Hepatocytes buried in the cirrhotic livers of patients with biliary atresia proliferate and function in the livers of urokinase‐type plasminogen activator–NOG mice

Hiroshi Suemizu, Kazuaki Nakamura, Kenji Kawai, Yuichiro Higuchi, Mureo Kasahara, Junichiro Fujimoto, Akito Tanoue, Masato Nakamura – 18 May 2014 – The pathogenesis of biliary atresia (BA), which leads to end‐stage cirrhosis in most patients, has been thought to inflame and obstruct the intrahepatic and extrahepatic bile ducts. BA is not believed to be caused by abnormalities in parenchymal hepatocytes. However, there has been no report of a detailed analysis of hepatocytes buried in the cirrhotic livers of patients with BA.

Outcomes of patients with cytomegalovirus viremia at the time of liver transplantation

Jackrapong Bruminhent, Raymund R. Razonable – 17 May 2014 – Cytomegalovirus (CMV) infection has been associated with poor outcomes after liver transplantation. Whether it is safe to perform transplantation for patients with active CMV viremia is not known. Here we report the outcomes of 6 patients with CMV viremia immediately before or at the time of liver transplantation.

Three liver transplants after a single cadaveric procurement: Split liver transplantation plus domino liver transplantation, an infrequent but valid alternative for maximizing transplant sharing and applicability—report of the first Latin American case

Gabriel Gondolesi, Pablo Barros Schelotto, Esteban Halac, Pablo Romero, Marcelo Dip, Guillermo Cervio, Diego Ramisch, Francisco Klein, Silvia Niveyro, Guillermo Orce, Silvina Yantorno, Valeria Descalzi, Oscar Imventarza – 17 May 2014

HepG2 cells mount an effective antiviral interferon‐lambda based innate immune response to hepatitis C virus infection

Benjamin Israelow, Christopher M. Narbus, Marion Sourisseau, Matthew J. Evans – 16 May 2014 – Hepatitis C virus (HCV) exposure leads to persistent life‐long infections characterized by chronic inflammation often developing into cirrhosis and hepatocellular carcinoma. The mechanism by which HCV remains in the liver while inducing an inflammatory and antiviral response remains unclear.

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