Karim J. Halazun, Rachel E. Patzer, Abbas A. Rana, Elizabeth C. Verna, Adam D. Griesemer, Ronald F. Parsons, Benjamin Samstein, James V. Guarrera, Tomoaki Kato, Robert S. Brown, Jean C. Emond – 20 June 2014
Arihiro Aihara, Chiung‐Kuei Huang, Mark J. Olsen, Qiushi Lin, Waihong Chung, Qi Tang, Xiaoqun Dong, Jack R. Wands – 20 June 2014 – Hepatocellular carcinoma (HCC) has a poor prognosis as a result of widespread intra‐ and extrahepatic metastases. There is an urgent need to understand signaling cascades that promote disease progression. Aspartyl‐(asparaginyl)‐β‐hydroxylase (ASPH) is a cell‐surface enzyme that generates enhanced cell motility, migration, invasion, and metastatic spread in HCC. We hypothesize that inhibition of its enzymatic activity could have antitumor effects.
Hiromi Abe, C. Nelson Hayes, Kazuaki Chayama – 18 June 2014
Paul J. Clark, Alexander J. Thompson, Keyur Patel, Andrew J. Muir, Michael L. Volk – 18 June 2014
Joao Seda Neto, Paulo Chapchap – 18 June 2014
Tom Darius, Raymond Reding – 18 June 2014
Francesca Rizzo, Adnan Hashim, Giovanna Marchese, Maria Ravo, Roberta Tarallo, Giovanni Nassa, Giorgio Giurato, Antonio Rinaldi, Angela Cordella, Marcello Persico, Pia Sulas, Andrea Perra, Giovanna M. Ledda‐Columbano, Amedeo Columbano, Alessandro Weisz – 16 June 2014 – Small noncoding RNAs comprise a growing family of molecules that regulate key cellular processes, including messenger RNA (mRNA) degradation, translational repression, and transcriptional gene silencing.
Fabian Geisler, Mario Strazzabosco – 16 June 2014 – This review critically discusses the most recent advances in the role of Notch signaling in liver development, homeostasis, and disease. It is now clear that the significance of Notch in determining mammalian cell fates and functions extends beyond development, and Notch is a major regular of organ homeostasis. Moreover, Notch signaling is reactivated upon injury and regulates the complex interactions between the distinct liver cell types involved in the repair process.
Fabian Geisler, Mario Strazzabosco – 16 June 2014 – This review critically discusses the most recent advances in the role of Notch signaling in liver development, homeostasis, and disease. It is now clear that the significance of Notch in determining mammalian cell fates and functions extends beyond development, and Notch is a major regular of organ homeostasis. Moreover, Notch signaling is reactivated upon injury and regulates the complex interactions between the distinct liver cell types involved in the repair process.
Marco Marzioni, Laura Agostinelli, Cinzia Candelaresi, Stefania Saccomanno, Samuele Minicis, Luca Maroni, Eleonora Mingarelli, Chiara Rychlicki, Luciano Trozzi, Jesus M. Banales, Antonio Benedetti, Gianluca Svegliati Baroni – 13 June 2014