Lysyl oxidase‐like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma

Carmen Chak‐Lui Wong, Aki Pui‐Wah Tse, Yan‐Ping Huang, Yan‐Ting Zhu, David Kung‐Chun Chiu, Robin Kit‐Ho Lai, Sandy Leung‐Kuen Au, Alan Ka‐Lun Kai, Joyce Man‐Fong Lee, Larry Lai Wei, Felice Ho‐Ching Tsang, Regina Cheuk‐Lam Lo, Jue Shi, Yong‐Ping Zheng, Chun‐Ming Wong, Irene Oi‐Lin Ng – 21 July 2014 – Poor prognosis of cancers, including hepatocellular carcinoma (HCC), is mainly associated with metastasis; however, the underlying mechanisms remain poorly understood. This article investigates the role of lysyl oxidase‐like 2 (LOXL‐2) in the biology of HCC metastasis.

When to perform hepatic resection for intermediate‐stage hepatocellular carcinoma

Alessandro Cucchetti, Benjamin Djulbegovic, Athanasios Tsalatsanis, Alessandro Vitale, Iztok Hozo, Fabio Piscaglia, Matteo Cescon, Giorgio Ercolani, Francesco Tuci, Umberto Cillo, Antonio Daniele Pinna – 21 July 2014 – Transcatheter arterial chemoembolization (TACE) is the first‐line therapy recommended for patients with intermediate hepatocellular carcinoma (HCC). However, in clinical practice, these patients are often referred to surgical teams to be evaluated for hepatectomy.

Reciprocal activation between ATPase inhibitory factor 1 and NF‐κB drives hepatocellular carcinoma angiogenesis and metastasis

Ruipeng Song, Huiwen Song, Yingjian Liang, Dalong Yin, Heng Zhang, Tongsen Zheng, Jiabei Wang, Zhaoyang Lu, Xuan Song, Tiemin Pei, Youyou Qin, Yuejin Li, Changming Xie, Boshi Sun, Huawen Shi, Shuai Li, Xianzhi Meng, Guangchao Yang, Shangha Pan, Jiyuan Zhu, Shuyi Qi, Hongchi Jiang, Zhiyong Zhang, Lianxin Liu – 14 July 2014

Effect of social support and donation‐related concerns on ambivalence of living liver donor candidates

Yun‐Chieh Lai, Wei‐Chen Lee, Yeong‐Yuh Juang, Lee‐Lan Yen, Li‐Chueh Weng, Hsueh Fen Chou – 13 July 2014 – Ambivalence in the decision‐making process for living liver donors has the potential to result in their experiencing a negative mental status. To promote donor candidates' well‐being, it is important to study the factors related to ambivalence. Thus, the aim of this study was to explore the ambivalence of living liver donor candidates and to investigate the effect of social support and donation‐related concerns on their ambivalence. A cross‐sectional design was used.

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Konstantin Kazankov, Holger Jon Møller, Bo Martin Bibby, Hendrik Vilstrup, Jacob George, Henning Grønbæk – 12 July 2014

Liver injury from herbals and dietary supplements in the U.S. Drug‐Induced Liver Injury Network

Victor J. Navarro, Huiman Barnhart, Herbert L. Bonkovsky, Timothy Davern, Robert J. Fontana, Lafaine Grant, K. Rajender Reddy, Leonard B. Seeff, Jose Serrano, Averell H. Sherker, Andrew Stolz, Jayant Talwalkar, Maricruz Vega, Raj Vuppalanchi – 12 July 2014 – The Drug‐Induced Liver Injury Network (DILIN) studies hepatotoxicity caused by conventional medications as well as herbals and dietary supplements (HDS).

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