When to perform hepatic resection for intermediate‐stage hepatocellular carcinoma

Alessandro Cucchetti, Benjamin Djulbegovic, Athanasios Tsalatsanis, Alessandro Vitale, Iztok Hozo, Fabio Piscaglia, Matteo Cescon, Giorgio Ercolani, Francesco Tuci, Umberto Cillo, Antonio Daniele Pinna – 21 July 2014 – Transcatheter arterial chemoembolization (TACE) is the first‐line therapy recommended for patients with intermediate hepatocellular carcinoma (HCC). However, in clinical practice, these patients are often referred to surgical teams to be evaluated for hepatectomy.

Lysyl oxidase‐like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma

Carmen Chak‐Lui Wong, Aki Pui‐Wah Tse, Yan‐Ping Huang, Yan‐Ting Zhu, David Kung‐Chun Chiu, Robin Kit‐Ho Lai, Sandy Leung‐Kuen Au, Alan Ka‐Lun Kai, Joyce Man‐Fong Lee, Larry Lai Wei, Felice Ho‐Ching Tsang, Regina Cheuk‐Lam Lo, Jue Shi, Yong‐Ping Zheng, Chun‐Ming Wong, Irene Oi‐Lin Ng – 21 July 2014 – Poor prognosis of cancers, including hepatocellular carcinoma (HCC), is mainly associated with metastasis; however, the underlying mechanisms remain poorly understood. This article investigates the role of lysyl oxidase‐like 2 (LOXL‐2) in the biology of HCC metastasis.

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