Liver alkaline phosphatase: A missing link between choleresis and biliary inflammation

Raoul Poupon – 20 January 2015 – Several lines of evidence show that serum alkaline phosphatase (AP) is not only a signpost of cholestasis but also a surrogate marker of the severity of primary biliary cirrhosis and primary sclerosing cholangitis. In the present opinion article, we review and discuss the putative role of liver AP in health and in cholestatic diseases.

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