Predictors of donor follow‐up after living donor liver transplantation

Robert S. Brown, Abigail R. Smith, Mary Amanda Dew, Brenda W. Gillespie, Peg Hill‐Callahan, Daniela P. Ladner – 13 May 2014 – Donor safety in living liver donation is of paramount importance; however, information on long‐term outcomes is limited by incomplete follow‐up. We sought to ascertain factors that predicted postdonation follow‐up in 456 living liver donors in the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study. Completed donor follow‐up was defined as physical, phone, or laboratory contact at a given time point.

Hepatic DNA deposition drives drug‐induced liver injury and inflammation in mice

Pedro Elias Marques, André Gustavo Oliveira, Rafaela Vaz Pereira, Bruna Araújo David, Lindisley Ferreira Gomides, Adriana Machado Saraiva, Daniele Araújo Pires, Júlia Tosta Novaes, Daniel O. Patricio, Daniel Cisalpino, Zélia Menezes‐Garcia, W. Matthew Leevy, Sarah Ellen Chapman, GermánArturo Mahecha, Rafael Elias Marques, Rodrigo Guabiraba, Vicente Paulo Martins, Danielle Gloria Souza, Daniel Santos Mansur, Mauro Martins Teixeira, M.

Risk factors and surgical management of anastomotic biliary complications after pediatric liver transplantation

Tom Darius, Jairo Rivera, Fabio Fusaro, Quirino Lai, Catherine de Magnée, Christophe Bourdeaux, Magdalena Janssen, Philippe Clapuyt, Raymond Reding – 9 May 2014 – Biliary complications (BCs) still remain the Achilles heel of liver transplantation (LT) with an overall incidence of 10% to 35% in pediatric series.

Cognitive impairment and electroencephalographic alterations before and after liver transplantation: What is reversible?

Francesca Campagna, Sara Montagnese, Sami Schiff, Anna Biancardi, Daniela Mapelli, Paolo Angeli, Carlo Poci, Umberto Cillo, Carlo Merkel, Angelo Gatta, Piero Amodio – 9 May 2014 – The influence of liver transplantation (LT) on mental performance is debated, as is the role of pretransplant overt hepatic encephalopathy (OHE). The aim of this study was to evaluate the time course of the neuropsychological and electroencephalogram (EEG) features of patients with cirrhosis before and after LT with respect to prior OHE.

Cylindromatosis gene CYLD regulates hepatocyte growth factor expression in hepatic stellate cells through interaction with histone deacetylase 7

Rajeswara R. Pannem, Christoph Dorn, Claus Hellerbrand, Ramin Massoumi – 9 May 2014 – Hepatic fibrosis is considered as a physiological wound‐healing response to liver injury. The process involves several factors, such as hepatocyte growth factor (HGF), which restrains hepatic injury and facilitates reversibility of fibrotic reaction in response to an acute insult. Chronic liver injury and sustained inflammation cause progressive fibrosis and, ultimately, organ dysfunction. The mechanisms tipping the balance from restoration to progressive liver tissue scarring are not well understood.

Sorafenib use in the transplant setting

Giulia Castelli, Patrizia Burra, Anna Giacomin, Alessandro Vitale, Marco Senzolo, Umberto Cillo, Fabio Farinati – 9 May 2014 – Liver transplantation (LT) is an established treatment for hepatocellular carcinoma (HCC), and sorafenib (SFN) is a validated treatment for patients harboring advanced tumors. It is still not clear whether the combination of the 2 treatments, with SFN used in the neoadjuvant, adjuvant, or recurrence setting, is useful and cost‐effective.

Sanguineous normothermic machine perfusion improves hemodynamics and biliary epithelial regeneration in donation after cardiac death porcine livers

Qiang Liu, Ahmed Nassar, Kevin Farias, Laura Buccini, William Baldwin, Martin Mangino, Ana Bennett, Colin O'Rourke, Toshiro Okamoto, Teresa Diago Uso, John Fung, Kareem Abu‐Elmagd, Charles Miller, Cristiano Quintini – 8 May 2014 – The effects of normothermic machine perfusion (NMP) on the postreperfusion hemodynamics and extrahepatic biliary duct histology of donation after cardiac death (DCD) livers after transplantation have not been addressed thoroughly and represent the objective of this study.

Impaired functional capacity in potential liver transplant candidates predicts short‐term mortality before transplantation

Maggie M. G. Ow, Paul Erasmus, Gary Minto, Richard Struthers, Moby Joseph, Aileen Smith, Usama M. Warshow, Matthew E. Cramp, Tim J. S. Cross – 8 May 2014 – Liver transplantation (LT) is a lifesaving treatment. Because of the shortage of donor organs, some patients will not survive long enough to receive a transplant. The identification of LT candidates at increased risk of short‐term mortality without transplantation may affect listing decisions.

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