Inflammatory cytokines promote the retrodifferentiation of tumor‐derived hepatocyte‐like cells to progenitor cells

Hélène Dubois‐Pot‐Schneider, Karim Fekir, Cédric Coulouarn, Denise Glaise, Caroline Aninat, Kathleen Jarnouen, Rémy Le Guével, Takashi Kubo, Seiichi Ishida, Fabrice Morel, Anne Corlu – 6 August 2014 – Human hepatocellular carcinoma (HCC) heterogeneity promotes recurrence and resistance to therapies. Recent studies have reported that HCC may be derived not only from adult hepatocytes and hepatoblasts but also hepatic stem/progenitors.

Molecular pathophysiology of portal hypertension

Mercedes Fernandez – 5 August 2014 – Over the past two decades the advances in molecular cell biology have led to significant discoveries about the pathophysiology of portal hypertension (PHT). In particular, great progress has been made in the study of the molecular and cellular mechanisms that regulate the increased intrahepatic vascular resistance (IHVR) in cirrhosis. We now know that the increased IHVR is not irreversible, but that both the structural component caused by fibrosis and the active component caused by hepatic sinusoidal constriction can be, at least partially, reversed.

Molecular pathophysiology of portal hypertension

Mercedes Fernandez – 5 August 2014 – Over the past two decades the advances in molecular cell biology have led to significant discoveries about the pathophysiology of portal hypertension (PHT). In particular, great progress has been made in the study of the molecular and cellular mechanisms that regulate the increased intrahepatic vascular resistance (IHVR) in cirrhosis. We now know that the increased IHVR is not irreversible, but that both the structural component caused by fibrosis and the active component caused by hepatic sinusoidal constriction can be, at least partially, reversed.

Inflammation‐based scores do not predict post‐transplant recurrence of hepatocellular carcinoma in patients within milan criteria

Ioanna Parisi, Emmanuel Tsochatzis, Hasitha Wijewantha, Manuel Rodríguez‐Perálvarez, Laura De Luca, Pinelopi Manousou, Evangelia Fatourou, Giulia Pieri, Vassilios Papastergiou, Neil Davies, Dominic Yu, TuVinh Luong, Amar Paul Dhillon, Douglas Thorburn, David Patch, James O'Beirne, Tim Meyer, Andrew K. Burroughs – 1 August 2014 – Increased preoperative inflammation scores, such as neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR) and inflammation‐based index (IBI) have been related to post‐transplant HCC recurrence.

Impact of quality as well as quantity of skeletal muscle on outcomes after liver transplantation

Yuhei Hamaguchi, Toshimi Kaido, Shinya Okumura, Yasuhiro Fujimoto, Kohei Ogawa, Akira Mori, Ahmed Hammad, Yumiko Tamai, Nobuya Inagaki, Shinji Uemoto – 1 August 2014 – Intramuscular fat accumulation has come to be associated with loss of muscle strength and function, one of the components of sarcopenia. However, the impact of preoperative quality of skeletal muscle on outcomes after living donor liver transplantation (LDLT) is unclear.

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