Dynamic three‐dimensional morphogenesis of intrahepatic bile ducts in mouse liver development
Yasuo Takashima, Maiko Terada, Masuyo Kawabata, Atsushi Suzuki – 12 September 2014 – During liver development, biliary epithelial cells differentiated from bipotential hepatic progenitor cells (hepatoblasts) form a cell layer, called the ductal plate surrounding portal veins (PVs), and develop into intrahepatic bile ducts (IBDs) following developmental programs. Because IBDs make duct structures in the liver, it is necessary to perform sequential and three‐dimensional (3D) analyses from the early stages of liver development to address the process of morphogenesis in detail.