Risk factors for cytomegalovirus reactivation after liver transplantation: Can pre‐transplant cytomegalovirus antibody titers predict outcome?

Jackrapong Bruminhent, Charat Thongprayoon, Ross A. Dierkhising, Walter K. Kremers, Elitza S. Theel, Raymund R. Razonable – 17 January 2015 – Despite preexisting cytomegalovirus (CMV) immunity, CMV‐seropositive liver transplantation (LT) patients remain at risk of CMV infection. We hypothesized that the pre‐transplant CMV antibody titer correlates with the risk of CMV reactivation. We conducted a retrospective study of CMV‐seropositive LT recipients who did not receive anti‐CMV prophylaxis from 2007 to 2013.

Use of model for end‐stage liver disease exceptions for donation after cardiac death graft recipients relisted for liver transplantation

Richard C. Maduka, Peter L. Abt, David S. Goldberg – 17 January 2015 – Donation after cardiac death (DCD) liver transplantation is associated with increased biliary complications and graft failure. Yet for unclear reasons, DCD recipients relisted for transplantation have lower wait‐list mortality than other retransplant candidates.

A clinicopathological cohort study of liver pathology in 301 patients with human immunodeficiency virus/acquired immune deficiency syndrome

Mark W. Sonderup, Helen Wainwright, Pauline Hall, Henry Hairwadzi, C. Wendy N. Spearman – 16 January 2015 – Liver disease complicates human immunodeficiency virus (HIV)/acquired immune deficiency syndrome; however, liver pathology data are limited, particularly from high HIV prevalence countries. We investigated the spectrum and clinicopathological correlates of liver pathology in a high HIV burden setting.

Hepatocyte buds derived from progenitor cells repopulate regions of parenchymal extinction in human cirrhosis

Ashley E. Stueck, Ian R. Wanless – 16 January 2015 – Repair of cirrhotic livers occurs, in part, by repopulation with hepatocytes through the stem/progenitor pathway. There remain many uncertainties regarding this pathway. Hepatocyte “buds” occurring in broad septa are hypothesized to be the anatomic manifestation of this pathway. Our purpose was to define a morphologic sequence of bud maturation to allow a quantitative measure of the importance of the stem/progenitor pathway in humans.

Terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: A randomized trial

Marta Cavallin, Patrick S. Kamath, Manuela Merli, Silvano Fasolato, Pierluigi Toniutto, Francesco Salerno, Mauro Bernardi, Roberto Giulio Romanelli, Cosimo Colletta, Freddy Salinas, Antonio Di Giacomo, Lorenzo Ridola, Ezio Fornasiere, Paolo Caraceni, Filippo Morando, Salvatore Piano, Angelo Gatta, Paolo Angeli, for the Italian Association for the Study of the Liver Study Group on Hepatorenal Syndrome – 16 January 2015 – Hepatorenal syndrome (HRS), a serious complication of cirrhosis, is associated with high mortality without treatment.

Attenuated portal hypertension in germ‐free mice: Function of bacterial flora on the development of mesenteric lymphatic and blood vessels

Sheida Moghadamrad, Kathy D. McCoy, Markus B. Geuking, Hans Sägesser, Jorum Kirundi, Andrew J. Macpherson, Andrea De Gottardi – 16 January 2015 – Intestinal bacterial flora may induce splanchnic hemodynamic and histological alterations that are associated with portal hypertension (PH). We hypothesized that experimental PH would be attenuated in the complete absence of intestinal bacteria. We induced prehepatic PH by partial portal vein ligation (PPVL) in germ‐free (GF) or mice colonized with altered Schaedler's flora (ASF).

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