Incorporation of primary patient‐derived glycoproteins into authentic infectious hepatitis C virus particles

Juliane Doerrbecker, Martina Friesland, Nina Riebesehl, Corinne Ginkel, Patrick Behrendt, Richard J.P. Brown, Sandra Ciesek, Heiner Wedemeyer, Christoph Sarrazin, Lars Kaderali, Thomas Pietschmann, Eike Steinmann – 27 April 2014 – The Japanese fulminant hepatitis‐1 (JFH1)‐based hepatitis C virus (HCV) infection system has permitted analysis of the complete viral replication cycle in vitro. However, lack of robust infection systems for primary, patient‐derived isolates limits systematic functional studies of viral intrahost variation and vaccine development.

IL‐20 and IL‐20R1 antibodies protect against liver fibrosis

Yi‐Shu Chiu, Chi‐Chen Wei, Yih‐Jyh Lin, Yu‐Hsiang Hsu, Ming‐Shi Chang – 25 April 2014 – Interleukin (IL)‐20 is a proinflammatory cytokine of the IL‐10 family and involved in rheumatoid arthritis, atherosclerosis, stroke, and osteoporosis. However, the pathophysiological roles of IL‐20 in liver injury have not been extensively studied. We explored the involvement of IL‐20 in liver injury and the therapeutic potential of IL‐20 antagonists for treating liver fibrosis.

Human OX40 tunes the function of regulatory T cells in tumor and nontumor areas of hepatitis C virus–infected liver tissue

Silvia Piconese, Eleonora Timperi, Ilenia Pacella, Valeria Schinzari, Claudio Tripodo, Massimo Rossi, Nicola Guglielmo, Gianluca Mennini, Gian Luca Grazi, Simona Di Filippo, Stefania Brozzetti, Katia Fazzi, Guido Antonelli, Maria Antonietta Lozzi, Massimo Sanchez, Vincenzo Barnaba – 23 April 2014 – Regulatory T cells (Tregs) can be considered as a mixed population of distinct subsets, endowed with a diverse extent and quality of adaptation to microenvironmental signals.

Diagnosis and management of biliary complications in pediatric living donor liver transplant recipients

Flávia H. Feier, Paulo Chapchap, Renata Pugliese, Eduardo A. Fonseca, Francisco C. Carnevale, Airton M. Moreira, Charles Zurstrassen, Aline C. Santos, Irene K. Miura, Vera Baggio, Adriana Porta, Teresa Guimarães, Helry Cândido, Marcel Benavides, Andre Godoy, Katia M. R. Leite, Gilda Porta, Mario Kondo, João Seda‐Neto – 23 April 2014 – The incidence of biliary complications (BCs) after living donor liver transplantation (LDLT) can reach 40%. Published data on the pediatric population are limited, and treatment protocols vary.

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