Portal myofibroblasts promote vascular remodeling underlying cirrhosis formation through the release of microparticles

Sara Lemoinne, Axelle Cadoret, Pierre‐Emmanuel Rautou, Haquima El Mourabit, Vlad Ratziu, Christophe Corpechot, Colette Rey, Nelly Bosselut, Véronique Barbu, Dominique Wendum, Gérard Feldmann, Chantal Boulanger, Corneliu Henegar, Chantal Housset, Dominique Thabut – 12 July 2014 – Liver fibrosis expanding from portal tracts and vascular remodeling are determinant factors in the progression of liver diseases to cirrhosis. In the present study, we examined the potential contribution of portal myofibroblasts (PMFs) to the vascular changes leading to cirrhosis.

Liver injury from herbals and dietary supplements in the U.S. Drug‐Induced Liver Injury Network

Victor J. Navarro, Huiman Barnhart, Herbert L. Bonkovsky, Timothy Davern, Robert J. Fontana, Lafaine Grant, K. Rajender Reddy, Leonard B. Seeff, Jose Serrano, Averell H. Sherker, Andrew Stolz, Jayant Talwalkar, Maricruz Vega, Raj Vuppalanchi – 12 July 2014 – The Drug‐Induced Liver Injury Network (DILIN) studies hepatotoxicity caused by conventional medications as well as herbals and dietary supplements (HDS).

Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell‐like property of hepatocellular carcinoma cells by stabilizing NOP2

Fang Wang, Ji‐Hang Yuan, Shao‐Bing Wang, Fu Yang, Sheng‐Xian Yuan, Chen Ye, Ning Yang, Wei‐Ping Zhou, Wen‐Lin Li, Wen Li, Shu‐Han Sun – 12 July 2014 – Many protein‐coding oncofetal genes are highly expressed in murine and human fetal liver and silenced in adult liver. The protein products of these hepatic oncofetal genes have been used as clinical markers for the recurrence of hepatocellular carcinoma (HCC) and as therapeutic targets for HCC. Herein we examined the expression profiles of long noncoding RNAs (lncRNAs) found in fetal and adult liver in mice.

Phylogenetic clustering of hepatitis C virus among people who inject drugs in Vancouver, Canada

Brendan Jacka, Tanya Applegate, Mel Krajden, Andrea Olmstead, P. Richard Harrigan, Brandon D.L. Marshall, Kora DeBeck, M.‐J. Milloy, Francois Lamoury, Oliver G. Pybus, Viviane D. Lima, Gkikas Magiorkinis, Vincent Montoya, Julio Montaner, Jeffrey Joy, Conan Woods, Sabina Dobrer, Gregory J. Dore, Art F.Y. Poon, Jason Grebely – 12 July 2014

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