Conjugated bile acid–activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression

Masayuki Nagahashi, Kazuaki Takabe, Runping Liu, Kesong Peng, Xiang Wang, Yun Wang, Nitai C. Hait, Xuan Wang, Jeremy C. Allegood, Akimitsu Yamada, Tomoyoshi Aoyagi, Jie Liang, William M. Pandak, Sarah Spiegel, Phillip B. Hylemon, Huiping Zhou – 1 November 2014

Adding pegylated interferon to entecavir for hepatitis B e antigen–positive chronic hepatitis B: A multicenter randomized trial (ARES study)

Willem Pieter Brouwer, Qing Xie, Milan J. Sonneveld, Ningping Zhang, Qin Zhang, Fehmi Tabak, Adrian Streinu‐Cercel, Ji‐Yao Wang, Ramazan Idilman, Hendrik W. Reesink, Mircea Diculescu, Krzysztof Simon, Mihai Voiculescu, Meral Akdogan, Wlodzimierz Mazur, Jurrien G.P. Reijnders, Elke Verhey, Bettina E. Hansen, Harry L.A. Janssen, for the ARES Study Group – 28 October 2014 – Entecavir (ETV) is a potent inhibitor of hepatitis B viral replication, but long‐term therapy may be required.

The continuum of hepatitis C testing and care

Kendra Viner, Danica Kuncio, E. Claire Newbern, Caroline C. Johnson – 28 October 2014 – A hepatitis C virus (HCV)‐infected person will ideally have access to quality health care and move through the HCV continuum of care (CoC) from HCV antibody (Ab) screening, HCV‐RNA confirmation, engagement and retention in medical care, and treatment. Unfortunately, studies show that many patients do not progress through this continuum. Because these studies may not be generalizable, we assessed the HCV CoC in Philadelphia from January 2010 to December 2013 at the population level.

Is Systemic heparinization necessary during living donor hepatectomy?

Joo Dong Kim, Dong Lak Choi, Young Seok Han – 28 October 2014 – Systemic heparinization has traditionally been performed during living donor hepatectomy (LDH) at most transplant centers because of the possibility of graft vascular thrombosis. However, no consensus on the use of systemic heparinization during LDH has yet emerged. The aims of the present study were to compare donor and recipient outcomes with reference to systemic heparinization and to determine whether or not systemic heparin needs to be administered to living donors.

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