Dysbiosis‐induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice

Peng Chen, Peter Stärkel, Jerrold R. Turner, Samuel B. Ho, Bernd Schnabl – 24 September 2014 – Intestinal barrier dysfunction is an important contributor to alcoholic liver disease (ALD). Translocated microbial products trigger an inflammatory response in the liver and contribute to steatohepatitis. Our aim was to investigate mechanisms of barrier disruption after chronic alcohol feeding. A Lieber‐DeCarli model was used to induce intestinal dysbiosis, increased intestinal permeability, and liver disease in mice.

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

Paola Dongiovanni, Salvatore Petta, Cristina Maglio, Anna Ludovica Fracanzani, Rosaria Pipitone, Enrico Mozzi, Benedetta Maria Motta, Dorota Kaminska, Raffaela Rametta, Stefania Grimaudo, Serena Pelusi, Tiziana Montalcini, Anna Alisi, Marco Maggioni, Vesa Kärjä, Jan Borén, Pirjo Käkelä, Vito Di Marco, Chao Xing, Valerio Nobili, Bruno Dallapiccola, Antonio Craxi, Jussi Pihlajamäki, Silvia Fargion, Lars Sjöström, Lena M. Carlsson, Stefano Romeo, Luca Valenti – 24 September 2014

Cardiac dysfunction associated with a nucleotide polymerase inhibitor for treatment of hepatitis C

Tariq Ahmad, Philip Yin, Jeffrey Saffitz, Paul J. Pockros, Jacob Lalezari, Mitchell Shiffman, Bradley Freilich, Joann Zamparo, Kyle Brown, Dessislava Dimitrova, Monica Kumar, Doug Manion, Margo Heath‐Chiozzi, Robert Wolf, Eric Hughes, Andrew J. Muir, Adrian F. Hernandez – 24 September 2014 – Treatment for chronic hepatitis C virus (HCV) infection is evolving from interferon (IFN)‐based therapy to direct‐acting antiviral (DAA) agents, yet some safety concerns have arisen involving cardiac toxicity.

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

Paola Dongiovanni, Salvatore Petta, Cristina Maglio, Anna Ludovica Fracanzani, Rosaria Pipitone, Enrico Mozzi, Benedetta Maria Motta, Dorota Kaminska, Raffaela Rametta, Stefania Grimaudo, Serena Pelusi, Tiziana Montalcini, Anna Alisi, Marco Maggioni, Vesa Kärjä, Jan Borén, Pirjo Käkelä, Vito Di Marco, Chao Xing, Valerio Nobili, Bruno Dallapiccola, Antonio Craxi, Jussi Pihlajamäki, Silvia Fargion, Lars Sjöström, Lena M. Carlsson, Stefano Romeo, Luca Valenti – 24 September 2014

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

Paola Dongiovanni, Salvatore Petta, Cristina Maglio, Anna Ludovica Fracanzani, Rosaria Pipitone, Enrico Mozzi, Benedetta Maria Motta, Dorota Kaminska, Raffaela Rametta, Stefania Grimaudo, Serena Pelusi, Tiziana Montalcini, Anna Alisi, Marco Maggioni, Vesa Kärjä, Jan Borén, Pirjo Käkelä, Vito Di Marco, Chao Xing, Valerio Nobili, Bruno Dallapiccola, Antonio Craxi, Jussi Pihlajamäki, Silvia Fargion, Lars Sjöström, Lena M. Carlsson, Stefano Romeo, Luca Valenti – 24 September 2014

Double‐negative feedback loop between MicroRNA‐422a and forkhead box (FOX)G1/Q1/E1 regulates hepatocellular carcinoma tumor growth and metastasis

Jin Zhang, Yun Yang, Tian Yang, Shengxian Yuan, Ruoyu Wang, Zeya Pan, Yuan Yang, Gang Huang, Fangming Gu, Beige Jiang, Chuan Lin, Weiping Zhou – 24 September 2014 – Growing evidence indicates that the aberrant expression of microRNAs (miRNAs) contributes to tumor development; however, the function of miRNAs in human hepatocellular carcinoma (HCC) remains largely undefined.

Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation

Emilia Prakoso, Janina E. E. Tirnitz‐Parker, Andrew D. Clouston, Zeid Kayali, Aimei Lee, Eng K. Gan, Grant A. Ramm, James G. Kench, David G. Bowen, John K. Olynyk, Geoffrey W. McCaughan, Nicholas A. Shackel – 20 September 2014 – Fibrosis in livers with hepatitis C virus (HCV) recurrence after liver transplantation (LT) can be rapidly progressive, and the mechanisms underlying this process are poorly understood.

Intestinal ischemic preconditioning ameliorates hepatic ischemia/reperfusion injury in rats: Role of heme oxygenase 1 in the second window of protection

Shoichi Kageyama, Koichiro Hata, Hirokazu Tanaka, Hirofumi Hirao, Toyonari Kubota, Yusuke Okamura, Keiko Iwaisako, Yasutsugu Takada, Shinji Uemoto – 19 September 2014 – Preconditioning by brief ischemia protects not only the concerned organ but also other distant organs against subsequent lethal damage; this is called remote ischemic preconditioning (RIPC). This study was designed to investigate the impact of intestinal RIPC on hepatic ischemia/reperfusion injury (IRI) with a special interest in heme oxygenase 1 (HO‐1) induction in the second window of protection (SWOP).

First description of single‐pass albumin dialysis combined with cytokine adsorption in fulminant liver failure and hemophagocytic syndrome resulting from generalized herpes simplex virus 1 infection

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