Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration

Jingling Jin, Il‐Hwa Hong, Kyle Lewis, Polina Iakova, Meghan Breaux, Yanjun Jiang, Emily Sullivan, Nicole Jawanmardi, Lubov Timchenko, Nikolai A. Timchenko – 9 July 2014 – Liver cancer is the fifth most common cancer. A highly invasive surgical resection of the liver tumor is the main approach used to eliminate the tumor. Mechanisms that terminate liver regeneration when the liver reaches the original size are not known.

Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration

Jingling Jin, Il‐Hwa Hong, Kyle Lewis, Polina Iakova, Meghan Breaux, Yanjun Jiang, Emily Sullivan, Nicole Jawanmardi, Lubov Timchenko, Nikolai A. Timchenko – 9 July 2014 – Liver cancer is the fifth most common cancer. A highly invasive surgical resection of the liver tumor is the main approach used to eliminate the tumor. Mechanisms that terminate liver regeneration when the liver reaches the original size are not known.

Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a

Thomas H.R. Carlsen, Jannie Pedersen, Jannick C. Prentoe, Erick Giang, Zhen‐Yong Keck, Lotte S. Mikkelsen, Mansun Law, Steven K.H. Foung, Jens Bukh – 8 July 2014 – Human monoclonal antibodies (HMAbs) with neutralizing capabilities constitute potential immune‐based treatments or prophylaxis against hepatitis C virus (HCV). However, lack of cell culture‐derived HCV (HCVcc) harboring authentic envelope proteins (E1/E2) has hindered neutralization investigations across genotypes, subtypes, and isolates.

Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver

Hendrik Vilstrup, Piero Amodio, Jasmohan Bajaj, Juan Cordoba, Peter Ferenci, Kevin D. Mullen, Karin Weissenborn, Philip Wong – 8 July 2014

Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver

Hendrik Vilstrup, Piero Amodio, Jasmohan Bajaj, Juan Cordoba, Peter Ferenci, Kevin D. Mullen, Karin Weissenborn, Philip Wong – 8 July 2014

Acute liver allograft antibody‐mediated rejection: An inter‐institutional study of significant histopathological features

Jacqueline G. O'Leary, S. Michelle Shiller, Christopher Bellamy, Michael A. Nalesnik, Hugo Kaneku, Linda W. Jennings, Kumiko Isse, Paul I. Terasaki, Göran B. Klintmalm, Anthony J. Demetris – 6 July 2014 – Acute antibody‐mediated rejection (AMR) occurs in a small minority of sensitized liver transplant recipients. Although histopathological characteristics have been described, specific features that could be used (1) to make a generalizable scoring system and (2) to trigger a more in‐depth analysis are needed to screen for this rare but important finding.

High early cardiovascular mortality after liver transplantation

Lisa B. VanWagner, Brittany Lapin, Josh Levitsky, John T. Wilkins, Michael M. Abecassis, Anton I. Skaro, Donald M. Lloyd‐Jones – 5 July 2014 – Cardiovascular disease (CVD) contributes to excessive long‐term mortality after liver transplantation (LT); however, little is known about early postoperative CVD mortality in the current era. In addition, there is no model for predicting early postoperative CVD mortality across centers.

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