Fattyaciddesaturase 1 gene polymorphisms control human hepatic lipid composition

Libo Wang, Shaminie Athinarayanan, Guanglong Jiang, Naga Chalasani, Min Zhang, Wanqing Liu – 14 August 2014 – Fatty acid desaturase (FADS) genes and their variants have been associated with multiple metabolic phenotypes, including liver enzymes and hepatic fat accumulation, but the detailed mechanism remains unclear. We aimed to delineate the role of FADSs in modulating lipid composition in human liver. We performed a targeted lipidomic analysis of a variety of phospholipids, sphingolipids, and ceramides among 154 human liver tissue samples.

Late diagnosis of hepatitis C virus infection in the Chronic Hepatitis Cohort Study (CHeCS): Missed opportunities for intervention

Anne C. Moorman, Jian Xing, Stephen Ko, Loralee B. Rupp, Fujie Xu, Stuart C. Gordon, Mei Lu, Philip R. Spradling, Eyasu H. Teshale, Joseph A. Boscarino, Vinutha Vijayadeva, Mark A. Schmidt, Scott D. Holmberg, for the CHeCS Investigators – 13 August 2014 – To determine the stage of liver disease at initial diagnosis of hepatitis C virus (HCV) infection, we analyzed data from the Chronic Hepatitis Cohort Study (CHeCS), a large U.S. observational study.

Diaphragmatic hernia after liver transplantation in children: Case series and review of the literature

Miriam Cortes, Niteen Tapuria, Shirin Elizabeth Khorsandi, Eugenia Pareja Ibars, Hector Vilca‐Melendez, Mohamed Rela, Nigel D. Heaton – 13 August 2014 – A diaphragmatic hernia (DH) is a rare complication of pediatric liver transplantation (LT), with multiple factors implicated in the pathophysiology. It is a potentially life‐threatening condition in the absence of early recognition and surgical treatment. A DH after LT has been reported in 16 patients in 7 case series. We report 10 cases from our institution and review the published literature to understand the underlying pathophysiology.

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