Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration

Jingling Jin, Il‐Hwa Hong, Kyle Lewis, Polina Iakova, Meghan Breaux, Yanjun Jiang, Emily Sullivan, Nicole Jawanmardi, Lubov Timchenko, Nikolai A. Timchenko – 9 July 2014 – Liver cancer is the fifth most common cancer. A highly invasive surgical resection of the liver tumor is the main approach used to eliminate the tumor. Mechanisms that terminate liver regeneration when the liver reaches the original size are not known.

Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration

Jingling Jin, Il‐Hwa Hong, Kyle Lewis, Polina Iakova, Meghan Breaux, Yanjun Jiang, Emily Sullivan, Nicole Jawanmardi, Lubov Timchenko, Nikolai A. Timchenko – 9 July 2014 – Liver cancer is the fifth most common cancer. A highly invasive surgical resection of the liver tumor is the main approach used to eliminate the tumor. Mechanisms that terminate liver regeneration when the liver reaches the original size are not known.

Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a

Thomas H.R. Carlsen, Jannie Pedersen, Jannick C. Prentoe, Erick Giang, Zhen‐Yong Keck, Lotte S. Mikkelsen, Mansun Law, Steven K.H. Foung, Jens Bukh – 8 July 2014 – Human monoclonal antibodies (HMAbs) with neutralizing capabilities constitute potential immune‐based treatments or prophylaxis against hepatitis C virus (HCV). However, lack of cell culture‐derived HCV (HCVcc) harboring authentic envelope proteins (E1/E2) has hindered neutralization investigations across genotypes, subtypes, and isolates.

Acute liver allograft antibody‐mediated rejection: An inter‐institutional study of significant histopathological features

Jacqueline G. O'Leary, S. Michelle Shiller, Christopher Bellamy, Michael A. Nalesnik, Hugo Kaneku, Linda W. Jennings, Kumiko Isse, Paul I. Terasaki, Göran B. Klintmalm, Anthony J. Demetris – 6 July 2014 – Acute antibody‐mediated rejection (AMR) occurs in a small minority of sensitized liver transplant recipients. Although histopathological characteristics have been described, specific features that could be used (1) to make a generalizable scoring system and (2) to trigger a more in‐depth analysis are needed to screen for this rare but important finding.

Ketanserin, a serotonin 2A receptor antagonist, alleviates ischemia‐related biliary fibrosis following donation after cardiac death liver transplantation in rats

Liping Chen, Geng Chen, Yibin Guo, Lei Liu, Li Xiao, Wenmei Fan, Bingyi Shi, Yeyong Qian – 5 July 2014 – Biliary fibrosis is a major complication after donation after cardiac death (DCD) liver transplantation. In this process, the roles of serotonin [5‐hydroxytryptamine (5‐HT)] and the 5‐HT2A receptor subtype are still unknown.

Acute and chronic postsurgical pain after living liver donation: Incidence and predictors

Susan Holtzman, Hance A. Clarke, Stuart A. McCluskey, Kara Turcotte, David Grant, Joel Katz – 5 July 2014 – Despite its prominence as a concern among potential surgical candidates, there is little information in the literature regarding the short‐ and long‐term pain experience after living liver donation. We undertook a prospective study to examine (1) the nature and incidence of acute and chronic pain after living donor hepatectomy and (2) the factors associated with an increased or decreased risk of adverse pain outcomes.

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