Irma Garcia‐Martinez, Wajahat Z. Mehal – 22 August 2014

Chunmei Wang, Antonio Cigliano, Lijie Jiang, Xiaolei Li, Biao Fan, Maria G. Pilo, Yan Liu, Bing Gui, Marcella Sini, Jeffrey W. Smith, Frank Dombrowski, Diego F. Calvisi, Matthias Evert, Xin Chen – 22 August 2014 – Concomitant expression of activated forms of v‐akt murine thymoma viral oncogene homolog (AKT) and Ras in mouse liver (AKT/Ras) leads to rapid tumor development through strong activation of the mammalian target of rapamycin complex 1 (mTORC1) pathway.

Fei He, Feng‐Cheng Guo, Zhi Li, Heng‐Chao Yu, Peng‐Fei Ma, Jun‐Long Zhao, Lei Feng, Wei‐Na Li, Xiao‐Wei Liu, Hong‐Yan Qin, Ke‐Feng Dou, Hua Han – 22 August 2014 – Macrophages play multidimensional roles in hepatic fibrosis, but their control has not been fully understood. The Notch pathway mediated by recombination signal binding protein Jκ (RBP‐J), the transcription factor transactivated by signals from four mammalian Notch receptors, is implicated in macrophage activation and plasticity.

Tamer Abdelrahman, Joseph Hughes, Janice Main, John McLauchlan, Mark Thursz, Emma Thomson – 22 August 2014

Maryann Maximos, Fernando Bril, Paola Portillo Sanchez, Romina Lomonaco, Beverly Orsak, Diane Biernacki, Amitabh Suman, Michelle Weber, Kenneth Cusi – 22 August 2014 – Plasma aminotransferases (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) are usually increased in patients with nonalcoholic fatty liver disease (NAFLD). However, the factors behind their elevation remain unclear.

Siyuan Ding, Michael D. Robek – 20 August 2014

Kang Kwang Lee, Naoki Imaizumi, Sally R. Chamberland, Nathan N. Alder, Urs A. Boelsterli – 20 August 2014 – Acetaminophen (APAP) overdose is a frequent cause of drug‐induced liver injury and the most frequent cause of acute liver failure in the Western world. Previous studies with mouse models have revealed that impairment of mitochondrial respiration is an early event in the pathogenesis, but the exact mechanisms have remained unclear, and therapeutic approaches to specifically target mitochondria have been insufficiently explored.

Basile Njei, Yaron Rotman, Ivo Ditah, Joseph K. Lim – 20 August 2014 – The rise in incidence of hepatocellular carcinoma (HCC) in the United States has been well documented. The purpose of this analysis was to examine temporal trends in HCC incidence, mortality, and survival within the U.S. population. The Surveillance, Epidemiology, and End Results data were used to examine incidence and incidence‐based (IB) mortality in HCC from 1973 to 2011. Secular trends in age‐adjusted incidence and IB mortality by sex and cancer stage were characterized using the Joinpoint Regression program.

Beom Kyung Kim, Hyon‐Suk Kim, Eun Jin Yoo, Eun Ji Oh, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang‐Hyub Han, Seung Up Kim, Young Nyun Park – 20 August 2014 – Serum fibrosis markers, such as the enhanced liver fibrosis (ELF) test, have been suggested as alternatives for liver biopsy (LB) in assessing liver fibrosis. We investigated the efficacy of the ELF test in predicting development of liver‐related events (LREs) in patients with chronic hepatitis B (CHB). A total of 170 patients (103 men; 60.6%) with CHB who underwent LB and serological tests for determining ELFs were enrolled.

Basile Njei, Yaron Rotman, Ivo Ditah, Joseph K. Lim – 20 August 2014 – The rise in incidence of hepatocellular carcinoma (HCC) in the United States has been well documented. The purpose of this analysis was to examine temporal trends in HCC incidence, mortality, and survival within the U.S. population. The Surveillance, Epidemiology, and End Results data were used to examine incidence and incidence‐based (IB) mortality in HCC from 1973 to 2011. Secular trends in age‐adjusted incidence and IB mortality by sex and cancer stage were characterized using the Joinpoint Regression program.