Ubiquitin‐specific protease 7 accelerates p14ARF degradation by deubiquitinating thyroid hormone receptor‐interacting protein 12 and promotes hepatocellular carcinoma progression

Jia‐Bin Cai, Guo‐Ming Shi, Zhao‐Ru Dong, Ai‐Wu Ke, Hong‐Hui Ma, Qiang Gao, Zao‐Zhuo Shen, Xiao‐Yong Huang, Hao Chen, Ding‐Dang Yu, Li‐Xin Liu, Peng‐Fei Zhang, Chi Zhang, Mei‐Yu Hu, Liu‐Xiao Yang, Ying‐Hong Shi, Xiao‐Ying Wang, Zhen‐Bin Ding, Shuang‐Jian Qiu, Hui‐Chuan Sun, Jian Zhou, Yujiang G. Shi, Jia Fan – 29 December 2014 – The prognosis for hepatocellular carcinoma (HCC) remains dismal in terms of overall survival (OS), and its molecular pathogenesis has not been completely defined.

Caffeine ameliorates hemodynamic derangements and portosystemic collaterals in cirrhotic rats

Shao‐Jung Hsu, Fa‐Yauh Lee, Sun‐Sang Wang, I‐Fang Hsin, Te‐Yueh Lin, Hui‐Chun Huang, Ching‐Chih Chang, Chiao‐Lin Chuang, Hsin‐Ling Ho, Han‐Chieh Lin, Shou‐Dong Lee – 29 December 2014 – Portal hypertension (PH), a pathophysiological derangement of liver cirrhosis, is characterized by hyperdynamic circulation, angiogenesis, and portosystemic collaterals. These may lead to lethal complications, such as variceal bleeding. Caffeine has been noted for its effects on liver inflammation, fibrogenesis, and vasoreactiveness.

Thrombolytic protocol minimizes ischemic‐type biliary complications in liver transplantation from donation after circulatory death donors

John B. Seal, Humberto Bohorquez, Trevor Reichman, Adam Kressel, Anand Ghanekar, Ari Cohen, Ian D. McGilvray, Mark S. Cattral, David Bruce, Paul Greig, Ian Carmody, David Grant, Markus Selzner, George Loss – 26 December 2014 – Liver transplantation (LT) with donation after circulatory death (DCD) donors has been associated with a high rate of ischemic‐type biliary strictures (ITBSs) and inferior graft survival.

Analysis of ischemia/reperfusion injury in time‐zero biopsies predicts liver allograft outcomes

Jason M. Ali, Susan E. Davies, Rebecca J. Brais, Lucy V. Randle, John R. Klinck, Michael E. D. Allison, Yining Chen, Laura Pasea, Simon F. J. Harper, Gavin J. Pettigrew – 26 December 2014 – Ischemia/reperfusion injury (IRI) that develops after liver implantation may prejudice long‐term graft survival, but it remains poorly understood. Here we correlate the severity of IRIs that were determined by histological grading of time‐zero biopsies sampled after graft revascularization with patient and graft outcomes.

Surgically placed abdominal wall catheters on postoperative analgesia and outcomes after living liver donation

James Khan, Joel Katz, Janice Montbriand, Salima Ladak, Stuart McCluskey, Coimbatore Srinivas, Raynauld Ko, David Grant, Ashleene Bradbury, Yannick LeManach, Hance Clarke – 26 December 2014 – Living donor liver resections are associated with significant postoperative pain. Epidural analgesia is the gold standard for postoperative pain management, although it is often refused or contraindicated. Surgically placed abdominal wall catheters (AWCs) are a novel pain modality that can potentially provide pain relief for those patients who are unable to receive an epidural.

Voluntary organ donation system adapted to Chinese cultural values and social reality

Jiefu Huang, J. Michael Millis, Yilei Mao, M. Andrew Millis, Xinting Sang, Shouxian Zhong – 26 December 2014 – Organ donation and transplant systems have unique characteristics based on the local culture and socioeconomic context. China's transplant and organ donation systems developed without regulatory oversight until 2006 when regulation and policy were developed and then implemented over the next several years. Most recently, the pilot project of establishing a voluntary citizen‐based deceased donor program was established.

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