Potential of human induced pluripotent stem cells in studies of liver disease

Fotios Sampaziotis, Charis‐Patricia Segeritz, Ludovic Vallier – 11 December 2014 – Liver disease is a leading cause of death in the Western world. However, our insight into the underlying disease mechanisms and the development of novel therapeutic agents has been hindered by limited availability of primary tissue, intraspecies variability associated with the use of animal models, and reduced long‐term viability of isolated and diseased liver cells.

Potential of human induced pluripotent stem cells in studies of liver disease

Fotios Sampaziotis, Charis‐Patricia Segeritz, Ludovic Vallier – 11 December 2014 – Liver disease is a leading cause of death in the Western world. However, our insight into the underlying disease mechanisms and the development of novel therapeutic agents has been hindered by limited availability of primary tissue, intraspecies variability associated with the use of animal models, and reduced long‐term viability of isolated and diseased liver cells.

Low‐molecular‐weight fibroblast growth factor 2 attenuates hepatic fibrosis by epigenetic down‐regulation of Delta‐like1

Ruo‐Lang Pan, Li‐Xin Xiang, Ping Wang, Xiao‐Yuan Liu, Li Nie, Wendong Huang, Jian‐Zhong Shao – 11 December 2014 – Liver fibrosis, a major cause of end‐stage liver diseases, is closely regulated by multiple growth factors and cytokines. The correlation of fibroblast growth factor 2 (FGF2) with chronic liver injury has been reported, but the exact functions of different FGF2 isoforms in liver fibrogenesis remain unclear.

Serum sodium and survival benefit of liver transplantation

Pratima Sharma, Douglas E. Schaubel, Nathan P. Goodrich, Robert M. Merion – 11 December 2014 – Hyponatremia is associated with elevated wait‐list mortality among end‐stage liver disease candidates for liver transplantation (LT). However, the effect of low serum sodium on the survival benefit of LT has not been examined. We sought to determine whether pretransplant hyponatremia is associated with an altered LT survival benefit. Data were obtained from the Scientific Registry of Transplant Recipients.

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