Plasma protein biomarkers enhance the clinical prediction of kidney injury recovery in patients undergoing liver transplantation

Josh Levitsky, Talia B. Baker, Chunfa Jie, Shubhada Ahya, Murray Levin, John Friedewald, Patrice Al‐Saden, Daniel R. Salomon, Michael M. Abecassis – 31 July 2014 – Biomarkers predictive of recovery from acute kidney injury (AKI) after liver transplantation (LT) could enhance decision algorithms regarding the need for liver‐kidney transplantation or renal sparing regimens. Multianalyte plasma/urine kidney injury protein panels were performed immediately before and 1 month post‐LT in an initial test group divided by reversible pre‐LT AKI (rAKI = post‐LT renal recovery) versus no AKI (nAKI).

Polymorphisms in melanoma differentiation‐associated gene 5 link protein function to clearance of hepatitis C virus

Franziska S. Hoffmann, Andreas Schmidt, Meike Dittmann Chevillotte, Christian Wisskirchen, Johannes Hellmuth, Simone Willms, Rachel H. Gilmore, Jürgen Glas, Matthias Folwaczny, Tobias Müller, Thomas Berg, Ulrich Spengler, Karen Fitzmaurice, Dermot Kelleher, Nicole Reisch, Charles M. Rice, Stefan Endres, Simon Rothenfusser – 30 July 2014

Conjugated bilirubin triggers anemia by inducing erythrocyte death

Elisabeth Lang, Sergios Gatidis, Noemi F. Freise, Hans Bock, Ralf Kubitz, Christian Lauermann, Hans Martin Orth, Caroline Klindt, Maximilian Schuier, Verena Keitel, Maria Reich, Guilai Liu, Sebastian Schmidt, Haifeng C. Xu, Syed M. Qadri, Diran Herebian, Aleksandra A. Pandyra, Ertan Mayatepek, Erich Gulbins, Florian Lang, Dieter Häussinger, Karl S. Lang, Michael Föller, Philipp A.

Global distribution and prevalence of hepatitis C virus genotypes

Jane P. Messina, Isla Humphreys, Abraham Flaxman, Anthony Brown, Graham S. Cooke, Oliver G. Pybus, Eleanor Barnes – 28 July 2014 – Hepatitis C virus (HCV) exhibits high genetic diversity, characterized by regional variations in genotype prevalence. This poses a challenge to the improved development of vaccines and pan‐genotypic treatments, which require the consideration of global trends in HCV genotype prevalence. Here we provide the first comprehensive survey of these trends.

Astrocyte elevated gene‐1 and c‐Myc cooperate to promote hepatocarcinogenesis in mice

Jyoti Srivastava, Ayesha Siddiq, Rachel Gredler, Xue‐Ning Shen, Devaraja Rajasekaran, Chadia L. Robertson, Mark A. Subler, Jolene J. Windle, Catherine I. Dumur, Nitai D. Mukhopadhyay, Dawn Garcia, Zhao Lai, Yidong Chen, Uthra Balaji, Paul B. Fisher, Devanand Sarkar – 28 July 2014 – Astrocyte elevated gene‐1 (AEG‐1) and c‐Myc are overexpressed in human hepatocellular carcinoma (HCC) functioning as oncogenes. AEG‐1 is transcriptionally regulated by c‐Myc, and AEG‐1 itself induces c‐Myc by activating the Wnt/β‐catenin–signaling pathway.

Liver regeneration after living donor transplantation: Adult‐to‐adult living donor liver transplantation cohort study

Kim M. Olthoff, Jean C. Emond, Tempie H. Shearon, Greg Everson, Talia B. Baker, Robert A. Fisher, Chris E. Freise, Brenda W. Gillespie, James E. Everhart – 28 July 2014 – Adult‐to‐adult living donors and recipients were studied to characterize patterns of liver growth and identify associated factors in a multicenter study. Three hundred and fifty donors and 353 recipients in the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study (A2ALL) receiving transplants between March 2003 and February 2010 were included.

Conjugated bilirubin triggers anemia by inducing erythrocyte death

Elisabeth Lang, Sergios Gatidis, Noemi F. Freise, Hans Bock, Ralf Kubitz, Christian Lauermann, Hans Martin Orth, Caroline Klindt, Maximilian Schuier, Verena Keitel, Maria Reich, Guilai Liu, Sebastian Schmidt, Haifeng C. Xu, Syed M. Qadri, Diran Herebian, Aleksandra A. Pandyra, Ertan Mayatepek, Erich Gulbins, Florian Lang, Dieter Häussinger, Karl S. Lang, Michael Föller, Philipp A.

Costs of telaprevir‐based triple therapy for hepatitis C: $189,000 per sustained virological response

Kian Bichoupan, Valerie Martel‐Laferriere, David Sachs, Michel Ng, Emily A. Schonfeld, Alexis Pappas, James Crismale, Alicia Stivala, Viktoriya Khaitova, Donald Gardenier, Michael Linderman, Ponni V. Perumalswami, Thomas D. Schiano, Joseph A. Odin, Lawrence Liu, Alan J. Moskowitz, Douglas T. Dieterich, Andrea D.

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