Potential of human induced pluripotent stem cells in studies of liver disease

Fotios Sampaziotis, Charis‐Patricia Segeritz, Ludovic Vallier – 11 December 2014 – Liver disease is a leading cause of death in the Western world. However, our insight into the underlying disease mechanisms and the development of novel therapeutic agents has been hindered by limited availability of primary tissue, intraspecies variability associated with the use of animal models, and reduced long‐term viability of isolated and diseased liver cells.

Universal infant immunization and occult hepatitis B virus infection in children and adolescents: A population‐based study

Hong‐Yuan Hsu, Mei‐Hwei Chang, Yen‐Hsuan Ni, Cheng‐Lun Chiang, Jia‐Feng Wu, Huey‐Ling Chen – 11 December 2014 – To determine whether universal infant immunization affects occult hepatitis B virus (HBV) infection (OBI), serum samples from hepatitis B surface antigen (HBsAg)‐negative subjects <18 years enrolled during six sequential seroepidemiological surveys conducted between 1984 (just before universal infant immunization) and 2009 were analyzed. Study subjects were divided into unvaccinated cohorts (born before 1984) and vaccinated cohorts (born after 1984).

Personal decision‐making processes for living related liver transplantation in children

Imeke Goldschmidt, Katarina Migal, Norbert Rückert, Rolf Dick, Eva Doreen Pfister, Thomas Becker, Nicolas Richter, Frank Lehner, Ulrich Baumann – 11 December 2014 – Living related liver transplantation (LRLT) is a valuable transplant option for children with end‐stage liver disease who face long waiting times on regular waiting lists. The subjection of a healthy adult to a potentially life‐threatening operation can raise issues of freedom of choice, fear, and family conflict for the potential donors.

Subscribe to