Nikolien van de Ven, Joe Fortunak, Bryony Simmons, Nathan Ford, Graham S. Cooke, Saye Khoo, Andrew Hill – 6 December 2014 – Combinations of direct‐acting antivirals (DAAs) can cure hepatitis C virus (HCV) in the majority of treatment‐naïve patients. Mass treatment programs to cure HCV in developing countries are only feasible if the costs of treatment and laboratory diagnostics are very low. This analysis aimed to estimate minimum costs of DAA treatment and associated diagnostic monitoring.

Raymond D. Hickey, Shennen A. Mao, Bruce Amiot, Lukkana Suksanpaisan, Amber Miller, Rebecca Nace, Jaime Glorioso, Michael K. O'Connor, Kah Whye Peng, Yasuhiro Ikeda, Stephen J. Russell, Scott L. Nyberg – 6 December 2014 – Cell transplantation is a potential treatment for the many liver disorders that are currently only curable by organ transplantation. However, one of the major limitations of hepatocyte (HC) transplantation is an inability to monitor cells longitudinally after injection.

Zhen‐Yu Xiao, Babak Banan, Jianluo Jia, Pamela T. Manning, Ronald R. Hiebsch, Muthukumar Gunasekaran, Gundumi A. Upadhya, William A. Frazier, Thalachallour Mohanakumar, Yiing Lin, William C. Chapman – 6 December 2014 – Orthotopic liver transplantation (OLT) remains the standard treatment option for nonresponsive liver failure. Because ischemia/reperfusion injury (IRI) is an important impediment to the success of OLT, new therapeutic strategies are needed to reduce IRI.

Fiona O'Mahony, Kevin Wroblewski, Sheila M. O'Byrne, Hongfeng Jiang, Kara Clerkin, Jihane Benhammou, William S. Blaner, Simon W. Beaven – 6 December 2014 – Liver X receptors (LXRs) are determinants of hepatic stellate cell (HSC) activation and liver fibrosis. Freshly isolated HSCs from Lxrαβ−/− mice have increased lipid droplet (LD) size, but the functional consequences of this are unknown. Our aim was to determine whether LXRs link cholesterol to retinoid storage in HSCs and how this impacts activation.

Jian‐Gao Fan, Fu‐Sheng Wang – 5 December 2014

Jaswinder Singh Maras, Rakhi Maiwall, H.C. Harsha, Sukanta Das, Md.Shabir Hussain, Chandan Kumar, Chhagan Bihari, Archana Rastogi, Manoj Kumar, Nirupama Trehanpati, Shvetank Sharma, Akhilesh Pandey, Shiv Kumar Sarin – 5 December 2014 – Acute‐on‐chronic liver failure (ACLF) is an ailment with high incidence of multiorgan failure (MOF) and consequent mortality. Dysregulated iron homeostasis and macrophage dysfunction are linked to increased incidence of MOF.

Xingshun Qi, Xiaozhong Guo, Daiming Fan – 5 December 2014

Xiang‐Yong Li, Min‐Jun Bai, Lin‐Jun Chen, Jian‐Liang Xu, Zhi‐Huan Lin, Xing Li, Yan‐Fang Xing – 5 December 2014

Igor Maricic, Huiming Sheng, Idania Marrero, Ekihiro Seki, Tatiana Kisseleva, Som Chaturvedi, Natasha Molle, Stephanie A. Mathews, Bin Gao, Vipin Kumar – 5 December 2014 – Innate immune mechanisms leading to liver injury subsequent to chronic alcohol ingestion are poorly understood. Natural killer T (NKT) cells, enriched in the liver and comprised of at least two distinct subsets, type I and II, recognize different lipid antigens presented by CD1d molecules.

Chun‐Ju Chiang, Ya‐Wen Yang, Jin‐De Chen, San‐Lin You, Hwai‐I Yang, Mei‐Hsuan Lee, Mei‐Shu Lai, Chien‐Jen Chen – 5 December 2014 – A national viral hepatitis therapy program was launched in Taiwan in October 2003. This study aimed to assess the impact of the program on reduction of end‐stage liver disease (ESLD) burden. Profiles of national registries of households, cancers, and death certificates were used to derive incidence and mortality of ESLDs from 2000 to 2011.