Health‐related quality of life: Two decades after liver transplantation

Kara M. Sullivan, David M. Radosevich, John R. Lake – 21 February 2014 – In this study, we describe a cohort of patients who received liver transplants before January 1, 1989 at the University of Minnesota Medical Center (UMMC), and we evaluate the health‐related quality of life (HRQOL) of the survivors of this group. One hundred sixty‐one patients—66 adults and 95 children—received whole deceased donor liver transplants.

Donor‐specific alloantibodies are associated with fibrosis progression after liver transplantation in hepatitis C virus–infected patients

Jacqueline G. O'Leary, Hugo Kaneku, Linda Jennings, Brian M. Susskind, Paul I. Terasaki, Göran B. Klintmalm – 21 February 2014 – Hepatitis C virus (HCV) fibrosis progression after liver transplantation (LT) is accelerated in comparison with fibrosis progression before transplantation. The vast majority of the risk factors for fibrosis progression after LT are not modifiable.

Survival in infection‐related acute‐on‐chronic liver failure is defined by extrahepatic organ failures

Jasmohan S. Bajaj, Jacqueline G. O'Leary, K. Rajender Reddy, Florence Wong, Scott W. Biggins, Heather Patton, Michael B. Fallon, Guadalupe Garcia‐Tsao, Benedict Maliakkal, Raza Malik, Ram M. Subramanian, Leroy R. Thacker, Patrick S. Kamath, the North American Consortium for the Study of End-stage Liver Disease (NACSELD) – 20 February 2014 – Infections worsen survival in cirrhosis; however, simple predictors of survival in infection‐related acute‐on‐chronic liver failure (I‐ACLF) derived from multicenter studies are required in order to improve prognostication and resource allocation.

The biliary epithelium gives rise to liver progenitor cells

Daniel Rodrigo‐Torres, Silvia Affò, Mar Coll, Oriol Morales‐Ibanez, Cristina Millán, Delia Blaya, Anna Alvarez‐Guaita, Carles Rentero, Juan José Lozano, Miguel Angel Maestro, Myriam Solar, Vicente Arroyo, Joan Caballería, Leo A. van Grunsven, Carlos Enrich, Pere Ginès, Ramon Bataller, Pau Sancho‐Bru – 20 February 2014 – Severe liver diseases are characterized by expansion of liver progenitor cells (LPC), which correlates with disease severity. However, the origin and role of LPC in liver physiology and in hepatic injury remains a contentious topic.

Prediagnostic circulating vitamin D levels and risk of hepatocellular carcinoma in European populations: A nested case‐control study

Veronika Fedirko, Talita Duarte‐Salles, Christina Bamia, Antonia Trichopoulou, Krasimira Aleksandrova, Dimitrios Trichopoulos, Elisabeth Trepo, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie‐Christine Boutron‐Ruault, Françoise Clavel‐Chapelon, Marina Kvaskoff, Tilman Kühn, Annie Lukanova, Heiner Boeing, Brian Buijsse, Eleni Klinaki, Chrysanthi Tsimakidi, Alessio Naccarati, Giovanna Tagliabue, Salvatore Panico, Rosario Tumino, Domenico Palli, H. Bas Bueno‐de‐Mesquita, Peter D. Siersema, Petra H.

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