Dynamic three‐dimensional morphogenesis of intrahepatic bile ducts in mouse liver development

Yasuo Takashima, Maiko Terada, Masuyo Kawabata, Atsushi Suzuki – 12 September 2014 – During liver development, biliary epithelial cells differentiated from bipotential hepatic progenitor cells (hepatoblasts) form a cell layer, called the ductal plate surrounding portal veins (PVs), and develop into intrahepatic bile ducts (IBDs) following developmental programs. Because IBDs make duct structures in the liver, it is necessary to perform sequential and three‐dimensional (3D) analyses from the early stages of liver development to address the process of morphogenesis in detail.

Dynamic three‐dimensional morphogenesis of intrahepatic bile ducts in mouse liver development

Yasuo Takashima, Maiko Terada, Masuyo Kawabata, Atsushi Suzuki – 12 September 2014 – During liver development, biliary epithelial cells differentiated from bipotential hepatic progenitor cells (hepatoblasts) form a cell layer, called the ductal plate surrounding portal veins (PVs), and develop into intrahepatic bile ducts (IBDs) following developmental programs. Because IBDs make duct structures in the liver, it is necessary to perform sequential and three‐dimensional (3D) analyses from the early stages of liver development to address the process of morphogenesis in detail.

Clinical course of infection and viral tissue tropism of hepatitis C virus–like nonprimate hepaciviruses in horses

Stephanie Pfaender, Jessika M.V. Cavalleri, Stephanie Walter, Juliane Doerrbecker, Benedetta Campana, Richard J.P. Brown, Peter D. Burbelo, Alexander Postel, Kerstin Hahn, Anggakusuma, Nina Riebesehl, Wolfgang Baumgärtner, Paul Becher, Markus H. Heim, Thomas Pietschmann, Karsten Feige, Eike Steinmann – 12 September 2014 – Hepatitis C virus (HCV) has a very narrow species and tissue tropism and efficiently replicates only in humans and the chimpanzee. Recently, several studies identified close relatives to HCV in different animal species.

Portal hypertension and the outcome of surgery for hepatocellular carcinoma in compensated cirrhosis: A systematic review and meta‐analysis

Annalisa Berzigotti, Maria Reig, Juan G. Abraldes, Jaime Bosch, Jordi Bruix – 12 September 2014 – Whether preoperative clinically significant portal hypertension (CSPH) has or not an impact on the outcome of surgery for hepatocellular carcinoma (HCC) in patients with compensated cirrhosis is debated. This systematic review assesses the impact of CSPH on the outcome of HCC in patients with compensated cirrhosis treated with surgery.

Clinical course of infection and viral tissue tropism of hepatitis C virus–like nonprimate hepaciviruses in horses

Stephanie Pfaender, Jessika M.V. Cavalleri, Stephanie Walter, Juliane Doerrbecker, Benedetta Campana, Richard J.P. Brown, Peter D. Burbelo, Alexander Postel, Kerstin Hahn, Anggakusuma, Nina Riebesehl, Wolfgang Baumgärtner, Paul Becher, Markus H. Heim, Thomas Pietschmann, Karsten Feige, Eike Steinmann – 12 September 2014 – Hepatitis C virus (HCV) has a very narrow species and tissue tropism and efficiently replicates only in humans and the chimpanzee. Recently, several studies identified close relatives to HCV in different animal species.

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