Ribavirin improves the IFN‐γ response of natural killer cells to IFN‐based therapy of hepatitis C virus infection

Jens M. Werner, Elisavet Serti, Xenia Chepa‐Lotrea, Jonathan Stoltzfus, Golo Ahlenstiel, Mazen Noureddin, Jordan J. Feld, T. Jake Liang, Yaron Rotman, Barbara Rehermann – 23 February 2014 – Ribavirin (RBV) is an important component of interferon (IFN)‐based and direct antiviral treatment regimens for hepatitis C virus (HCV) infection. Immunomodulation, in particular improvement of the host IFN response, has been proposed as RBV's mechanism of action.

Gd‐EOB‐DTPA‐enhanced magnetic resonance imaging and alpha‐fetoprotein predict prognosis of early‐stage hepatocellular carcinoma

Taro Yamashita, Azusa Kitao, Osamu Matsui, Takehiro Hayashi, Kouki Nio, Mitsumasa Kondo, Naoki Ohno, Tosiaki Miyati, Hikari Okada, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Yasuni Nakanuma, Hiroyuki Takamura, Tetsuo Ohta, Yasunari Nakamoto, Masakazu Yamamoto, Tadatoshi Takayama, Shigeki Arii, XinWei Wang, Shuichi Kaneko – 23 February 2014 – The survival of patients with hepatocellular carcinoma (HCC) is often individually different even after surgery for early‐stage tumors.

Liver transplantation in the management of porphyria

Ashwani K. Singal, Charles Parker, Christine Bowden, Manish Thapar, Lawrence Liu, Brendan M. McGuire – 22 February 2014 – Porphyrias are a group of eight metabolic disorders, each resulting from a mutation that affects an enzyme of the heme biosynthetic pathway. Porphyrias are classified as hepatic or erythropoietic, depending upon the site where the gene defect is predominantly expressed.

Role of protein kinase C isoforms in bile formation and cholestasis

M. Sawkat Anwer – 22 February 2014 – Transhepatic solute transport provides the osmotic driving force for canalicular bile formation. Choleretic and cholestatic agents affect bile formation, in part, by altering plasma membrane localizations of transporters involved in bile formation. These short‐term dynamic changes in transporter location are highly regulated posttranslational events requiring various cellular signaling pathways.

Role of protein kinase C isoforms in bile formation and cholestasis

M. Sawkat Anwer – 22 February 2014 – Transhepatic solute transport provides the osmotic driving force for canalicular bile formation. Choleretic and cholestatic agents affect bile formation, in part, by altering plasma membrane localizations of transporters involved in bile formation. These short‐term dynamic changes in transporter location are highly regulated posttranslational events requiring various cellular signaling pathways.

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