Cost‐effectiveness of strategies for testing current hepatitis C virus infection

Michael K. Chapko, D.Robert Dufour, Rikita I. Hatia, Jan Drobeniuc, John W. Ward, Chong‐Gee Teo – 30 June 2015 – Six strategies for identifying hepatitis C virus (HCV) viremia, involving testing for HCV antibody (HCVAb) followed by a nucleic acid test (NAT) for HCV RNA when the antibody test is positive, are compared. Decision analysis was used to determine mean relative cost per person tested and outcomes of HCV viremia detection. Parameters included proportions of test population with HCVAb and viremia plus specificity, sensitivity, and cost of individual tests.

PKC412 normalizes mutation‐related keratin filament disruption and hepatic injury in mice by promoting keratin–myosin binding

Raymond Kwan, Lu Chen, Koksun Looi, Guo‐Zhong Tao, Sujith V. Weerasinghe, Natasha T. Snider, Mary Anne Conti, Robert S. Adelstein, Qing Xie, M. Bishr Omary – 30 June 2015 – Keratins, among other cytoskeletal intermediate filament proteins, are mutated at a highly conserved arginine with consequent severe disease phenotypes due to disruption of keratin filament organization.

4′‐modified nucleoside analogs: Potent inhibitors active against entecavir‐resistant hepatitis B virus

Yuki Takamatsu, Yasuhito Tanaka, Satoru Kohgo, Shuko Murakami, Kamalendra Singh, Debananda Das, David J. Venzon, Masayuki Amano, Nobuyo Higashi‐Kuwata, Manabu Aoki, Nicole S. Delino, Sanae Hayashi, Satoru Takahashi, Yoshikazu Sukenaga, Kazuhiro Haraguchi, Stefan G. Sarafianos, Kenji Maeda, Hiroaki Mitsuya – 29 June 2015 – Certain nucleoside/nucleotide reverse transcriptase (RT) inhibitors (NRTIs) are effective against human immunodeficiency virus type 1 (HIV‐1) and hepatitis B virus (HBV).

Durability of small‐for‐size living donor allografts

Kin Pan Au, See Ching Chan, Kenneth Siu Ho Chok, Albert Chi Yan Chan, Tiffany Cho Lam Wong, William Wei Sharr, Chung Mau Lo – 29 June 2015 – Our aim was to study the long‐term outcomes of living donor liver transplantation using small‐for‐size (SFS) grafts. From July 2002 to July 2009, 233 patients received a right liver graft with a middle hepatic vein from a living donor in our center.

Subscribe to