Ubiquitin‐specific protease 7 accelerates p14ARF degradation by deubiquitinating thyroid hormone receptor‐interacting protein 12 and promotes hepatocellular carcinoma progression

Jia‐Bin Cai, Guo‐Ming Shi, Zhao‐Ru Dong, Ai‐Wu Ke, Hong‐Hui Ma, Qiang Gao, Zao‐Zhuo Shen, Xiao‐Yong Huang, Hao Chen, Ding‐Dang Yu, Li‐Xin Liu, Peng‐Fei Zhang, Chi Zhang, Mei‐Yu Hu, Liu‐Xiao Yang, Ying‐Hong Shi, Xiao‐Ying Wang, Zhen‐Bin Ding, Shuang‐Jian Qiu, Hui‐Chuan Sun, Jian Zhou, Yujiang G. Shi, Jia Fan – 29 December 2014 – The prognosis for hepatocellular carcinoma (HCC) remains dismal in terms of overall survival (OS), and its molecular pathogenesis has not been completely defined.

Sofosbuvir compassionate use program for patients with severe recurrent hepatitis C after liver transplantation

Xavier Forns, Michael Charlton, Jill Denning, John G. McHutchison, William T. Symonds, Diana Brainard, Theo Brandt‐Sarif, Paul Chang, Valerie Kivett, Lluís Castells, Martín Prieto, Robert J. Fontana, Thomas F. Baumert, Audrey Coilly, Maria Carlota Londoño, François Habersetzer – 29 December 2014 – Recurrent hepatitis C virus (HCV) infection after liver transplantation (LT) is associated with accelerated progression of liver disease, frequently leading to graft loss and early death.

Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: Findings and recommendations from an American Association for the Study of Liver Diseases–U.S. Food and Drug Administration Joint Workshop

Arun J. Sanyal, Scott L. Friedman, Arthur J. McCullough, Lara Dimick‐Santos – 29 December 2014 – Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease (CLD) in North America. It is a growing contributor to the burden of CDL requiring liver transplantation. Cirrhosis is also associated with an increased risk of hepatocellular cancer, which may occur even in the absence of cirrhosis in subjects with nonalcoholic steatohepatitis (NASH), the histological form of NAFLD associated with increased liver‐related mortality.

Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: Findings and recommendations from an American Association for the Study of Liver Diseases–U.S. Food and Drug Administration Joint Workshop

Arun J. Sanyal, Scott L. Friedman, Arthur J. McCullough, Lara Dimick‐Santos – 29 December 2014 – Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease (CLD) in North America. It is a growing contributor to the burden of CDL requiring liver transplantation. Cirrhosis is also associated with an increased risk of hepatocellular cancer, which may occur even in the absence of cirrhosis in subjects with nonalcoholic steatohepatitis (NASH), the histological form of NAFLD associated with increased liver‐related mortality.

Fifteen years and 382 extended right grafts from in situ split livers in a multicenter study: Are these still extended criteria liver grafts?

Umberto Maggi, Tullia M. De Feo, Enzo Andorno, Umberto Cillo, Luciano De Carlis, Michele Colledan, Patrizia Burra, Nicola De Fazio, Giorgio Rossi, on behalf of the Liver Transplantation and Intestine North Italy Transplant Study Group – 26 December 2014 – In situ split liver extended right grafts (SL‐ERGs) are still considered marginal grafts. Our aim was to verify this statement at the present time.

Voluntary organ donation system adapted to Chinese cultural values and social reality

Jiefu Huang, J. Michael Millis, Yilei Mao, M. Andrew Millis, Xinting Sang, Shouxian Zhong – 26 December 2014 – Organ donation and transplant systems have unique characteristics based on the local culture and socioeconomic context. China's transplant and organ donation systems developed without regulatory oversight until 2006 when regulation and policy were developed and then implemented over the next several years. Most recently, the pilot project of establishing a voluntary citizen‐based deceased donor program was established.

Surgically placed abdominal wall catheters on postoperative analgesia and outcomes after living liver donation

James Khan, Joel Katz, Janice Montbriand, Salima Ladak, Stuart McCluskey, Coimbatore Srinivas, Raynauld Ko, David Grant, Ashleene Bradbury, Yannick LeManach, Hance Clarke – 26 December 2014 – Living donor liver resections are associated with significant postoperative pain. Epidural analgesia is the gold standard for postoperative pain management, although it is often refused or contraindicated. Surgically placed abdominal wall catheters (AWCs) are a novel pain modality that can potentially provide pain relief for those patients who are unable to receive an epidural.

Analysis of ischemia/reperfusion injury in time‐zero biopsies predicts liver allograft outcomes

Jason M. Ali, Susan E. Davies, Rebecca J. Brais, Lucy V. Randle, John R. Klinck, Michael E. D. Allison, Yining Chen, Laura Pasea, Simon F. J. Harper, Gavin J. Pettigrew – 26 December 2014 – Ischemia/reperfusion injury (IRI) that develops after liver implantation may prejudice long‐term graft survival, but it remains poorly understood. Here we correlate the severity of IRIs that were determined by histological grading of time‐zero biopsies sampled after graft revascularization with patient and graft outcomes.

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