HepG2 cells mount an effective antiviral interferon‐lambda based innate immune response to hepatitis C virus infection

Benjamin Israelow, Christopher M. Narbus, Marion Sourisseau, Matthew J. Evans – 16 May 2014 – Hepatitis C virus (HCV) exposure leads to persistent life‐long infections characterized by chronic inflammation often developing into cirrhosis and hepatocellular carcinoma. The mechanism by which HCV remains in the liver while inducing an inflammatory and antiviral response remains unclear.

MicroRNA‐331‐3p promotes proliferation and metastasis of hepatocellular carcinoma by targeting PH domain and leucine‐rich repeat protein phosphatase

Rui‐Min Chang, Hao Yang, Feng Fang, Jiang‐Feng Xu, Lian‐Yue Yang – 14 May 2014 – Hepatocellular carcinoma (HCC) is a highly invasive tumor with frequent intrahepatic or pulmonary metastasis, which is the main reason for high recurrence and poor survival of HCC after liver resection. However, the mechanisms for metastasis remain incompletely clear. Given that microRNAs (miRNAs) are implicated in HCC progression, we explored a potential role of miRNAs in metastasis by performing miRNA expression profiling in three subtypes of HCC with different metastatic potentials.

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