Andreia Carvalho, Ana Rocha, Luísa Lobato – 6 December 2014 – Hereditary transthyretin amyloidosis (ATTR) is a rare worldwide autosomal dominant disease caused by the systemic deposition of an amyloidogenic variant of transthyretin (TTR), which is usually derived from a single amino acid substitution in the TTR gene. More than 100 mutations have been described, with V30M being the most prevalent. Each variant has a different involvement, although peripheral neuropathy and cardiomyopathy are the most common.

Mathieu Sertorio, Xunya Hou, Rodrigo F.

Mohammad Saeid Rezaee‐Zavareh, Mahdi Ramezani‐Binabaj, Seyed Moayed Alavian – 5 December 2014

David Paul, Ralf Bartenschlager – 5 December 2014

Guang Y. Li, Yun Zhou, Ruo S. Ying, Lei Shi, Yong Q. Cheng, Jun P. Ren, Jeddidiah W.D. Griffin, Zhan S. Jia, Chuan F. Li, Jonathan P. Moorman, Zhi Q. Yao – 5 December 2014 – T cells play a crucial role in viral clearance or persistence; however, the precise mechanisms that control their responses during viral infection remain incompletely understood. MicroRNA (miR) has been implicated as a key regulator controlling diverse biological processes through posttranscriptional repression.

M. Bishr Omary, Michael B. Wallace, Emad M. El‐Omar, Rajiv Jalan, Michael H. Nathanson – 5 December 2014

Matthias Hardtke‐Wolenski, Richard Taubert, Fatih Noyan, Maren Sievers, Janine Dywicki, Jerome Schlue, Christine S. Falk, Brita Ardesjö Lundgren, Hamish S. Scott, Andreas Pich, Mark S. Anderson, Michael P. Manns, Elmar Jaeckel – 5 December 2014 – Autoimmune polyendocrine syndrome type 1 (APS‐1) is caused by mutations of the autoimmune regulator (AIRE) gene. Mouse studies have shown that this results in defective negative selection of T cells and defective early seeding of peripheral organs with regulatory T cells (Tregs).

Krasimira Aleksandrova, Tobias Pischon – 5 December 2014

Chahrazade Kantari‐Mimoun, Magali Castells, Ralph Klose, Anna‐Katharina Meinecke, Ursula J. Lemberger, Pierre‐Emmanuel Rautou, Hélène Pinot‐Roussel, Cécile Badoual, Katrin Schrödter, Christoph H. Österreicher, Joachim Fandrey, Christian Stockmann – 5 December 2014 – Angiogenesis is a key feature of liver fibrosis. Although sinusoidal remodeling is believed to contribute to fibrogenesis, the impact of sinusoidal angiogenesis on the resolution of liver fibrosis remains undefined.

Chun‐Ju Chiang, Ya‐Wen Yang, Jin‐De Chen, San‐Lin You, Hwai‐I Yang, Mei‐Hsuan Lee, Mei‐Shu Lai, Chien‐Jen Chen – 5 December 2014 – A national viral hepatitis therapy program was launched in Taiwan in October 2003. This study aimed to assess the impact of the program on reduction of end‐stage liver disease (ESLD) burden. Profiles of national registries of households, cancers, and death certificates were used to derive incidence and mortality of ESLDs from 2000 to 2011.