Hepatology highlights
Jean‐François Dufour – 22 July 2014
Hepatology highlights
Jean‐François Dufour – 22 July 2014
When to perform hepatic resection for intermediate‐stage hepatocellular carcinoma
Alessandro Cucchetti, Benjamin Djulbegovic, Athanasios Tsalatsanis, Alessandro Vitale, Iztok Hozo, Fabio Piscaglia, Matteo Cescon, Giorgio Ercolani, Francesco Tuci, Umberto Cillo, Antonio Daniele Pinna – 21 July 2014 – Transcatheter arterial chemoembolization (TACE) is the first‐line therapy recommended for patients with intermediate hepatocellular carcinoma (HCC). However, in clinical practice, these patients are often referred to surgical teams to be evaluated for hepatectomy.
New tool for the study of hepatitis C virus genotype 3 and its associated liver disease biology
Daniel J. Felmlee, Catherine Schuster, Thomas F. Baumert – 21 July 2014
Lysyl oxidase‐like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma
Carmen Chak‐Lui Wong, Aki Pui‐Wah Tse, Yan‐Ping Huang, Yan‐Ting Zhu, David Kung‐Chun Chiu, Robin Kit‐Ho Lai, Sandy Leung‐Kuen Au, Alan Ka‐Lun Kai, Joyce Man‐Fong Lee, Larry Lai Wei, Felice Ho‐Ching Tsang, Regina Cheuk‐Lam Lo, Jue Shi, Yong‐Ping Zheng, Chun‐Ming Wong, Irene Oi‐Lin Ng – 21 July 2014 – Poor prognosis of cancers, including hepatocellular carcinoma (HCC), is mainly associated with metastasis; however, the underlying mechanisms remain poorly understood. This article investigates the role of lysyl oxidase‐like 2 (LOXL‐2) in the biology of HCC metastasis.
Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections
Barbara Rehermann, Antonio Bertoletti – 21 July 2014 – Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause a large proportion of acute and chronic liver disease worldwide. Over the past decades many immunological studies defined host immune responses that mediate spontaneous clearance of acute HBV and HCV infection. However, host immune responses are also relevant in the context of treatment‐induced clearance of chronic HBV and HCV infection.
MicroRNAs in bile vesicles: Finding a trade‐off for biomarker discovery
Henk P. Roest, Cornelia J. Verhoeven, Luc J.W. van der Laan – 21 July 2014
Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice
Min Yang, Daniel J. Antoine, James L. Weemhoff, Rosalind E. Jenkins, Anwar Farhood, B. Kevin Park, Hartmut Jaeschke – 21 July 2014 – Hepatic ischemia/reperfusion (IRP) injury is a significant clinical problem during tumor‐resection surgery (Pringle maneuver) and liver transplantation. However, the relative contribution of necrotic and apoptotic cell death to the overall liver injury is still controversial.