Liver progenitor cells (LPCs) are necessary for repair in chronic liver disease because the remaining hepatocytes cannot replicate. However, LPC numbers also correlate with disease severity and hepatocellular carcinoma risk. Thus, the progenitor cell response in diseased liver may be regulated to optimize liver regeneration and minimize the likelihood of tumorigenesis.
Jasmohan S. Bajaj – 14 July 2015
Alexander G. Miethke, Wujuan Zhang, Julia Simmons, Amy E. Taylor, Tiffany Shi, Shiva Kumar Shanmukhappa, Rebekah Karns, Shana White, Anil G. Jegga, Celine S. Lages, Stephenson Nkinin, Bradley T. Keller, Kenneth D.R. Setchell – 14 July 2015 – Deficiency of multidrug resistance 2 (mdr2), a canalicular phospholipid floppase, leads to excretion of low‐phospholipid “toxic” bile causing progressive cholestasis. We hypothesize that pharmacological inhibition of the ileal, apical sodium‐dependent bile acid transporter (ASBT), blocks progression of sclerosing cholangitis in mdr2–/– mice.
Irwin Rosenberg, Elihu Schimmel – 14 July 2015
Jasmohan S. Bajaj – 14 July 2015
Alessandro Cucchetti, Lainie Friedman Ross, J. Richard Thistlethwaite, Alessandro Vitale, Matteo Ravaioli, Matteo Cescon, Giorgio Ercolani, Patrizia Burra, Umberto Cillo, Antonio Daniele Pinna – 14 July 2015 – A moral liver allocation policy must be fair. We considered a 2‐step, 2‐principle allocation system called “age mapping.” Its first principle, equal opportunity, ensures that candidates of all ages have an equal chance of getting an organ.
Renato Romagnoli, Vincenzo Mazzaferro, Jordi Bruix – 14 July 2015
Edith M. Koehler, Elisabeth P.C. Plompen, Jeoffrey N.L. Schouten, Bettina E. Hansen, Sarwa Darwish Murad, Pavel Taimr, Frank W.G. Leebeek, Albert Hofman, Bruno H. Stricker, Laurent Castera, Harry L.A. Janssen – 14 July 2015 – Given that little is known about the prevalence of, and factors associated with, liver fibrosis in the general population, we aimed to investigate this in a large, well‐characterized cohort by means of transient elastography (TE). This study was part of the Rotterdam Study, a population‐based study among individuals ≥45 years.
Satoru Hagiwara, Naoshi Nishida, Masatoshi Kudo – 14 July 2015