Sung‐Min Ahn, Se Jin Jang, Ju Hyun Shim, Deokhoon Kim, Seung‐Mo Hong, Chang Ohk Sung, Daehyun Baek, Farhan Haq, Adnan Ahmad Ansari, Sun Young Lee, Sung‐Min Chun, Seongmin Choi, Hyun‐Jeung Choi, Jongkyu Kim, Sukjun Kim, Shin Hwang, Young‐Joo Lee, Jong‐eun Lee, Wang‐rim Jung, Hye Yoon Jang, Eunho Yang, Wing‐Kin Sung, Nikki P.
Michael H. Levy, Sarah Larney – 3 May 2014
Koen Vercauteren, Naomi Van Den Eede, Ahmed Atef Mesalam, Sandrine Belouzard, Maria Teresa Catanese, Dorothea Bankwitz, Flossie Wong‐Staal, Riccardo Cortese, Jean Dubuisson, Charles M. Rice, Thomas Pietschmann, Geert Leroux‐Roels, Alfredo Nicosia, Philip Meuleman – 3 May 2014 – Hepatitis C virus (HCV)‐induced endstage liver disease is currently a major indication for liver transplantation. After transplantation the donor liver inevitably becomes infected with the circulating virus.
Changchun Cai, Hai Huang, Sean Whelan, Li Liu, Benjamin Kautza, Jason Luciano, Guoliang Wang, Guoqiang Chen, Sladjana Stratimirovic, Allan Tsung, Timothy R. Billiar, Brian S. Zuckerbraun – 3 May 2014 – Acetaminophen (APAP) toxicity is the most common cause of acute liver failure in industrialized countries. Understanding the mechanisms of APAP‐induced liver injury as well as other forms of sterile liver injury is critical to improve the care of patients. Recent studies demonstrate that danger signaling and inflammasome activation play a role in APAP‐induced injury.
Sulyi Kim, Tomoko Date, Hiroshi Yokokawa, Tamaki Kono, Hideki Aizaki, Patrick Maurel, Claire Gondeau, Takaji Wakita – 3 May 2014 – Hepatitis C virus (HCV) genotype 3a infection poses a serious health problem worldwide. A significant association has been reported between HCV genotype 3a infections and hepatic steatosis. Nevertheless, virological characterization of genotype 3a HCV is delayed due to the lack of appropriate virus cell culture systems. In the present study, we established the first infectious genotype 3a HCV system by introducing adaptive mutations into the S310 strain.
Sonya Parpart, Stephanie Roessler, Fei Dong, Vinay Rao, Atsushi Takai, Junfang Ji, Lun‐Xiu Qin, Qing‐Hai Ye, Hu‐Liang Jia, Zhao‐You Tang, Xin Wei Wang – 3 May 2014 – Globally, hepatocellular carcinoma (HCC) accounts for 70%‐85% of primary liver cancers and ranks as the second leading cause of male cancer death. Serum alpha‐fetoprotein (AFP), normally highly expressed in the liver only during fetal development, is reactivated in 60% of HCC tumors and associated with poor patient outcome. We hypothesize that AFP+ and AFP− tumors differ biologically.
Marine Baptissart, Aurélie Vega, Emmanuelle Martinot, Aurélien J. Pommier, Sander M. Houten, Geoffroy Marceau, Angélique de Haze, Silvère Baron, Kristina Schoonjans, Jean‐Marc A. Lobaccaro, David H. Volle – 3 May 2014 – Bile acids (BAs) are signaling molecules that are involved in many physiological functions, such as glucose and energy metabolism. These effects are mediated through activation of the nuclear and membrane receptors, farnesoid X receptor (FXR‐α) and TGR5 (G‐protein‐coupled bile acid receptor 1; GPBAR1).
Natasha K. Martin, Peter Vickerman, David Goldberg, Matthew Hickman – 3 May 2014
Xiaodan Zhang, William S. Harmsen, Teresa A. Mettler, W. Ray Kim, Rosebud O. Roberts, Terry M. Therneau, Lewis R. Roberts, Roongruedee Chaiteerakij – 3 May 2014 – The risks and benefits of metformin use in patients with cirrhosis with diabetes are debated. Although data on a protective effect of metformin against liver cancer development have been reported, metformin is frequently discontinued once cirrhosis is diagnosed because of concerns about an increased risk of adverse effects of metformin in patients with liver impairment.
Tamer Abdelrahman, Joseph Hughes, Janice Main, John McLauchlan, Mark Thursz, Emma Thomson – 2 May 2014 – High rates of sexually transmitted infection and reinfection with hepatitis C virus (HCV) have recently been reported in human immunodeficiency virus (HIV)‐infected men who have sex with men and reinfection has also been described in monoinfected injecting drug users. The diagnosis of reinfection has traditionally been based on direct Sanger sequencing of samples pre‐ and posttreatment, but not on more sensitive deep sequencing techniques.