Restoration of portal flow using a pericholedochal varix in adult living donor liver transplantation for patients with total portosplenomesenteric thrombosis

Deok‐Bog Moon, Sung‐Gyu Lee, Chul‐Soo Ahn, Shin Hwang, Ki‐Hun Kim, Tae‐Yong Ha, Gi‐Won Song, Gil‐Chun Park, Dong‐Hwan Jung, Jung‐Man Namkoong, Hyung‐Woo Park, Yo‐Han Park – 7 February 2014 – In total portosplenomesenteric thrombosis patients, cavoportal hemitransposition (CPHT) is indicated but rarely applicable for adult‐to‐adult (A‐to‐A) living donor liver transplantation (LDLT) because partial liver graft requires splanchno‐portal inflow for liver graft regeneration.

Fibroblast growth factor 21 protects against acetaminophen‐induced hepatotoxicity by potentiating peroxisome proliferator‐activated receptor coactivator protein‐1α‐mediated antioxidant capacity in mice

Dewei Ye, Yudong Wang, Huating Li, Weiping Jia, Kwan Man, Chung Mau Lo, Yu Wang, Karen S.L. Lam, Aimin Xu – 6 February 2014 – Acetaminophen (APAP) overdose is a leading cause of drug‐induced hepatotoxicity and acute liver failure worldwide, but its pathophysiology remains incompletely understood. Fibroblast growth factor 21 (FGF21) is a hepatocyte‐secreted hormone with pleiotropic effects on glucose and lipid metabolism. This study aimed to investigate the pathophysiological role of FGF21 in APAP‐induced hepatotoxicity in mice.

Coffee, alcohol and other beverages in relation to cirrhosis mortality: The Singapore Chinese Health Study

George Boon‐Bee Goh, Wan‐Cheng Chow, Renwei Wang, Jian‐Min Yuan, Woon‐Puay Koh – 6 February 2014 – Limited experimental and epidemiologic data suggest that coffee may reduce hepatic damage in chronic liver disease. The association between consumption of coffee and other beverages and risk of cirrhosis mortality was evaluated in the Singapore Chinese Health Study.

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