Chemokine (C‐X‐C motif) receptor 3–positive B cells link interleukin‐17 inflammation to protumorigenic macrophage polarization in human hepatocellular carcinoma

Rui‐Xian Liu, Yuan Wei, Qiu‐Hui Zeng, Ka‐Wo Chan, Xiao Xiao, Xiao‐Yu Zhao, Min‐Min Chen, Fang‐Zhu Ouyang, Dong‐Ping Chen, Limin Zheng, Xiang‐Ming Lao, Dong‐Ming Kuang – 1 August 2015 – B cells consistently represent abundant cellular components in tumors; however, direct evidence supporting a role for B cells in the immunopathogenesis of human cancers is lacking, as is specific knowledge of their trafficking mechanisms.

Fibroblast growth factor receptor 3 isoforms: Novel therapeutic targets for hepatocellular carcinoma?

Jakob Paur, Lisa Nika, Christiane Maier, Alexander Moscu‐Gregor, Julia Kostka, Daniela Huber, Thomas Mohr, Petra Heffeter, Waltraud C. Schrottmaier, Sonja Kappel, Daniela Kandioler, Klaus Holzmann, Brigitte Marian, Walter Berger, Michael Grusch, Bettina Grasl‐Kraupp – 1 August 2015 – Fibroblast growth factor receptors (FGFRs) are frequently up‐regulated in subsets of hepatocellular carcinoma (HCC). Here, we provide mechanistic insight that FGFR3 splice variants IIIb and IIIc impact considerably on the malignant phenotype of HCC cells.

Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi)

Shakeel M. Thakurdas, Mario F. Lopez, Shinako Kakuda, Rodrigo Fernandez‐Valdivia, Neda Zarrin‐Khameh, Robert S. Haltiwanger, Hamed Jafar‐Nejad – 1 August 2015 – Haploinsufficiency for the Notch ligand JAG1 in humans results in an autosomal‐dominant, multisystem disorder known as Alagille syndrome, which is characterized by a congenital cholangiopathy of variable severity.

De novo hepatic steatosis drives atherogenic risk in liver transplantation recipients

Michael O. Idowu, Ravi Chhatrala, M. Bilal Siddiqui, Carolyn Driscoll, R. Todd Stravitz, Arun J. Sanyal, Chandra Bhati, Carol Sargeant, Velimir A. Luketic, Richard K. Sterling, Melissa Contos, Scott Matherly, Puneet Puri, M. Shadab Siddiqui – 30 July 2015 – Nonalcoholic fatty liver disease is associated with cardiovascular disease (CVD) in the general population. Despite a high prevalence of de novo hepatic steatosis after liver transplantation (LT), there are no data exploring the association between hepatic steatosis after LT and atherogenic risk.

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