Caffeine ameliorates hemodynamic derangements and portosystemic collaterals in cirrhotic rats
Shao‐Jung Hsu, Fa‐Yauh Lee, Sun‐Sang Wang, I‐Fang Hsin, Te‐Yueh Lin, Hui‐Chun Huang, Ching‐Chih Chang, Chiao‐Lin Chuang, Hsin‐Ling Ho, Han‐Chieh Lin, Shou‐Dong Lee – 29 December 2014 – Portal hypertension (PH), a pathophysiological derangement of liver cirrhosis, is characterized by hyperdynamic circulation, angiogenesis, and portosystemic collaterals. These may lead to lethal complications, such as variceal bleeding. Caffeine has been noted for its effects on liver inflammation, fibrogenesis, and vasoreactiveness.