Perioperative changes in nutritional parameters and impact of graft size in patients undergoing adult living donor liver transplantation

Ahmed Hammad, Toshimi Kaido, Kohei Ogawa, Yasuhiro Fujimoto, Koji Tomiyama, Akira Mori, Tadahiro Uemura, Shinji Uemoto – 10 September 2014 – Derangements of various serum biochemical nutritional/metabolic parameters are common in patients with end‐stage liver disease who undergo liver transplantation (LT). The aim of this study was to explain the benefit of LT with respect to parameter changes and to examine the impact of the graft‐to‐recipient weight ratio (GRWR) on such changes.

A score model for the continuous grading of early allograft dysfunction severity

Eugenia Pareja, Miriam Cortes, David Hervás, José Mir, Andrés Valdivieso, José V. Castell, Agustín Lahoz – 10 September 2014 – Early allograft dysfunction (EAD) dramatically influences graft and patient outcomes. A lack of consensus on an EAD definition hinders comparisons of liver transplant outcomes and management of recipients among and within centers. We sought to develop a model for the quantitative assessment of early allograft function [Model for Early Allograft Function Scoring (MEAF)] after transplantation.

Connective tissue growth factor and integrin αvβ6: A new pair of regulators critical for ductular reaction and biliary fibrosis in mice

Liya Pi, Paulette M. Robinson, Marda Jorgensen, Seh‐Hoon Oh, Alicia R. Brown, Paul H. Weinreb, Thu Le Trinh, Protopapadakis Yianni, Chen Liu, Andrew Leask, Shelia M. Violette, Edward W. Scott, Gregory S. Schultz, Bryon E. Petersen – 9 September 2014 – Connective tissue growth factor (CTGF) is a matricellular protein that mediates cell‐matrix interaction through various subtypes of integrin receptors.

Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection

Mariko Esumi, Mariko Ishibashi, Hiromi Yamaguchi, Satomi Nakajima, Yuhi Tai, Sachiko Kikuta, Masahiko Sugitani, Tadatoshi Takayama, Maino Tahara, Makoto Takeda, Takaji Wakita – 9 September 2014 – The human liver reacts to hepatitis C virus (HCV) with a balanced response consisting of host anti‐ and proviral activities. To explore these subtle host responses, we used oligonucleotide microarrays to investigate the differential gene expression between two groups of liver samples with high and low HCV loads (>100‐fold difference).

Predictors of poor mental and physical health status among patients with chronic hepatitis C infection: The Chronic Hepatitis Cohort Study (CHeCS)

Joseph A. Boscarino, Mei Lu, Anne C. Moorman, Stuart C. Gordon, Loralee B. Rupp, Philip R. Spradling, Eyasu H. Teshale, Mark A. Schmidt, Vinutha Vijayadeva, Scott D. Holmberg, for the Chronic Hepatitis Cohort Study (CHeCS) Investigators – 9 September 2014 – Our objective was to assess the extent and risk factors for depression and poor physical health among patients with chronic hepatitis C virus (HCV) infection. We surveyed HCV‐infected patients seen at four large healthcare systems participating in the Chronic Hepatitis Cohort Study (CHeCS).

Effect of sofosbuvir and ribavirin treatment on peripheral and hepatic lipid metabolism in chronic hepatitis C virus, genotype 1–infected patients

Eric G. Meissner, Yu‐Jin Lee, Anu Osinusi, Zayani Sims, Jing Qin, Dan Sturdevant, John McHutchison, Mani Subramanian, Maureen Sampson, Susanna Naggie, Keyur Patel, Alan T. Remaley, Henry Masur, Shyam Kottilil – 9 September 2014 – Hepatitis C virus (HCV) modulates intrahepatic cholesterol biosynthetic pathways to promote viral replication. Chronic HCV infection is associated with altered metabolism, including dyslipidemia and insulin resistance (IR), which contributes to disease progression and influences response to therapy.

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