Prevalence and natural history of histologically proven chronic liver disease in a longitudinal cohort of patients with type 1 diabetes

David J. Harman, Philip V. Kaye, Rebecca Harris, Ayako Suzuki, Anastasios Gazis, Guruprasad P. Aithal – 28 February 2014 – Although a higher prevalence of raised liver enzymes and altered echotexture on ultrasound have been reported in patients with type 1 diabetes mellitus (T1DM), the histological spectrum and natural history of chronic liver disease (CLD) in T1DM is unknown. We investigated the prevalence and outcome of histologically proven CLD in a longitudinal cohort of patients with T1DM.

Prevalence and natural history of histologically proven chronic liver disease in a longitudinal cohort of patients with type 1 diabetes

David J. Harman, Philip V. Kaye, Rebecca Harris, Ayako Suzuki, Anastasios Gazis, Guruprasad P. Aithal – 28 February 2014 – Although a higher prevalence of raised liver enzymes and altered echotexture on ultrasound have been reported in patients with type 1 diabetes mellitus (T1DM), the histological spectrum and natural history of chronic liver disease (CLD) in T1DM is unknown. We investigated the prevalence and outcome of histologically proven CLD in a longitudinal cohort of patients with T1DM.

Polysialic acid/neural cell adhesion molecule modulates the formation of ductular reactions in liver injury

Atsunori Tsuchiya, Wei‐Yu Lu, Birgit Weinhold, Luke Boulter, Benjamin M. Stutchfield, Michael J. Williams, Rachel V. Guest, Sarah E. Minnis‐Lyons, Alison C. MacKinnon, David Schwarzer, Takafumi Ichida, Minoru Nomoto, Yutaka Aoyagi, Rita Gerardy‐Schahn, Stuart J. Forbes – 28 February 2014 – In severe liver injury, ductular reactions (DRs) containing bipotential hepatic progenitor cells (HPCs) branch from the portal tract. Neural cell adhesion molecule (NCAM) marks bile ducts and DRs, but not mature hepatocytes.

Computerized physician order entry‐based system to prevent HBV reactivation in patients treated with biologic agents: The PRESCRIB project

Blanca Sampedro, Cándido Hernández‐López, José Ramón Ferrandiz, Aitziber Illaro, Emilio Fábrega, Antonio Cuadrado, Paula Iruzubieta, Susana Menéndez, Joaquín Cabezas, Javier Crespo – 28 February 2014 – Computerized physician order entry (CPOE) applications are widely used to prevent medical errors. In our center, a CPOE system has been in use since 2009 on both the inpatient and outpatient levels.

Late HDV RNA relapse after peginterferon alpha‐based therapy of chronic hepatitis delta

Benjamin Heidrich, Cihan Yurdaydın, Gökhan Kabaçam, Boris A. Ratsch, Kalliopi Zachou, Birgit Bremer, George N. Dalekos, Andreas Erhardt, Fehmi Tabak, Kendal Yalcin, Selim Gürel, Stefan Zeuzem, Markus Cornberg, C.‐Thomas Bock, Michael P. Manns, Heiner Wedemeyer, HIDIT‐1 Study Group – 28 February 2014 – Interferon alpha is the only treatment option for hepatitis delta virus (HDV). Trials investigating the efficacy of pegylated interferon alpha (PEG‐IFNa) showed HDV RNA negativity rates of 25‐30% 24 weeks after therapy.

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