Xiaodan Zhang, William S. Harmsen, Teresa A. Mettler, W. Ray Kim, Rosebud O. Roberts, Terry M. Therneau, Lewis R. Roberts, Roongruedee Chaiteerakij – 3 May 2014 – The risks and benefits of metformin use in patients with cirrhosis with diabetes are debated. Although data on a protective effect of metformin against liver cancer development have been reported, metformin is frequently discontinued once cirrhosis is diagnosed because of concerns about an increased risk of adverse effects of metformin in patients with liver impairment.

Tamer Abdelrahman, Joseph Hughes, Janice Main, John McLauchlan, Mark Thursz, Emma Thomson – 2 May 2014 – High rates of sexually transmitted infection and reinfection with hepatitis C virus (HCV) have recently been reported in human immunodeficiency virus (HIV)‐infected men who have sex with men and reinfection has also been described in monoinfected injecting drug users. The diagnosis of reinfection has traditionally been based on direct Sanger sequencing of samples pre‐ and posttreatment, but not on more sensitive deep sequencing techniques.

Gwen Murphy, Angelika Michel, Philip R. Taylor, Demetrius Albanes, Stephanie J. Weinstein, Jarmo Virtamo, Dominick Parisi, Kirk Snyder, Julia Butt, Katherine A. McGlynn, Jill Koshiol, Michael Pawlita, Gabriel Y. Lai, Christian C. Abnet, Sanford M. Dawsey, Neal D. Freedman – 2 May 2014 – Helicobacter have been detected in human bile and hepatobiliary tissue. Despite evidence that Helicobacter species promote gallstone formation and hepatobiliary tumors in laboratory studies, it remains unclear whether Helicobacter species contribute to these cancers in humans.

Arikichenin Olithselvan, Srinivas Rajagopala, Mukul Vij, Vivekanandan Shanmugam, Naresh Shanmugam, Mohammed Rela – 30 April 2014 – Tuberculosis (TB) is a serious disease for liver transplant recipients (LTRs). Data on post–liver transplant TB from high‐burden countries are scant. The aims of this study were to describe the prevalence of TB in LTRs from a high‐prevalence area and to analyze the risk factors for the development of post–liver transplant TB. We performed a retrospective review of our database and a case‐control study of identified cases with TB and age‐matched LTRs without TB.

Yaojen Chang, Lorenzo Gallon, Colleen Jay, Kirti Shetty, Bing Ho, Josh Levitsky, Talia Baker, Daniela Ladner, John Friedewald, Michael Abecassis, Gordon Hazen, Anton I. Skaro – 29 April 2014 – There are complex risk‐benefit tradeoffs with different transplantation strategies for end‐stage liver disease patients on renal support.

Mattia Garancini, Paolo Goffredo, Fabio Pagni, Fabrizio Romano, Sanziana Roman, Julie Ann Sosa, Vittorio Giardini – 29 April 2014 – Combined hepatocellular‐cholangiocarcinoma (cHCC‐CC) is a rare primary liver cancer. Our aims were to analyze the demographic, clinical, and pathological characteristics of cHCC‐CC at a population level and to investigate the effects of these features as well as different management strategies on the prognosis. The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for 1988‐2009.

M. Thamara P. R. Perera, Tom Clutton‐Brock, Paolo Muiesan – 29 April 2014

Robert H. Squires, Vicky Ng, Rene Romero, Udeme Ekong, Winita Hardikar, Sukru Emre, George V. Mazariegos – 29 April 2014

Cornelia J. Verhoeven, Herold J. Metselaar, Luc J. W. Laan – 29 April 2014

Denise M. Harnois, Maria L. Yataco, Raouf E. Nakhleh – 28 April 2014 – Watch a video presentation of this article