Jean‐François Dufour – 24 March 2014

Jean‐François Dufour – 24 March 2014

Sachin Batra, Victor I. Machicao, John S. Bynon, Shivang Mehta, Rajasekhar Tanikella, Michael J. Krowka, Steven Zacks, James Trotter, Kari E. Roberts, Robert S. Brown, Steven M. Kawut, Michael B. Fallon, for the Pulmonary Vascular Complications of Liver Disease Group – 22 March 2014 – Left ventricular hypertrophy (LVH) occurs in 12% to 30% of patients with cirrhosis; however, its prognostic significance is not well studied. We assessed the association of LVH with survival in patients undergoing a liver transplantation (LT) evaluation.

Moustafa Mabrouk Mourad, Christos Liossis, Bridget K. Gunson, Hynek Mergental, John Isaac, Paolo Muiesan, Darius F. Mirza, M. Thamara P. R. Perera, Simon R. Bramhall – 21 March 2014 – Hepatic artery thrombosis (HAT) represents a major cause of graft loss and mortality after liver transplantation. It occurs in up to 9% of adult recipients. The early diagnosis of HAT decreases septic complications, multiorgan failure, and graft loss, and there are better outcomes after treatment.

Haripriya Maddur, Patrick D. Bourdillon, Suthat Liangpunsakul, A. Joseph Tector, Jonathan A. Fridell, Marwan Ghabril, Marco A. Lacerda, Charlotte Bourdillon, Changyu Shen, Paul Y. Kwo – 20 March 2014 – Limited data regarding the optimal risk assessment strategy for evaluating candidates for orthotopic liver transplantation (OLT) exist.

Hani M. Wadei, Ilynn G. Bulatao, Thomas A. Gonwa, Martin L. Mai, Mary Prendergast, Andrew P. Keaveny, Barry G. Rosser, C. Burcin Taner – 20 March 2014 – Limited data are available for outcomes of simultaneous liver‐kidney (SLK) transplantation using donation after cardiac death (DCD) donors. The outcomes of 12 DCD‐SLK transplants and 54 SLK transplants using donation after brain death (DBD) donors were retrospectively compared.

Ramadan M. Gharbawy, Bakr M. Nour – 20 March 2014

Saira Khaderi, Rashid Khan, Zeenath Safdar, Rise Stribling, John M. Vierling, John A. Goss, Norman L. Sussman – 20 March 2014 – Portopulmonary hypertension (POPH) occurs in 5.3% to 8.5% of patients with advanced liver disease. The rate of survival in the absence of orthotopic liver transplantation (OLT) is reportedly 38% at 3 years and 28% at 5 years. Moderate to severe POPH [mean pulmonary artery pressure (MPAP) ≥ 35 mm Hg] is associated with a perioperative mortality rate of 50%.

Tim O. Lankisch, Torsten Voigtländer, Michael P. Manns, Angelika Holzmann, Seema Dangwal, Thomas Thum – 20 March 2014 – Biliary complications after liver transplantation remain a major cause of morbidity and reduced graft survival. Ischemic‐type biliary lesions (ITBLs) are common and difficult to treat. The pathophysiology of ITBLs remains unclear, and diagnostic markers are still missing. The analysis of microRNA (miRNA) profiles is an evolving field in hepatology. Our aim was to identify specific miRNA patterns in the bile of patients with ITBLs after liver transplantation.

Freimut Schliess, Stefan Hoehme, Sebastian G. Henkel, Ahmed Ghallab, Dominik Driesch, Jan Böttger, Reinhard Guthke, Michael Pfaff, Jan G. Hengstler, Rolf Gebhardt, Dieter Häussinger, Dirk Drasdo, Sebastian Zellmer – 19 March 2014 – The impairment of hepatic metabolism due to liver injury has high systemic relevance. However, it is difficult to calculate the impairment of metabolic capacity from a specific pattern of liver damage with conventional techniques. We established an integrated metabolic spatial‐temporal model (IM) using hepatic ammonia detoxification as a paradigm.