Decline in hepatitis E virus antibody prevalence in southeastern Germany, 1996‐2011

Jürgen J. Wenzel, Mathias Sichler, Mathias Schemmerer, Gundula Behrens, Michael F. Leitzmann, Wolfgang Jilg – 9 June 2014 – In the past decade, an increasing frequency of acute hepatitis E was noted in Germany and other European countries. Moreover, a high prevalence (17%) of hepatitis E virus (HEV) immunoglobulin G antibodies (anti‐HEV) was recently found in the adult German population. Although this suggests an emerging pathogen, reports from other countries gave hints to a completely new aspect: a possible decrease in anti‐HEV prevalence during the last decades.

Decline in hepatitis E virus antibody prevalence in southeastern Germany, 1996‐2011

Jürgen J. Wenzel, Mathias Sichler, Mathias Schemmerer, Gundula Behrens, Michael F. Leitzmann, Wolfgang Jilg – 9 June 2014 – In the past decade, an increasing frequency of acute hepatitis E was noted in Germany and other European countries. Moreover, a high prevalence (17%) of hepatitis E virus (HEV) immunoglobulin G antibodies (anti‐HEV) was recently found in the adult German population. Although this suggests an emerging pathogen, reports from other countries gave hints to a completely new aspect: a possible decrease in anti‐HEV prevalence during the last decades.

Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex

Deshui Jia, Rui Dong, Ying Jing, Dan Xu, Qifeng Wang, Lei Chen, Qigen Li, Yuping Huang, Yuannv Zhang, Zhenfeng Zhang, Li Liu, Shan Zheng, Qiang Xia, Hongyang Wang, Kuiran Dong, Xianghuo He – 9 June 2014 – Hepatoblastoma (HB) is the most common primary liver tumor in children. Mutations in the β‐catenin gene that lead to constitutive activation of the Wnt pathway have been detected in a large proportion of HB tumors. To identify novel mutations in HB, we performed whole‐exome sequencing of six paired HB tumors and their corresponding lymphocytes.

Prevention of portal hypertension: From variceal development to clinical decompensation

Julio D. Vorobioff, Roberto J. Groszmann – 9 June 2014 – Pharmacological treatment of portal hypertension (PH) has been exclusively devoted to gastroesophageal varices–related events at different frameworks, including prophylactic, emergency, or preventive therapy. The goals of treatment are to avoid the first bleeding episode, stop active bleeding, and prevent bleeding recurrence, respectively. The objective of preprimary prophylaxis (PPP) is to avoid variceal development, and therefore it necessarily deals with patients with cirrhosis at earlier stages of the disease.

Prevention of portal hypertension: From variceal development to clinical decompensation

Julio D. Vorobioff, Roberto J. Groszmann – 9 June 2014 – Pharmacological treatment of portal hypertension (PH) has been exclusively devoted to gastroesophageal varices–related events at different frameworks, including prophylactic, emergency, or preventive therapy. The goals of treatment are to avoid the first bleeding episode, stop active bleeding, and prevent bleeding recurrence, respectively. The objective of preprimary prophylaxis (PPP) is to avoid variceal development, and therefore it necessarily deals with patients with cirrhosis at earlier stages of the disease.

Selection of a right posterior sector graft for living donor liver transplantation

Tomoharu Yoshizumi, Toru Ikegami, Koichi Kimura, Hideaki Uchiyama, Tetsuo Ikeda, Ken Shirabe, Yoshihiko Maehara – 3 June 2014 – Right posterior sector (RPS) grafts have been used to overcome graft size discrepancies, the major concern of living donor liver transplantation. Previous studies have reported the volumetry‐based selection of RPS grafts without anatomical exclusion. We reviewed our data and established selection criteria for RPS grafts. The procurement of RPS grafts [conventional (n = 3) and extended (n = 5)] was performed for 8 of 429 recipients at our center.

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