Hepatoprotective effect by pretreatment with olprinone in a swine partial hepatectomy model

Kohta Iguchi, Etsuro Hatano, Kenya Yamanaka, Motohiko Sato, Gen Yamamoto, Yosuke Kasai, Tatsuya Okamoto, Masayuki Okuno, Kojiro Taura, Kyoko Fukumoto, Kazuyuki Ueno, Shinji Uemoto – 4 April 2014 – Excessive portal flow to a small remnant liver or small‐for‐size graft is a primary factor of small‐for‐size syndrome. We demonstrated that olprinone (OLP), a phosphodiesterase III inhibitor, had a hepatoprotective effect in a rat extended hepatectomy model and a small‐for‐size liver transplantation model through a modification of the portal venous pressure (PVP).

Spectrum of statin hepatotoxicity: Experience of the drug‐induced liver injury network

Mark W. Russo, Jay H. Hoofnagle, Jiezhun Gu, Robert J. Fontana, Huiman Barnhart, David E. Kleiner, Naga Chalasani, Herbert L. Bonkovsky – 2 April 2014 – The HMG‐CoA reductase inhibitors (statins) are widely prescribed for patients with hyperlipidemia and are generally well tolerated. Mild elevations in serum aminotransferases arise in up to 3% of treated patients, but clinically apparent drug‐induced liver injury is rare. The aim of this study is to report the presenting features and outcomes of 22 patients with clinically apparent liver injury due to statins.

Assessment of alcohol consumption in liver transplant candidates and recipients: The best combination of the tools available

Salvatore Piano, Lucio Marchioro, Elisabetta Gola, Silvia Rosi, Filippo Morando, Marta Cavallin, Antonietta Sticca, Silvano Fasolato, Giovanni Forza, Anna Chiara Frigo, Mario Plebani, Giacomo Zanus, Umberto Cillo, Angelo Gatta, Paolo Angeli – 2 April 2014 – The detection of alcohol consumption in liver transplant candidates (LTCs) and liver transplant recipients (LTRs) is required to enable a proper assessment of transplant eligibility and early management of alcohol relapse, respectively.

Serum adipokine and inflammatory markers before and after liver transplantation in recipients with major cardiovascular events

Kymberly D. Watt, Chun Fan, Terry Therneau, Julie K. Heimbach, Eric C. Seaberg, Michael R. Charlton – 2 April 2014 – In the nontransplant setting, aberrant serum adipokine levels are associated with cardiovascular (CV) disease. The effects of liver transplantation (LT) on serum adipokine levels and their association with post‐LT CV disease have not been studied.

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