Liver alkaline phosphatase: A missing link between choleresis and biliary inflammation

Raoul Poupon – 20 January 2015 – Several lines of evidence show that serum alkaline phosphatase (AP) is not only a signpost of cholestasis but also a surrogate marker of the severity of primary biliary cirrhosis and primary sclerosing cholangitis. In the present opinion article, we review and discuss the putative role of liver AP in health and in cholestatic diseases.

Treatment of hepatitis C in liver transplant patients: Interferon out, direct antiviral combos in

Jennifer C. Price, Norah A. Terrault – 20 January 2015 – Although chronic infection with hepatitis C virus (HCV) is the leading indication for liver transplantation in the United States, graft and patient survival rates are reduced because of HCV recurrence after transplant. Interferon‐based antiviral treatment administered either before or after transplant to prevent or treat HCV recurrence, respectively, is limited because of poor tolerability and low efficacy.

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