Hepatocyte nuclear factor 4α‐nuclear factor‐κB feedback circuit modulates liver cancer progression

Bei‐Fang Ning, Jin Ding, Jiao Liu, Chuan Yin, Wen‐Ping Xu, Wen‐Ming Cong, Qing Zhang, Fei Chen, Tao Han, Xing Deng, Pei‐Qin Wang, Cai‐Feng Jiang, Jun‐Ping Zhang, Xin Zhang, Hong‐Yang Wang, Wei‐Fen Xie – 18 April 2014 – Hepatocyte nuclear factor 4α (HNF4α) is a liver enriched transcription factor and is indispensable for liver development. However, the role of HNF4α in hepatocellular carcinoma (HCC) progression remains to be elucidated.

Transcriptional dynamics of bile salt export pump during pregnancy: Mechanisms and implications in intrahepatic cholestasis of pregnancy

Xiulong Song, Alexander Vasilenko, Yuan Chen, Leila Valanejad, Ruchi Verma, Bingfang Yan, Ruitang Deng – 11 April 2014 – Bile salt export pump (BSEP) is responsible for biliary secretion of bile acids, a rate‐limiting step in the enterohepatic circulation of bile acids and transactivated by nuclear receptor farnesoid X receptor (FXR). Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent disorder among diseases unique to pregnancy and primarily occurs in the third trimester of pregnancy, with a hallmark of elevated serum bile acids.

Etiology and mortality of spontaneous bacterial peritonitis in liver transplant recipients: A cohort study

Cristina Pérez‐Cameo, Víctor Vargas, Lluís Castells, Itxarone Bilbao, Isabel Campos‐Varela, Joan Gavaldà, Albert Pahissa, Oscar Len – 10 April 2014 – Spontaneous bacterial peritonitis (SBP) in liver transplantation (LT) recipients who progress to cirrhosis has received little attention. We investigated the adequacy of empirical treatment with third‐generation cephalosporins for SBP in this population and the impact of transplantation on the evolution of the infection. We performed a cohort study with 138 SBP episodes: 19 in LT patients and 119 in non‐LT patients.

Thymic stromal lymphopoietin and interleukin‐4 mediate the pathogenesis of halothane‐induced liver injury in mice

William R. Proctor, Mala Chakraborty, Aaron M. Fullerton, Midhun C. Korrapati, Pauline M. Ryan, Kenrick Semple, Jeffrey C. Morrison, Julia D. Berkson, Lynette S. Chea, Qian Yang, Albert P. Li, Rosanne Spolski, Erin E. West, Yrina Rochman, Warren J. Leonard, Mohammed Bourdi, Lance R. Pohl – 10 April 2014 – Liver eosinophilia has been associated with incidences of drug‐induced liver injury (DILI) for more than 50 years, although its role in this disease has remained largely unknown.

Helicobacter pylori might contribute to nonalcoholic fatty liver disease–related cardiovascular events by releasing prothrombotic and proinflammatory factors

Jannis Kountouras, Stergios A. Polyzos, Christos Zavos, Georgia Deretzi, Constantinos Kountouras, Elizabeth Vardaka, Panagiotis Katsinelos, Elena Tsiaousi, Nikolaos Grigoriadis, Iordanis Romiopoulos, Dimitrios Tzilves, Evangelia Giartza‐Taxidou – 10 April 2014

Phosphorylation of ABCB4 impacts its function: Insights from disease‐causing mutations

Julien Gautherot, Danièle Delautier, Marie‐Anne Maubert, Tounsia Aït‐Slimane, Gérard Bolbach, Jean‐Louis Delaunay, Anne‐Marie Durand‐Schneider, Delphine Firrincieli, Véronique Barbu, Nicolas Chignard, Chantal Housset, Michèle Maurice, Thomas Falguières – 10 April 2014 – The ABCB4 transporter mediates phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defects cause biliary diseases.

Index‐based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study

Wen‐Qing Li, Yikyung Park, Katherine A. McGlynn, Albert R. Hollenbeck, Philip R. Taylor, Alisa M. Goldstein, Neal D. Freedman – 9 April 2014 – The role of diet in hepatocellular carcinoma (HCC) and its typical precursor, chronic liver disease (CLD), is poorly understood. Following dietary recommendations has been shown to reduce risk of many cancers, but whether such diets are associated with HCC and CLD is unknown.

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