Surgical site infections after liver retransplantation: Incidence and risk factors

Harshal Shah, Walter C. Hellinger, Michael G. Heckman, Nancy Diehl, Jefree A. Shalev, Darrin L. Willingham, C. Burcin Taner, Dana K. Perry, Justin Nguyen – 18 April 2014 – Surgical site infections (SSIs) after liver transplantation (LT) are associated with an increased risk of graft loss and death. The incidence of SSIs after LT and their risk factors have been determined for first LT but not for second LT. The importance of reporting the incidence of SSIs risk‐stratified by first LT versus second LT is not known.

Pilot study of high‐intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients wait‐listed for liver transplantation

Kenneth S. H. Chok, Tan To Cheung, Regina C. L. Lo, Ferdinand S. K. Chu, Simon H. Y. Tsang, Albert C. Y. Chan, William W. Sharr, James Y. Y. Fung, Wing Chiu Dai, See Ching Chan, Sheung Tat Fan, Chung Mau Lo – 18 April 2014 – The objective of this study was to investigate the outcomes of high‐intensity focused ultrasound (HIFU) ablation as a bridging therapy for patients with hepatocellular carcinoma (HCC) who had been wait‐listed for deceased donor liver transplantation (DDLT).

Long‐term effect of childhood liver transplantation on body cell mass

Looi Cheng Ee, Rebecca Joanne Hill, Kerrie Beale, Charlton Noble, Jonathan Fawcett, Geoffrey John Cleghorn – 18 April 2014 – Malnutrition is common in end‐stage liver disease, but a correction after transplantation is expected. Body cell mass (BCM) assessment using total body potassium (TBK) measurements is considered the gold standard for assessing nutritional status. The aim of this study was to examine the BCM and, therefore, nutritional status of long‐term survivors after childhood liver transplantation.

Transcriptional dynamics of bile salt export pump during pregnancy: Mechanisms and implications in intrahepatic cholestasis of pregnancy

Xiulong Song, Alexander Vasilenko, Yuan Chen, Leila Valanejad, Ruchi Verma, Bingfang Yan, Ruitang Deng – 11 April 2014 – Bile salt export pump (BSEP) is responsible for biliary secretion of bile acids, a rate‐limiting step in the enterohepatic circulation of bile acids and transactivated by nuclear receptor farnesoid X receptor (FXR). Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent disorder among diseases unique to pregnancy and primarily occurs in the third trimester of pregnancy, with a hallmark of elevated serum bile acids.

Phosphorylation of ABCB4 impacts its function: Insights from disease‐causing mutations

Julien Gautherot, Danièle Delautier, Marie‐Anne Maubert, Tounsia Aït‐Slimane, Gérard Bolbach, Jean‐Louis Delaunay, Anne‐Marie Durand‐Schneider, Delphine Firrincieli, Véronique Barbu, Nicolas Chignard, Chantal Housset, Michèle Maurice, Thomas Falguières – 10 April 2014 – The ABCB4 transporter mediates phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defects cause biliary diseases.

Helicobacter pylori might contribute to nonalcoholic fatty liver disease–related cardiovascular events by releasing prothrombotic and proinflammatory factors

Jannis Kountouras, Stergios A. Polyzos, Christos Zavos, Georgia Deretzi, Constantinos Kountouras, Elizabeth Vardaka, Panagiotis Katsinelos, Elena Tsiaousi, Nikolaos Grigoriadis, Iordanis Romiopoulos, Dimitrios Tzilves, Evangelia Giartza‐Taxidou – 10 April 2014

Thymic stromal lymphopoietin and interleukin‐4 mediate the pathogenesis of halothane‐induced liver injury in mice

William R. Proctor, Mala Chakraborty, Aaron M. Fullerton, Midhun C. Korrapati, Pauline M. Ryan, Kenrick Semple, Jeffrey C. Morrison, Julia D. Berkson, Lynette S. Chea, Qian Yang, Albert P. Li, Rosanne Spolski, Erin E. West, Yrina Rochman, Warren J. Leonard, Mohammed Bourdi, Lance R. Pohl – 10 April 2014 – Liver eosinophilia has been associated with incidences of drug‐induced liver injury (DILI) for more than 50 years, although its role in this disease has remained largely unknown.

Etiology and mortality of spontaneous bacterial peritonitis in liver transplant recipients: A cohort study

Cristina Pérez‐Cameo, Víctor Vargas, Lluís Castells, Itxarone Bilbao, Isabel Campos‐Varela, Joan Gavaldà, Albert Pahissa, Oscar Len – 10 April 2014 – Spontaneous bacterial peritonitis (SBP) in liver transplantation (LT) recipients who progress to cirrhosis has received little attention. We investigated the adequacy of empirical treatment with third‐generation cephalosporins for SBP in this population and the impact of transplantation on the evolution of the infection. We performed a cohort study with 138 SBP episodes: 19 in LT patients and 119 in non‐LT patients.

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