Reply
Krasimira Aleksandrova, Tobias Pischon – 5 December 2014
Resolution of liver fibrosis requires myeloid cell–driven sinusoidal angiogenesis
Chahrazade Kantari‐Mimoun, Magali Castells, Ralph Klose, Anna‐Katharina Meinecke, Ursula J. Lemberger, Pierre‐Emmanuel Rautou, Hélène Pinot‐Roussel, Cécile Badoual, Katrin Schrödter, Christoph H. Österreicher, Joachim Fandrey, Christian Stockmann – 5 December 2014 – Angiogenesis is a key feature of liver fibrosis. Although sinusoidal remodeling is believed to contribute to fibrogenesis, the impact of sinusoidal angiogenesis on the resolution of liver fibrosis remains undefined.
Significant reduction in end‐stage liver diseases burden through the national viral hepatitis therapy program in Taiwan
Chun‐Ju Chiang, Ya‐Wen Yang, Jin‐De Chen, San‐Lin You, Hwai‐I Yang, Mei‐Hsuan Lee, Mei‐Shu Lai, Chien‐Jen Chen – 5 December 2014 – A national viral hepatitis therapy program was launched in Taiwan in October 2003. This study aimed to assess the impact of the program on reduction of end‐stage liver disease (ESLD) burden. Profiles of national registries of households, cancers, and death certificates were used to derive incidence and mortality of ESLDs from 2000 to 2011.
Inhibition of type I natural killer T cells by retinoids or following sulfatide‐mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice
Igor Maricic, Huiming Sheng, Idania Marrero, Ekihiro Seki, Tatiana Kisseleva, Som Chaturvedi, Natasha Molle, Stephanie A. Mathews, Bin Gao, Vipin Kumar – 5 December 2014 – Innate immune mechanisms leading to liver injury subsequent to chronic alcohol ingestion are poorly understood. Natural killer T (NKT) cells, enriched in the liver and comprised of at least two distinct subsets, type I and II, recognize different lipid antigens presented by CD1d molecules.
Issue in statistical strategy in case‐control study
Xiang‐Yong Li, Min‐Jun Bai, Lin‐Jun Chen, Jian‐Liang Xu, Zhi‐Huan Lin, Xing Li, Yan‐Fang Xing – 5 December 2014
Difference in Budd‐Chiari syndrome between the west and china
Xingshun Qi, Xiaozhong Guo, Daiming Fan – 5 December 2014
Dysregulated iron homeostasis is strongly associated with multiorgan failure and early mortality in acute‐on‐chronic liver failure
Jaswinder Singh Maras, Rakhi Maiwall, H.C. Harsha, Sukanta Das, Md.Shabir Hussain, Chandan Kumar, Chhagan Bihari, Archana Rastogi, Manoj Kumar, Nirupama Trehanpati, Shvetank Sharma, Akhilesh Pandey, Shiv Kumar Sarin – 5 December 2014 – Acute‐on‐chronic liver failure (ACLF) is an ailment with high incidence of multiorgan failure (MOF) and consequent mortality. Dysregulated iron homeostasis and macrophage dysfunction are linked to increased incidence of MOF.
Reply
Jian‐Gao Fan, Fu‐Sheng Wang – 5 December 2014
Comprehensive phenotyping of regulatory T cells after liver transplantation
Anna Gronert Álvarez, Paraskevi Fytili, Pothakamuri V. Suneetha, Anke R. M. Kraft, Christin Brauner, Jerome Schlue, Till Krech, Frank Lehner, Christoph Meyer‐Heithuis, Elmar Jaeckel, Juergen Klempnauer, Michael P. Manns, Markus Cornberg, Heiner Wedemeyer – 29 November 2014 – Regulatory T cells (Tregs) play an important role in controlling alloreactivity after solid organ transplantation, but they may also impair antiviral immunity.
Use of serial assessment of disease severity and liver biopsy for indication for liver transplantation in pediatric Epstein‐Barr virus–induced fulminant hepatic failure
Atsuko Nakazawa, Natsuko Nakano, Akinari Fukuda, Seisuke Sakamoto, Ken‐Ichi Imadome, Toyoichiro Kudo, Kentaro Matsuoka, Mureo Kasahara – 28 November 2014 – The decision to perform liver transplantation (LT) in patients with Epstein‐Barr virus (EBV)–induced fulminant hepatic failure (FHF) relies on a precise assessment of laboratory and pathological findings. In this study, we analyzed clinical and laboratory data as well as the pathological features of the liver in order to evaluate the pathogenesis and the need for LT in 5 patients with EBV‐induced FHF.