Cholangiocarcinoma development: The resurgence of bile acids
Luca Maroni, Gianfranco Alpini, Marco Marzioni – 15 May 2014
Hepatitis B virus: The “metabolovirus” highjacks cholesterol and bile acid metabolism
Andreas Geier – 15 May 2014
Treating thrombosis in cirrhosis patients with new oral agents: Ready or not?
Nicolas M. Intagliata, Hillary Maitland, Patrick G. Northup, Stephen H. Caldwell – 15 May 2014
Valuing cure: Bridging cost‐effectiveness and coverage decisions for hepatitis C therapy
Mai T. Pho, Benjamin P. Linas – 14 May 2014
MicroRNA‐331‐3p promotes proliferation and metastasis of hepatocellular carcinoma by targeting PH domain and leucine‐rich repeat protein phosphatase
Rui‐Min Chang, Hao Yang, Feng Fang, Jiang‐Feng Xu, Lian‐Yue Yang – 14 May 2014 – Hepatocellular carcinoma (HCC) is a highly invasive tumor with frequent intrahepatic or pulmonary metastasis, which is the main reason for high recurrence and poor survival of HCC after liver resection. However, the mechanisms for metastasis remain incompletely clear. Given that microRNAs (miRNAs) are implicated in HCC progression, we explored a potential role of miRNAs in metastasis by performing miRNA expression profiling in three subtypes of HCC with different metastatic potentials.
Hepatic DNA deposition drives drug‐induced liver injury and inflammation in mice
Pedro Elias Marques, André Gustavo Oliveira, Rafaela Vaz Pereira, Bruna Araújo David, Lindisley Ferreira Gomides, Adriana Machado Saraiva, Daniele Araújo Pires, Júlia Tosta Novaes, Daniel O. Patricio, Daniel Cisalpino, Zélia Menezes‐Garcia, W. Matthew Leevy, Sarah Ellen Chapman, GermánArturo Mahecha, Rafael Elias Marques, Rodrigo Guabiraba, Vicente Paulo Martins, Danielle Gloria Souza, Daniel Santos Mansur, Mauro Martins Teixeira, M.
Predictors of donor follow‐up after living donor liver transplantation
Robert S. Brown, Abigail R. Smith, Mary Amanda Dew, Brenda W. Gillespie, Peg Hill‐Callahan, Daniela P. Ladner – 13 May 2014 – Donor safety in living liver donation is of paramount importance; however, information on long‐term outcomes is limited by incomplete follow‐up. We sought to ascertain factors that predicted postdonation follow‐up in 456 living liver donors in the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study. Completed donor follow‐up was defined as physical, phone, or laboratory contact at a given time point.
Prometheus unbound: NKT cells inhibit hepatic regeneration
William M. Ridgway, M. Eric Gershwin – 13 May 2014
Retinoblastoma protein potentiates the innate immune response in hepatocytes: Significance for hepatocellular carcinoma
Jack Hutcheson, Ryan J. Bourgo, Uthra Balaji, Adam Ertel, Agnieszka K. Witkiewicz, Erik S. Knudsen – 13 May 2014 – Cancers mediated by viral etiology must exhibit deregulated cellular proliferation and evade immune recognition. The role of the retinoblastoma tumor suppressor (RB) pathway, which is lost at relatively high frequency in hepatocellular carcinoma (HCC), has recently been expanded to include the regulation of innate immune responsiveness. In this study we investigated the coordinate impact of RB‐loss on cell cycle control and immune function in the liver.
Overexpression of far upstream element (FUSE) binding protein (FBP)‐interacting repressor (FIR) supports growth of hepatocellular carcinoma
Mona Malz, Michael Bovet, Jana Samarin, Uta Rabenhorst, Carsten Sticht, Michaela Bissinger, Stephanie Roessler, Justo Lorenzo Bermejo, Marcus Renner, Diego Francesco Calvisi, Stephan Singer, Matthias Ganzinger, Achim Weber, Norbert Gretz, Martin Zörnig, Peter Schirmacher, Kai Breuhahn – 13 May 2014 – The far upstream element binding protein (FBP) and the FBP‐interacting repressor (FIR) represent molecular tools for transcriptional fine tuning of target genes.