Astrocyte elevated gene‐1 and c‐Myc cooperate to promote hepatocarcinogenesis in mice

Jyoti Srivastava, Ayesha Siddiq, Rachel Gredler, Xue‐Ning Shen, Devaraja Rajasekaran, Chadia L. Robertson, Mark A. Subler, Jolene J. Windle, Catherine I. Dumur, Nitai D. Mukhopadhyay, Dawn Garcia, Zhao Lai, Yidong Chen, Uthra Balaji, Paul B. Fisher, Devanand Sarkar – 28 July 2014 – Astrocyte elevated gene‐1 (AEG‐1) and c‐Myc are overexpressed in human hepatocellular carcinoma (HCC) functioning as oncogenes. AEG‐1 is transcriptionally regulated by c‐Myc, and AEG‐1 itself induces c‐Myc by activating the Wnt/β‐catenin–signaling pathway.

Liver regeneration after living donor transplantation: Adult‐to‐adult living donor liver transplantation cohort study

Kim M. Olthoff, Jean C. Emond, Tempie H. Shearon, Greg Everson, Talia B. Baker, Robert A. Fisher, Chris E. Freise, Brenda W. Gillespie, James E. Everhart – 28 July 2014 – Adult‐to‐adult living donors and recipients were studied to characterize patterns of liver growth and identify associated factors in a multicenter study. Three hundred and fifty donors and 353 recipients in the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study (A2ALL) receiving transplants between March 2003 and February 2010 were included.

Conjugated bilirubin triggers anemia by inducing erythrocyte death

Elisabeth Lang, Sergios Gatidis, Noemi F. Freise, Hans Bock, Ralf Kubitz, Christian Lauermann, Hans Martin Orth, Caroline Klindt, Maximilian Schuier, Verena Keitel, Maria Reich, Guilai Liu, Sebastian Schmidt, Haifeng C. Xu, Syed M. Qadri, Diran Herebian, Aleksandra A. Pandyra, Ertan Mayatepek, Erich Gulbins, Florian Lang, Dieter Häussinger, Karl S. Lang, Michael Föller, Philipp A.

Costs of telaprevir‐based triple therapy for hepatitis C: $189,000 per sustained virological response

Kian Bichoupan, Valerie Martel‐Laferriere, David Sachs, Michel Ng, Emily A. Schonfeld, Alexis Pappas, James Crismale, Alicia Stivala, Viktoriya Khaitova, Donald Gardenier, Michael Linderman, Ponni V. Perumalswami, Thomas D. Schiano, Joseph A. Odin, Lawrence Liu, Alan J. Moskowitz, Douglas T. Dieterich, Andrea D.

Global distribution and prevalence of hepatitis C virus genotypes

Jane P. Messina, Isla Humphreys, Abraham Flaxman, Anthony Brown, Graham S. Cooke, Oliver G. Pybus, Eleanor Barnes – 28 July 2014 – Hepatitis C virus (HCV) exhibits high genetic diversity, characterized by regional variations in genotype prevalence. This poses a challenge to the improved development of vaccines and pan‐genotypic treatments, which require the consideration of global trends in HCV genotype prevalence. Here we provide the first comprehensive survey of these trends.

Global distribution and prevalence of hepatitis C virus genotypes

Jane P. Messina, Isla Humphreys, Abraham Flaxman, Anthony Brown, Graham S. Cooke, Oliver G. Pybus, Eleanor Barnes – 28 July 2014 – Hepatitis C virus (HCV) exhibits high genetic diversity, characterized by regional variations in genotype prevalence. This poses a challenge to the improved development of vaccines and pan‐genotypic treatments, which require the consideration of global trends in HCV genotype prevalence. Here we provide the first comprehensive survey of these trends.

Acute liver failure after valproate exposure in patients with POLG1 mutations and the prognosis after liver transplantation

Johanna Hynynen, Tuomas Komulainen, Eija Tukiainen, Arno Nordin, Johanna Arola, Reetta Kälviäinen, Leena Jutila, Matias Röyttä, Reetta Hinttala, Kari Majamaa, Heikki Mäkisalo, Johanna Uusimaa – 28 July 2014 – Patients with mutations in the POLG1 gene encoding mitochondrial DNA polymerase gamma have an increased risk of valproate‐induced liver failure. POLG1 mutations are common, and these patients often suffer from intractable seizures. The role of liver transplantation in the treatment of patients with mitochondrial diseases has been controversial.

Subscribe to