Is Systemic heparinization necessary during living donor hepatectomy?

Joo Dong Kim, Dong Lak Choi, Young Seok Han – 28 October 2014 – Systemic heparinization has traditionally been performed during living donor hepatectomy (LDH) at most transplant centers because of the possibility of graft vascular thrombosis. However, no consensus on the use of systemic heparinization during LDH has yet emerged. The aims of the present study were to compare donor and recipient outcomes with reference to systemic heparinization and to determine whether or not systemic heparin needs to be administered to living donors.

The continuum of hepatitis C testing and care

Kendra Viner, Danica Kuncio, E. Claire Newbern, Caroline C. Johnson – 28 October 2014 – A hepatitis C virus (HCV)‐infected person will ideally have access to quality health care and move through the HCV continuum of care (CoC) from HCV antibody (Ab) screening, HCV‐RNA confirmation, engagement and retention in medical care, and treatment. Unfortunately, studies show that many patients do not progress through this continuum. Because these studies may not be generalizable, we assessed the HCV CoC in Philadelphia from January 2010 to December 2013 at the population level.

Adding pegylated interferon to entecavir for hepatitis B e antigen–positive chronic hepatitis B: A multicenter randomized trial (ARES study)

Willem Pieter Brouwer, Qing Xie, Milan J. Sonneveld, Ningping Zhang, Qin Zhang, Fehmi Tabak, Adrian Streinu‐Cercel, Ji‐Yao Wang, Ramazan Idilman, Hendrik W. Reesink, Mircea Diculescu, Krzysztof Simon, Mihai Voiculescu, Meral Akdogan, Wlodzimierz Mazur, Jurrien G.P. Reijnders, Elke Verhey, Bettina E. Hansen, Harry L.A. Janssen, for the ARES Study Group – 28 October 2014 – Entecavir (ETV) is a potent inhibitor of hepatitis B viral replication, but long‐term therapy may be required.

Crucial roles of mixed‐lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice

Dae‐Hwan Kim, Jennifer Chiyeon Rhee, Sujeong Yeo, Rongkun Shen, Soo‐Kyung Lee, Jae W. Lee, Seunghee Lee – 25 October 2014 – The histone H3‐lysine‐4 methyltransferase mixed‐lineage leukemia 3 (MLL3) and its closest homolog, MLL4 (aka KMT2D), belong to two homologous transcriptional coactivator complexes, named MLL3 and MLL4 complexes, respectively. MLL3 plays crucial roles in multiple metabolic processes. However, the physiological roles of MLL4 in metabolism and the relationship between MLL3 and MLL4 in metabolic gene regulation are unclear.

Retinoic acid‐related orphan receptor alpha reprograms glucose metabolism in glutamine‐deficient hepatoma cells

Jun‐Kyu Byun, Yeon‐Kyung Choi, Yu Na Kang, Byoung Kuk Jang, Koo Jeong Kang, Yong Hyun Jeon, Ho‐Won Lee, Jae‐Han Jeon, Seung‐Hoi Koo, Won‐Il Jeong, Robert A. Harris, In‐Kyu Lee, Keun‐Gyu Park – 25 October 2014 – The metabolism of glutamine and glucose is recognized as a promising therapeutic target for the treatment of cancer; however, targeted molecules that mediate glutamine and glucose metabolism in cancer cells have not been addressed.

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