Shared decision making in transplantation: How patients see their role in the decision process of accepting a donor liver

Sanna op den Dries, Coby Annema, Aad P. van den Berg, Adelita V. Ranchor, Robert J. Porte – 24 May 2014 – At the time of the organ offer for transplantation, donor‐related risks such as disease transmission and graft failure are weighed against the patient's risk of remaining on the waiting list. The patient's commonly inactive role in decision making and the timing and extent of donor‐specific risk information have been discussed in the medical literature. This is the first study revealing the opinions of liver patients on these issues.

Time of hepatocellular carcinoma recurrence after liver resection and alpha‐fetoprotein Are important prognostic factors for salvage liver transplantation

Sanghoon Lee, Choon Hyuck David Kwon, Jong Man Kim, Jae‐Won Joh, Seung Woon Paik, Bong‐Wan Kim, Hee‐Jung Wang, Kwang‐Woong Lee, Kyung‐Suk Suh, Suk‐Koo Lee – 23 May 2014 – Salvage liver transplantation (LT) is considered a feasible option for the treatment of recurrent hepatocellular carcinoma (HCC). We performed this multicenter study to assess the risk factors associated with the recurrence of HCC and patient survival after salvage LT.

Treatment response in the PIVENS trial is associated with decreased hedgehog pathway activity

Cynthia D. Guy, Ayako Suzuki, Manal F. Abdelmalek, James L. Burchette, Anna Mae Diehl, for the NASH CRN – 22 May 2014 – Hedgehog (Hh) ligand production by ballooned hepatocytes drives nonalcoholic steatohepatitis (NASH) progression in mice. The NIDDK‐sponsored PIVENS trial (NCT00063622) showed that vitamin E (VitE) improved NASH. We investigated whether VitE treatment and improvement in NASH were associated with changes in Hh pathway activity.

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