The significance of nonobstructive sinusoidal dilatation of the liver: Impaired portal perfusion or inflammatory reaction syndrome

Chiara Marzano, Dominique Cazals‐Hatem, Pierre‐Emmanuel Rautou, Dominique‐Charles Valla – 13 February 2015 – Sinusoidal dilatation found in the absence of an impaired sinusoidal blood outflow has been so far of unclear significance. Sinusoidal dilatation may actually be a nonspecific feature of impaired portal venous blood inflow, whatever the cause, or a feature of severe systemic inflammatory reaction syndrome, whatever the cause. Sinusoidal dilatation is mainly located in the centrilobular area even in the absence of an outflow block.

The significance of nonobstructive sinusoidal dilatation of the liver: Impaired portal perfusion or inflammatory reaction syndrome

Chiara Marzano, Dominique Cazals‐Hatem, Pierre‐Emmanuel Rautou, Dominique‐Charles Valla – 13 February 2015 – Sinusoidal dilatation found in the absence of an impaired sinusoidal blood outflow has been so far of unclear significance. Sinusoidal dilatation may actually be a nonspecific feature of impaired portal venous blood inflow, whatever the cause, or a feature of severe systemic inflammatory reaction syndrome, whatever the cause. Sinusoidal dilatation is mainly located in the centrilobular area even in the absence of an outflow block.

Improvement of predictive models of risk of disease progression in chronic hepatitis C by incorporating longitudinal data

Monica A. Konerman, Yiwei Zhang, Ji Zhu, Peter D.R. Higgins, Anna S.F. Lok, Akbar K. Waljee – 12 February 2015 – Existing predictive models of risk of disease progression in chronic hepatitis C have limited accuracy. The aim of this study was to improve upon existing models by applying novel statistical methods that incorporate longitudinal data. Patients in the Hepatitis C Antiviral Long‐term Treatment Against Cirrhosis trial were analyzed.

Changing hepatitis D virus epidemiology in a hepatitis B virus endemic area with a national vaccination program

Hsi‐Hsun Lin, Susan Shin‐Jung Lee, Ming‐Lung Yu, Ting‐Tsung Chang, Chien‐Wei Su, Bor‐Shen Hu, Yaw‐Sen Chen, Chun‐Kai Huang, Chung‐Hsu Lai, Jiun‐Nong Lin, Jaw‐Ching Wu – 11 February 2015 – The emergence of hepatitis D virus (HDV) infection in the era of widespread HBV vaccination has not been described before. We aimed to investigate the changing epidemiology of HDV infection among high‐ and low‐risk populations after an outbreak of human immunodeficiency virus (HIV) infection among injection drug users (IDUs) in Taiwan.

Complications and competing risks of death in compensated viral cirrhosis (ANRS CO12 CirVir prospective cohort)

Jean‐Claude Trinchet, Valérie Bourcier, Cendrine Chaffaut, Mohand Ait Ahmed, Setty Allam, Patrick Marcellin, Dominique Guyader, Stanislas Pol, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean‐Pierre Bronowicki, Jean‐Pierre Zarski, Odile Goria, Paul Calès, Jean‐Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Jean‐Frédéric Blanc, Armand Abergel, Lawrence Serfaty, Ariane Mallat, Jean‐Didier Grangé, Catherine Buffet, Yannick Bacq, Claire Wartelle, Thông Dao, Yves Benhamou, Christophe Pilette, Christine Silvain, Christos Christ

The role of hepatic resection in the treatment of hepatocellular cancer

Sasan Roayaie, Ghalib Jibara, Parissa Tabrizian, Joong‐Won Park, Jijin Yang, Lunan Yan, Myron Schwartz, Guohong Han, Francesco Izzo, Mishan Chen, Jean‐Frédéric Blanc, Philip Johnson, Masatoshi Kudo, Lewis R. Roberts, Morris Sherman – 11 February 2015 – Current guidelines recommend surgical resection as the primary treatment for a single hepatocellular cancer (HCC) with Child's A cirrhosis, normal serum bilirubin, and no clinically significant portal hypertension. We determined how frequently guidelines were followed and whether straying from them impacted survival.

Cost‐effectiveness of hepatitis C treatment for patients in early stages of liver disease

Andrew J. Leidner, Harrell W. Chesson, Fujie Xu, John W. Ward, Philip R. Spradling, Scott D. Holmberg – 11 February 2015 – New treatments for hepatitis C virus (HCV) may be highly effective but are associated with substantial costs that may compel clinicians and patients to consider delaying treatment. This study investigated the cost‐effectiveness of these treatments with a focus on patients in early stages of liver disease.

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