Frédéric P. Lemaigre – 12 December 2014 – Slow renewal of the epithelial cells by proliferation ensures homeostasis of the liver, but extensive proliferation may occur upon injury. When proliferation is impaired, transdifferentiation of mature cells or differentiation of stem cells allows production of new hepatocytes and cholangiocytes. While lineage tracings using cyclization recombinase (Cre) recombinase–mediated cell labeling represent the gold standard for defining cell fate, there are more variables than was initially realized.

Juan Caballeria – 12 December 2014

Frédéric P. Lemaigre – 12 December 2014 – Slow renewal of the epithelial cells by proliferation ensures homeostasis of the liver, but extensive proliferation may occur upon injury. When proliferation is impaired, transdifferentiation of mature cells or differentiation of stem cells allows production of new hepatocytes and cholangiocytes. While lineage tracings using cyclization recombinase (Cre) recombinase–mediated cell labeling represent the gold standard for defining cell fate, there are more variables than was initially realized.

Jin‐xing Wei, Li‐hong Lv, Yun‐le Wan, Yang Cao, Guo‐lin Li, Hao‐ming Lin, Rui Zhou, Chang‐zhen Shang, Jun Cao, Hai He, Qing‐fang Han, Pei‐qing Liu, Gang Zhou, Jun Min – 12 December 2014 – The deregulation of microRNAs (miRNAs) plays an important role in human hepatocarcinogenesis. In this study, we highlight exosomes as mediators involved in modulating miRNA profiles in hepatocellular carcinoma (HCC) cells. First, we examined the different miRNA expression profiles in HCC cells and HCC cell–derived exosomes.

Beomseok Suh, Sehhoon Park, Dong Wook Shin, Jae Moon Yun, Hyung‐Kook Yang, Su Jong Yu, Cheong‐Il Shin, Jin‐Soo Kim, Eunmi Ahn, Hyejin Lee, Jin Ho Park, BeLong Cho – 12 December 2014 – Screening for hepatocellular carcinoma (HCC) is clinically important given that its early detection has remarkable survival benefits. We investigated the possible role of FIB‐4, a recently developed noninvasive marker for liver fibrosis based on routine laboratory tests, as a clinical indicator for predicting future HCC among hepatitis B surface antigen (HBsAg) carriers.

Renumathy Dhanasekaran, Ikuo Nakamura, Chunling Hu, Gang Chen, Abdul M. Oseini, Elif Sezin Seven, Alexander G. Miamen, Catherine D. Moser, Wei Zhou, Toin H. van Kuppevelt, Jan M. van Deursen, Taofic Mounajjed, Martin E. Fernandez‐Zapico, Lewis R. Roberts – 12 December 2014 – In vitro studies have proposed a tumor suppressor role for sulfatase 1 (SULF1) in hepatocellular carcinoma (HCC); however, high expression in human HCC has been associated with poor prognosis. The reason underlying this paradoxical observation remains to be explored.

Ann K. Daly, Christopher P. Day, Yang‐Lin Liu, Quentin M. Anstee – 12 December 2014

Beomseok Suh, Sehhoon Park, Dong Wook Shin, Jae Moon Yun, Hyung‐Kook Yang, Su Jong Yu, Cheong‐Il Shin, Jin‐Soo Kim, Eunmi Ahn, Hyejin Lee, Jin Ho Park, BeLong Cho – 12 December 2014 – Screening for hepatocellular carcinoma (HCC) is clinically important given that its early detection has remarkable survival benefits. We investigated the possible role of FIB‐4, a recently developed noninvasive marker for liver fibrosis based on routine laboratory tests, as a clinical indicator for predicting future HCC among hepatitis B surface antigen (HBsAg) carriers.

Imeke Goldschmidt, Katarina Migal, Norbert Rückert, Rolf Dick, Eva Doreen Pfister, Thomas Becker, Nicolas Richter, Frank Lehner, Ulrich Baumann – 11 December 2014 – Living related liver transplantation (LRLT) is a valuable transplant option for children with end‐stage liver disease who face long waiting times on regular waiting lists. The subjection of a healthy adult to a potentially life‐threatening operation can raise issues of freedom of choice, fear, and family conflict for the potential donors.

Hong‐Yuan Hsu, Mei‐Hwei Chang, Yen‐Hsuan Ni, Cheng‐Lun Chiang, Jia‐Feng Wu, Huey‐Ling Chen – 11 December 2014 – To determine whether universal infant immunization affects occult hepatitis B virus (HBV) infection (OBI), serum samples from hepatitis B surface antigen (HBsAg)‐negative subjects <18 years enrolled during six sequential seroepidemiological surveys conducted between 1984 (just before universal infant immunization) and 2009 were analyzed. Study subjects were divided into unvaccinated cohorts (born before 1984) and vaccinated cohorts (born after 1984).