Potential of human induced pluripotent stem cells in studies of liver disease
Fotios Sampaziotis, Charis‐Patricia Segeritz, Ludovic Vallier – 11 December 2014 – Liver disease is a leading cause of death in the Western world. However, our insight into the underlying disease mechanisms and the development of novel therapeutic agents has been hindered by limited availability of primary tissue, intraspecies variability associated with the use of animal models, and reduced long‐term viability of isolated and diseased liver cells.