Hepatic inflammation and fibrosis: Functional links and key pathways

Ekihiro Seki, Robert F. Schwabe – 26 July 2014 – Inflammation is one of the most characteristic features of chronic liver disease of viral, alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease stages and associated with the development of fibrosis, cirrhosis, and hepatocellular carcinoma. In the past decade, numerous studies have contributed to improved understanding of the links between hepatic inflammation and fibrosis.

IL‐34 and macrophage colony‐stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells

Laurence Preisser, Charline Miot, Hélène Guillou‐Guillemette, Elodie Beaumont, Etienne D Foucher, Erwan Garo, Simon Blanchard, Isabelle Frémaux, Anne Croué, Isabelle Fouchard, Françoise Lunel‐Fabiani, Jérôme Boursier, Philippe Roingeard, Paul Calès, Yves Delneste, Pascale Jeannin – 26 July 2014 – Chronic hepatitis C virus (HCV) infection is characterized by progressive hepatic fibrosis, a process dependent on monocyte recruitment and accumulation into the liver.

Hepatic inflammation and fibrosis: Functional links and key pathways

Ekihiro Seki, Robert F. Schwabe – 26 July 2014 – Inflammation is one of the most characteristic features of chronic liver disease of viral, alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease stages and associated with the development of fibrosis, cirrhosis, and hepatocellular carcinoma. In the past decade, numerous studies have contributed to improved understanding of the links between hepatic inflammation and fibrosis.

Biliary complications in living donor right hepatectomy are affected by the method of bile duct division

Ahmad M. Sultan, Tarek Salah, Mohammed M. Elshobary, Omar M. Fathy, Ahmed N. Elghawalby, Amr M. Yassen, Mohammed A. Elmorshedy, Mohammed F. Elsadany, Usama A. Shiha, Mohamed Abdel Wahab – 25 July 2014 – The bile duct division is a crucial step in the donor hepatectomy. Multiple small ducts will make the biliary reconstruction more difficult and may influence the outcome of the recipient. Biliary leakage, bilomas and biliary strictures are well recognized donor complications that may be directly linked to bile duct division. Biliary division still needs more standardization.

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