Augmented Wnt signaling as a therapeutic tool to prevent ischemia/reperfusion injury in liver: Preclinical studies in a mouse model

Bowen Liu, Rong Zhang, Guozhong Tao, Nadja Corinna Lehwald, Bo Liu, Yangseok Koh, Karl G. Sylvester – 3 September 2015 – The Wnt signaling pathway has established biological roles in liver development, regeneration, and carcinogenesis. Given the common need for cellular energy utilization in each of these processes, we hypothesized that Wnt signaling would directly regulate hepatocyte mitochondrial function. Mice were engineered to overexpress Wnt1 in hepatocytes under the control of a tetracycline analogue.

Exendin‐4 attenuates brain death–induced liver damage in the rat

Rodrigo Carlessi, Natalia E. Lemos, Ana L. Dias, Leticia A. Brondani, Jarbas R. Oliveira, Andrea C. Bauer, Cristiane B. Leitão, Daisy Crispim – 3 September 2015 – The majority of liver grafts destined for transplantation originate from brain dead donors. However, significantly better posttransplantation outcomes are achieved when organs from living donors are used, suggesting that brain death (BD) causes irreversible damage to the liver tissue. Recently, glucagon‐like peptide‐1 (GLP1) analogues were shown to possess interesting hepatic protection effects in different liver disease models.

Emergence of linezolid resistance in hepatobiliary infections caused by Enterococcus faecium

Marc Niebel, M. Thamara P. R. Perera, Tahir Shah, Ravi Marudanayagam, Kate Martin, Beryl A. Oppenheim, Miruna D. David – 3 September 2015 – Enterococcal infections are common in liver transplantation and hepatopancreaticobiliary (HPB) surgery. Linezolid is frequently used to treat not only vancomycin‐resistant Enterococcus (VRE), but also vancomycin‐sensitive Enterococcus (VSE) infections, and resistance can develop.

Keeping high model for end‐stage liver disease score liver transplantation candidates alive

Jacqueline G. O'Leary, Susan L. Orloff, Josh Levitsky, Paul Martin, David P. Foley – 3 September 2015 – As the mean Model for End‐Stage Liver Disease (MELD) score at time of liver transplantation continues to increase, it is crucial to implement preemptive strategies to reduce wait‐list mortality. We review the most common complications that arise in patients with a high MELD score in an effort to highlight strategies that can maximize survival and successful transplantation. Liver Transpl 21:1428‐1437, 2015. © 2015 AASLD.

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