Kang Kwang Lee, Naoki Imaizumi, Sally R. Chamberland, Nathan N. Alder, Urs A. Boelsterli – 20 August 2014 – Acetaminophen (APAP) overdose is a frequent cause of drug‐induced liver injury and the most frequent cause of acute liver failure in the Western world. Previous studies with mouse models have revealed that impairment of mitochondrial respiration is an early event in the pathogenesis, but the exact mechanisms have remained unclear, and therapeutic approaches to specifically target mitochondria have been insufficiently explored.

Siyuan Ding, Michael D. Robek – 20 August 2014

Ajay Israni – 19 August 2014

Zhuolin Zou, Zhonghai Shen, Yijing Cai, Yi Chen, Si Chen, Yongping Chen – 19 August 2014

Laurie D. DeLeve – 18 August 2014 – Capillarization, lack of liver sinusoidal endothelial cell (LSEC) fenestration, and formation of an organized basement membrane not only precedes fibrosis, but is also permissive for hepatic stellate cell activation and fibrosis. Thus, dysregulation of the LSEC phenotype is a critical step in the fibrotic process. Both a vascular endothelial growth factor (VEGF)‐stimulated, nitric oxide (NO)‐independent pathway and a VEGF‐stimulated NO‐dependent pathway are necessary to maintain the differentiated LSEC phenotype.

Bastian Seubert, Barbara Grünwald, Julia Kobuch, Haissi Cui, Florian Schelter, Susanne Schaten, Jens T. Siveke, Ngee H. Lim, Hideaki Nagase, Nicole Simonavicius, Mathias Heikenwalder, Thomas Reinheckel, Jonathan P. Sleeman, Klaus‐Peter Janssen, Percy A. Knolle, Achim Krüger – 18 August 2014 – Due to its ability to inhibit prometastatic matrix metalloproteinases, tissue inhibitor of metalloproteinases (TIMP)‐1 has been thought to suppress tumor metastasis.

Raul Lazaro, Raymond Wu, Sunyoung Lee, Nian‐Ling Zhu, Chia‐Lin Chen, Samuel W. French, Jun Xu, Keigo Machida, Hidekazu Tsukamoto – 18 August 2014 – Alcoholic hepatitis (AH) is a distinct spectrum of alcoholic liver disease (ALD) with intense neutrophilic (polymorphonuclear; PMN) inflammation and high mortality. Although a recent study implicates osteopontin (SPP1) in AH, SPP1 is also shown to have protective effects on experimental ALD.

Guangqin Xiao, Jiayin Yang, Lunan Yan – 18 August 2014 – The aspartate aminotransferase‐to‐platelet ratio index (APRI) and fibrosis index based on the four factors (Fibrosis 4 index; FIB‐4) are the two most widely studied noninvasive tools for assessing liver fibrosis. Our aims were to systematically review the performance of APRI and FIB‐4 in hepatitis B virus (HBV) infection in adult patients and compare their advantages and disadvantages.

Aras N. Mattis, Guisheng Song, Kelly Hitchner, Roy Y. Kim, Andrew Y. Lee, Amar D. Sharma, Yann Malato, Michael T. McManus, Christine C. Esau, Erich Koller, Suneil Koliwad, Lee P. Lim, Jacquelyn J. Maher, Robert L. Raffai, Holger Willenbring – 18 August 2014

John W. Ward – 18 August 2014