Tim O. Lankisch, Torsten Voigtländer, Michael P. Manns, Angelika Holzmann, Seema Dangwal, Thomas Thum – 20 March 2014 – Biliary complications after liver transplantation remain a major cause of morbidity and reduced graft survival. Ischemic‐type biliary lesions (ITBLs) are common and difficult to treat. The pathophysiology of ITBLs remains unclear, and diagnostic markers are still missing. The analysis of microRNA (miRNA) profiles is an evolving field in hepatology. Our aim was to identify specific miRNA patterns in the bile of patients with ITBLs after liver transplantation.

Saira Khaderi, Rashid Khan, Zeenath Safdar, Rise Stribling, John M. Vierling, John A. Goss, Norman L. Sussman – 20 March 2014 – Portopulmonary hypertension (POPH) occurs in 5.3% to 8.5% of patients with advanced liver disease. The rate of survival in the absence of orthotopic liver transplantation (OLT) is reportedly 38% at 3 years and 28% at 5 years. Moderate to severe POPH [mean pulmonary artery pressure (MPAP) ≥ 35 mm Hg] is associated with a perioperative mortality rate of 50%.

Ramadan M. Gharbawy, Bakr M. Nour – 20 March 2014

Hani M. Wadei, Ilynn G. Bulatao, Thomas A. Gonwa, Martin L. Mai, Mary Prendergast, Andrew P. Keaveny, Barry G. Rosser, C. Burcin Taner – 20 March 2014 – Limited data are available for outcomes of simultaneous liver‐kidney (SLK) transplantation using donation after cardiac death (DCD) donors. The outcomes of 12 DCD‐SLK transplants and 54 SLK transplants using donation after brain death (DBD) donors were retrospectively compared.

Haripriya Maddur, Patrick D. Bourdillon, Suthat Liangpunsakul, A. Joseph Tector, Jonathan A. Fridell, Marwan Ghabril, Marco A. Lacerda, Charlotte Bourdillon, Changyu Shen, Paul Y. Kwo – 20 March 2014 – Limited data regarding the optimal risk assessment strategy for evaluating candidates for orthotopic liver transplantation (OLT) exist.

Freimut Schliess, Stefan Hoehme, Sebastian G. Henkel, Ahmed Ghallab, Dominik Driesch, Jan Böttger, Reinhard Guthke, Michael Pfaff, Jan G. Hengstler, Rolf Gebhardt, Dieter Häussinger, Dirk Drasdo, Sebastian Zellmer – 19 March 2014 – The impairment of hepatic metabolism due to liver injury has high systemic relevance. However, it is difficult to calculate the impairment of metabolic capacity from a specific pattern of liver damage with conventional techniques. We established an integrated metabolic spatial‐temporal model (IM) using hepatic ammonia detoxification as a paradigm.

Kheng Choon Lim, Vivian W. Wang, Fahad J. Siddiqui, Luming Shi, Edwin S.Y. Chan, Hong Choon Oh, Say Beng Tan, Pierce K.H. Chow – 18 March 2014 – Both liver resection (LR) and cadaveric liver transplantation (CLT) are potentially curative treatments for patients with hepatocellular carcinoma (HCC) within the Milan criteria and with adequate liver function. Adopting either as a first‐line therapy carries major cost and resource implications.

Srinivasan Dasarathy – 18 March 2014

Gao Feng, Chen Jing, Zeng Qian, Guan Jun, Huang Danni – 17 March 2014

Mitra K. Nadim, Wanwarat Annanthapanyasut, Lea Matsuoka, Kari Appachu, Mark Boyajian, Lingyun Ji, Ashraf Sedra, Yuri S. Genyk – 17 March 2014 – Liver transplantation (LT) for patients with renal dysfunction is frequently complicated by major fluid shifts, acidosis, and electrolyte and coagulation abnormalities. Continuous renal replacement therapy (CRRT) has been previously shown to ameliorate these problems. We describe the safety and clinical outcomes of intraoperative hemodialysis (IOHD) during LT for a group of patients with high Model for End‐Stage Liver Disease (MELD) scores.