Dysregulated serum response factor triggers formation of hepatocellular carcinoma

Stefan Ohrnberger, Abhishek Thavamani, Albert Braeuning, Daniel B. Lipka, Milen Kirilov, Robert Geffers, Stella E. Authenrieth, Michael Römer, Andreas Zell, Michael Bonin, Michael Schwarz, Günther Schütz, Peter Schirmacher, Christoph Plass, Thomas Longerich, Alfred Nordheim – 29 September 2014 – The ubiquitously expressed transcriptional regulator serum response factor (SRF) is controlled by both Ras/MAPK (mitogen‐activated protein kinase) and Rho/actin signaling pathways, which are frequently activated in hepatocellular carcinoma (HCC).

Differences in long‐term survival among liver transplant recipients and the general population: A population‐based nordic study

Fredrik Åberg, Mika Gissler, Tom H. Karlsen, Bo‐Göran Ericzon, Aksel Foss, Allan Rasmussen, William Bennet, Michael Olausson, Pål‐Dag Line, Arno Nordin, Annika Bergquist, Kirsten Muri Boberg, Maria Castedal, Christian Ross Pedersen, Helena Isoniemi – 29 September 2014 – Dramatic improvement in first‐year outcomes post‐liver transplantation (LT) has shifted attention to long‐term survival, where efforts are now needed to achieve improvement. Understanding the causes of premature death is a prerequisite for improving long‐term outcome.

Double‐negative feedback loop between MicroRNA‐422a and forkhead box (FOX)G1/Q1/E1 regulates hepatocellular carcinoma tumor growth and metastasis

Jin Zhang, Yun Yang, Tian Yang, Shengxian Yuan, Ruoyu Wang, Zeya Pan, Yuan Yang, Gang Huang, Fangming Gu, Beige Jiang, Chuan Lin, Weiping Zhou – 24 September 2014 – Growing evidence indicates that the aberrant expression of microRNAs (miRNAs) contributes to tumor development; however, the function of miRNAs in human hepatocellular carcinoma (HCC) remains largely undefined.

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