Richard J. Thompson, A.S. Knisely – 26 March 2014

Linda G. Griffith, Alan Wells, Donna B. Stolz – 26 March 2014 – Interest in “engineering liver” arises from multiple communities: therapeutic replacement; mechanistic models of human processes; and drug safety and efficacy studies.

Karin E. Koopman, Matthan W.A. Caan, Aart J. Nederveen, Anouk Pels, Mariette T. Ackermans, Eric Fliers, Susanne E. Fleur, Mireille J. Serlie – 26 March 2014 – American children consume up to 27% of calories from high‐fat and high‐sugar snacks. Both sugar and fat consumption have been implicated as a cause of hepatic steatosis and obesity but the effect of meal pattern is largely understudied. We hypothesized that a high meal frequency, compared to consuming large meals, is detrimental in the accumulation of intrahepatic and abdominal fat.

Hyon‐Seung Yi, Young‐Sun Lee, Jin‐Seok Byun, Wonhyo Seo, Jong‐Min Jeong, Ogyi Park, Gregg Duester, Takeshi Haseba, Sun Chang Kim, Keun‐Gyu Park, Bin Gao, Won‐Il Jeong – 26 March 2014 – The important roles of retinols and their metabolites have recently been emphasized in the interactions between hepatic stellate cells (HSCs) and natural killer (NK) cells. Nevertheless, the expression and role of retinol metabolizing enzyme in both cell types have yet to be clarified. Thus, we investigated the expression of retinol metabolizing enzyme and its role in liver fibrosis.

Antonio Riva, Melissa Laird, Armanda Casrouge, Arvydas Ambrozaitis, Roger Williams, Nikolai V. Naoumov, Matthew L. Albert, Shilpa Chokshi – 26 March 2014 – The pathogenesis of hepatitis C virus (HCV) infection is strongly influenced by the nature of the host's antiviral immunity. Counterintuitively, elevated serum concentrations of C‐X‐C chemokine 10 (CXCL10), a potent chemoattractant for antiviral T‐cells and NK‐cells, are associated with poor treatment outcomes in patients with chronic HCV.

Suk‐Won Suh, Jeong‐Moo Lee, Tae You, Young Rok Choi, Nam‐Joon Yi, Kwang‐Woong Lee, Kyung‐Suk Suh – 25 March 2014 – A certain degree of graft congestion in living donor liver transplantation (LDLT) using a right liver graft may be inevitable because of the mismatch between the inflow and outflow structures of the liver. The subsequent inflammatory reaction and rapid regeneration of the graft have been suggested as causes of tumor recurrence. Therefore, we investigated the influence of graft congestion on hepatocellular carcinoma (HCC) recurrence after LDLT.

Takeo Toshima, Ken Shirabe, Takasuke Fukuhara, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Tetsuo Ikeda, Shinji Okano, Yoshihiko Maehara – 25 March 2014 – Autophagy is a homeostatic mechanism that regulates protein and organelle turnover and uses the amino acids from degraded proteins to produce adenosine 5'‐triphosphate (ATP). We investigated the activity of autophagy‐associated pathways in liver regeneration after partial hepatectomy (PHx) in liver‐specific autophagy‐related gene 5 (Atg5) knockout (KO) mice.

Erica F. Clayton, Saloni Malik, Alexander Bonnel, Yifei Mu, Kim Olthoff, Abraham Shaked, Peter L. Abt, Heather Peterman, K. Rajender Reddy, Shane Ottmann, Emma E. Furth, Matthew H. Levine – 25 March 2014 – Liver transplantation has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC) that falls within certain size and numerical criteria for patients with cirrhosis. Cirrhotomimetic (CMM) HCC is an uncommon growth pattern that infiltrates cirrhotic parenchyma, can become extensive in size, and can evade detection via radiological studies.

Irene Locatelli, Salvatore Sutti, Aastha Jindal, Marco Vacchiano, Cristina Bozzola, Chris Reutelingsperger, Dennis Kusters, Stefania Bena, Maurizio Parola, Claudia Paternostro, Elisabetta Bugianesi, Simon McArthur, Emanuele Albano, Mauro Perretti – 25 March 2014 – Annexin A1 (AnxA1) is an effector of the resolution of inflammation and is highly effective in terminating acute inflammatory responses. However, its role in chronic settings is less investigated.

Ricardo Marcos, Carla Correia‐Gomes – 25 March 2014