Thrombolytic protocol minimizes ischemic‐type biliary complications in liver transplantation from donation after circulatory death donors

John B. Seal, Humberto Bohorquez, Trevor Reichman, Adam Kressel, Anand Ghanekar, Ari Cohen, Ian D. McGilvray, Mark S. Cattral, David Bruce, Paul Greig, Ian Carmody, David Grant, Markus Selzner, George Loss – 26 December 2014 – Liver transplantation (LT) with donation after circulatory death (DCD) donors has been associated with a high rate of ischemic‐type biliary strictures (ITBSs) and inferior graft survival.

Analysis of ischemia/reperfusion injury in time‐zero biopsies predicts liver allograft outcomes

Jason M. Ali, Susan E. Davies, Rebecca J. Brais, Lucy V. Randle, John R. Klinck, Michael E. D. Allison, Yining Chen, Laura Pasea, Simon F. J. Harper, Gavin J. Pettigrew – 26 December 2014 – Ischemia/reperfusion injury (IRI) that develops after liver implantation may prejudice long‐term graft survival, but it remains poorly understood. Here we correlate the severity of IRIs that were determined by histological grading of time‐zero biopsies sampled after graft revascularization with patient and graft outcomes.

Surgically placed abdominal wall catheters on postoperative analgesia and outcomes after living liver donation

James Khan, Joel Katz, Janice Montbriand, Salima Ladak, Stuart McCluskey, Coimbatore Srinivas, Raynauld Ko, David Grant, Ashleene Bradbury, Yannick LeManach, Hance Clarke – 26 December 2014 – Living donor liver resections are associated with significant postoperative pain. Epidural analgesia is the gold standard for postoperative pain management, although it is often refused or contraindicated. Surgically placed abdominal wall catheters (AWCs) are a novel pain modality that can potentially provide pain relief for those patients who are unable to receive an epidural.

Voluntary organ donation system adapted to Chinese cultural values and social reality

Jiefu Huang, J. Michael Millis, Yilei Mao, M. Andrew Millis, Xinting Sang, Shouxian Zhong – 26 December 2014 – Organ donation and transplant systems have unique characteristics based on the local culture and socioeconomic context. China's transplant and organ donation systems developed without regulatory oversight until 2006 when regulation and policy were developed and then implemented over the next several years. Most recently, the pilot project of establishing a voluntary citizen‐based deceased donor program was established.

Fifteen years and 382 extended right grafts from in situ split livers in a multicenter study: Are these still extended criteria liver grafts?

Umberto Maggi, Tullia M. De Feo, Enzo Andorno, Umberto Cillo, Luciano De Carlis, Michele Colledan, Patrizia Burra, Nicola De Fazio, Giorgio Rossi, on behalf of the Liver Transplantation and Intestine North Italy Transplant Study Group – 26 December 2014 – In situ split liver extended right grafts (SL‐ERGs) are still considered marginal grafts. Our aim was to verify this statement at the present time.

Farnesoid X receptor–induced lysine‐specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity

Young‐Chae Kim, Sungsoon Fang, Sangwon Byun, Sunmi Seok, Byron Kemper, Jongsook Kim Kemper – 24 December 2014 – Bile acids (BAs) function as endocrine signaling molecules that activate multiple nuclear and membrane receptor signaling pathways to control fed‐state metabolism. Since the detergent‐like property of BAs causes liver damage at high concentrations, hepatic BA levels must be tightly regulated.

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