Effect of remote ischemic postconditioning on patients undergoing living donor liver transplantation

Won Ho Kim, Jong‐Hwan Lee, Justine Sangwook Ko, Jeong Jin Min, Mi Sook Gwak, Gaab Soo Kim, Suk Koo Lee – 21 July 2014 – The aim of this study was to evaluate the protective effect of remote ischemic postconditioning (RIPostC) on graft function and acute kidney injury (AKI) after living donor liver transplantation (LT). Recipients undergoing elective living donor LT were randomly assigned to either the RIPostC group or the control group. Immediately after reperfusion, 4 cycles of ischemia and reperfusion lasting for 5 minutes each were performed on 1 upper limb in the RIPostC group.

Posttranscriptional changes of serum albumin: Clinical and prognostic significance in hospitalized patients with cirrhosis

Marco Domenicali, Maurizio Baldassarre, Ferdinando A Giannone, Marina Naldi, Marianna Mastroroberto, Maurizio Biselli, Maristella Laggetta, Daniela Patrono, Carlo Bertucci, Mauro Bernardi, Paolo Caraceni – 21 July 2014 – Beside the regulation of fluid distribution, human serum albumin (HSA) carries other activities, such as binding, transport, and detoxification of many molecules. In patients with cirrhosis, HSA exhibits posttranscriptional alterations that likely affect its functions.

Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice

Min Yang, Daniel J. Antoine, James L. Weemhoff, Rosalind E. Jenkins, Anwar Farhood, B. Kevin Park, Hartmut Jaeschke – 21 July 2014 – Hepatic ischemia/reperfusion (IRP) injury is a significant clinical problem during tumor‐resection surgery (Pringle maneuver) and liver transplantation. However, the relative contribution of necrotic and apoptotic cell death to the overall liver injury is still controversial.

Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections

Barbara Rehermann, Antonio Bertoletti – 21 July 2014 – Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause a large proportion of acute and chronic liver disease worldwide. Over the past decades many immunological studies defined host immune responses that mediate spontaneous clearance of acute HBV and HCV infection. However, host immune responses are also relevant in the context of treatment‐induced clearance of chronic HBV and HCV infection.

Lysyl oxidase‐like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma

Carmen Chak‐Lui Wong, Aki Pui‐Wah Tse, Yan‐Ping Huang, Yan‐Ting Zhu, David Kung‐Chun Chiu, Robin Kit‐Ho Lai, Sandy Leung‐Kuen Au, Alan Ka‐Lun Kai, Joyce Man‐Fong Lee, Larry Lai Wei, Felice Ho‐Ching Tsang, Regina Cheuk‐Lam Lo, Jue Shi, Yong‐Ping Zheng, Chun‐Ming Wong, Irene Oi‐Lin Ng – 21 July 2014 – Poor prognosis of cancers, including hepatocellular carcinoma (HCC), is mainly associated with metastasis; however, the underlying mechanisms remain poorly understood. This article investigates the role of lysyl oxidase‐like 2 (LOXL‐2) in the biology of HCC metastasis.

When to perform hepatic resection for intermediate‐stage hepatocellular carcinoma

Alessandro Cucchetti, Benjamin Djulbegovic, Athanasios Tsalatsanis, Alessandro Vitale, Iztok Hozo, Fabio Piscaglia, Matteo Cescon, Giorgio Ercolani, Francesco Tuci, Umberto Cillo, Antonio Daniele Pinna – 21 July 2014 – Transcatheter arterial chemoembolization (TACE) is the first‐line therapy recommended for patients with intermediate hepatocellular carcinoma (HCC). However, in clinical practice, these patients are often referred to surgical teams to be evaluated for hepatectomy.

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