Lysyl oxidase‐like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma
Carmen Chak‐Lui Wong, Aki Pui‐Wah Tse, Yan‐Ping Huang, Yan‐Ting Zhu, David Kung‐Chun Chiu, Robin Kit‐Ho Lai, Sandy Leung‐Kuen Au, Alan Ka‐Lun Kai, Joyce Man‐Fong Lee, Larry Lai Wei, Felice Ho‐Ching Tsang, Regina Cheuk‐Lam Lo, Jue Shi, Yong‐Ping Zheng, Chun‐Ming Wong, Irene Oi‐Lin Ng – 21 July 2014 – Poor prognosis of cancers, including hepatocellular carcinoma (HCC), is mainly associated with metastasis; however, the underlying mechanisms remain poorly understood. This article investigates the role of lysyl oxidase‐like 2 (LOXL‐2) in the biology of HCC metastasis.