Systems biological analyses reveal the hepatitis C virus (HCV)‐specific regulation of hematopoietic development

Victoria M. Velazquez, Luke S. Uebelhoer, Manoj Thapa, Chris C. Ibegbu, Cynthia Courtney, Steven E. Bosinger, Joseph F. Magliocca, Andrew B. Adams, Allan D. Kirk, Stuart J. Knechtle, Daniel Kalman, Mehul S. Suthar, Arash Grakoui – 21 October 2014 – Chronic liver disease is characterized by the liver enrichment of myeloid dendritic cells (DCs). To assess the role of disease on myelopoiesis, we utilized a systems biology approach to study development in liver‐resident cells expressing stem cell marker CD34.

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Patrick Starlinger, Mickael Lesurtel, Christine Brostjan, Pierre‐Alain Clavien, Thomas Gruenberger – 21 October 2014

Management of bleeding and transfusion during liver transplantation before and after the introduction of a rotational thromboelastometry–based algorithm

Stéphanie Roullet, Geneviève Freyburger, Maximilien Cruc, Alice Quinart, Laurent Stecken, Magali Audy, Laurence Chiche, François Sztark – 20 October 2014 – Orthotopic liver transplantation (OLT) remains a potentially hemorrhagic procedure. Rotational thromboelastometry (ROTEM) is a point‐of‐care device used to monitor coagulation during OLT. Whether it allows blood loss and transfusions to be reduced during OLT remains controversial. Excellent correlations and predictive values have been found between ROTEM parameters and fibrinogen.

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