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In autoimmune hepatitis type 1 or the autoimmune hepatitis–sclerosing cholangitis variant defective regulatory T‐cell responsiveness to IL‐2 results in low IL‐10 production and impaired suppression

Read more about In autoimmune hepatitis type 1 or the autoimmune hepatitis–sclerosing cholangitis variant defective regulatory T‐cell responsiveness to IL‐2 results in low IL‐10 production and impaired suppression

Rodrigo Liberal, Charlotte R. Grant, Beth S. Holder, John Cardone, Marc Martinez‐Llordella, Yun Ma, Michael A. Heneghan, Giorgina Mieli‐Vergani, Diego Vergani, Maria Serena Longhi – 8 May 2015 – Defective immune regulation plays a permissive role enabling effector cells to initiate and perpetuate tissue damage, eventually resulting in autoimmune disease. Numerical and functional regulatory T‐cell (Treg) impairment has been previously reported in autoimmune liver disease (AILD; including autoimmune hepatitis and autoimmune sclerosing cholangitis ASC).

The BH3‐only protein BID impairs the p38‐mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice

Read more about The BH3‐only protein BID impairs the p38‐mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice

Johanna Orlik, Sven Schüngel, Laura Elisa Buitrago‐Molina, Silke Marhenke, Robert Geffers, Jessica Endig, Katharina Lobschat, Stephanie Rössler, Benjamin Goeppert, Michael P. Manns, Atan Gross, Arndt Vogel – 8 May 2015 – Apoptosis is critical for maintaining tissue homeostasis, and apoptosis evasion is considered as a hallmark of cancer. However, increasing evidence also suggests that proapoptotic molecules can contribute to the development of cancer, including liver cancer.