Polysialic acid/neural cell adhesion molecule modulates the formation of ductular reactions in liver injury

Atsunori Tsuchiya, Wei‐Yu Lu, Birgit Weinhold, Luke Boulter, Benjamin M. Stutchfield, Michael J. Williams, Rachel V. Guest, Sarah E. Minnis‐Lyons, Alison C. MacKinnon, David Schwarzer, Takafumi Ichida, Minoru Nomoto, Yutaka Aoyagi, Rita Gerardy‐Schahn, Stuart J. Forbes – 28 February 2014 – In severe liver injury, ductular reactions (DRs) containing bipotential hepatic progenitor cells (HPCs) branch from the portal tract. Neural cell adhesion molecule (NCAM) marks bile ducts and DRs, but not mature hepatocytes.

Prevalence and natural history of histologically proven chronic liver disease in a longitudinal cohort of patients with type 1 diabetes

David J. Harman, Philip V. Kaye, Rebecca Harris, Ayako Suzuki, Anastasios Gazis, Guruprasad P. Aithal – 28 February 2014 – Although a higher prevalence of raised liver enzymes and altered echotexture on ultrasound have been reported in patients with type 1 diabetes mellitus (T1DM), the histological spectrum and natural history of chronic liver disease (CLD) in T1DM is unknown. We investigated the prevalence and outcome of histologically proven CLD in a longitudinal cohort of patients with T1DM.

Prevalence and natural history of histologically proven chronic liver disease in a longitudinal cohort of patients with type 1 diabetes

David J. Harman, Philip V. Kaye, Rebecca Harris, Ayako Suzuki, Anastasios Gazis, Guruprasad P. Aithal – 28 February 2014 – Although a higher prevalence of raised liver enzymes and altered echotexture on ultrasound have been reported in patients with type 1 diabetes mellitus (T1DM), the histological spectrum and natural history of chronic liver disease (CLD) in T1DM is unknown. We investigated the prevalence and outcome of histologically proven CLD in a longitudinal cohort of patients with T1DM.

Treatment of phenylketonuria using minicircle‐based naked‐DNA gene transfer to murine liver

Hiu Man Viecelli, Richard P. Harbottle, Suet Ping Wong, Andrea Schlegel, Marinee K. Chuah, Thierry VandenDriessche, Cary O. Harding, Beat Thöny – 28 February 2014 – Host immune response to viral vectors, persistence of nonintegrating vectors, and sustained transgene expression are among the major challenges in gene therapy. To overcome these hurdles, we successfully used minicircle (MC) naked‐DNA vectors devoid of any viral or bacterial sequences for the long‐term treatment of murine phenylketonuria, a model for a genetic liver defect.

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