Anne C. Moorman, Jian Xing, Stephen Ko, Loralee B. Rupp, Fujie Xu, Stuart C. Gordon, Mei Lu, Philip R. Spradling, Eyasu H. Teshale, Joseph A. Boscarino, Vinutha Vijayadeva, Mark A. Schmidt, Scott D. Holmberg, for the CHeCS Investigators – 13 August 2014 – To determine the stage of liver disease at initial diagnosis of hepatitis C virus (HCV) infection, we analyzed data from the Chronic Hepatitis Cohort Study (CHeCS), a large U.S. observational study.

Qian Xiao, Rashmi Sinha, Barry I. Graubard, Neal D. Freedman – 13 August 2014

Miriam Cortes, Niteen Tapuria, Shirin Elizabeth Khorsandi, Eugenia Pareja Ibars, Hector Vilca‐Melendez, Mohamed Rela, Nigel D. Heaton – 13 August 2014 – A diaphragmatic hernia (DH) is a rare complication of pediatric liver transplantation (LT), with multiple factors implicated in the pathophysiology. It is a potentially life‐threatening condition in the absence of early recognition and surgical treatment. A DH after LT has been reported in 16 patients in 7 case series. We report 10 cases from our institution and review the published literature to understand the underlying pathophysiology.

Christoph Wierling – 13 August 2014

Aldo J. Montano‐Loza – 11 August 2014

Jesper M. Kivelä – 11 August 2014

Silja Kosola, Mikko Pakarinen – 11 August 2014

Qilin Gu, Xiaojie Yang, Li Lin, Shaoyang Li, Qing Li, Shan Zhong, Jinrong Peng, Zongbin Cui – 8 August 2014 – Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder caused by abnormal lipid metabolisms, such as reduced hepatic fatty acid oxidation (FAO), but intracellular control of FAO under physio‐ and pathological conditions remains largely undefined. Here, we demonstrate that deprivation of Slc7a3a leads to hepatic steatosis in fasted zebrafish as a result of defects in arginine‐dependent nitric oxide (NO) synthesis.

Jiyoung Hwang, Young Kon Kim, Jong Man Kim, Won Jae Lee, Dongil Choi, Seong Sook Hong – 8 August 2014 – We sought to evaluate the diagnostic performance of gadoxetic acid–enhanced magnetic resonance imaging (MRI) with and without additional diffusion‐weighted imaging (DWI) in the detection of hepatocellular carcinoma (HCC) in pretransplant patients. We included 63 liver transplant patients (54 men and 9 women; mean age = 52 years) who had undergone gadoxetic acid–enhanced MRI with DWI at 3.0 T within 90 days before transplantation.

Rohit Loomba, Tanya Wolfson, Brandon Ang, Jonathan Hooker, Cynthia Behling, Michael Peterson, Mark Valasek, Grace Lin, David Brenner, Anthony Gamst, Richard Ehman, Claude Sirlin – 8 August 2014 – Retrospective studies have shown that two‐dimensional magnetic resonance elastography (2D‐MRE), a novel MR method for assessment of liver stiffness, correlates with advanced fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Prospective data on diagnostic accuracy of 2D‐MRE in the detection of advanced fibrosis in NAFLD are needed.