Martina Panattoni, Laura Maiorino, Anna Lukacs, Lorena Zentilin, Davide Mazza, Francesca Sanvito, Giovanni Sitia, Luca G. Guidotti, Ruggero Pardi – 22 January 2014 – Aberrant DNA replication induced by deregulated or excessive proliferative stimuli evokes a “replicative stress response” leading to cell cycle restriction and/or apoptosis. This robust fail‐safe mechanism is eventually bypassed by transformed cells, due to ill‐defined epistatic interactions.

Edoardo G. Giannini, R. Todd Stravitz, Stephen H. Caldwell – 22 January 2014

Jordi Gracia‐Sancho, Virginia Hernández‐Gea, Juan Carlos Garcia‐Pagán – 22 January 2014

José M. Mato, M. Luz Martínez‐Chantar, Shelly C. Lu – 21 January 2014 – Medicine is expected to benefit from combining usual cellular and molecular studies with high‐throughput methods (genomics, transcriptomics, proteomics, and metabolomics). These methods, collectively known as omics, permit the determination of thousands of molecules (variations within genes, RNAs, proteins, metabolites) within a tissue, cell, or biological fluid. The use of these methods is very demanding in terms of the design of the study, acquisition, storage, analysis, and interpretation of the data.

Jacinta A. Holmes, Stuart K. Roberts, Rachel J. Ali, Gregory J. Dore, William Sievert, Geoffrey W. McCaughan, Darrell H. Crawford, Wendy S. Cheng, Martin D. Weltman, Sara Bonanzinga, Kumar Visvanathan, Vijaya Sundararajan, Paul V. Desmond, D. Scott Bowden, Gail V. Matthews, Alexander J. Thompson, on behalf of the CHARIOT Study Group – 21 January 2014 – On‐treatment anemia is associated with higher sustained virological response (SVR) rates during peginterferon plus ribavirin (RBV) therapy.

José M. Mato, M. Luz Martínez‐Chantar, Shelly C. Lu – 21 January 2014 – Medicine is expected to benefit from combining usual cellular and molecular studies with high‐throughput methods (genomics, transcriptomics, proteomics, and metabolomics). These methods, collectively known as omics, permit the determination of thousands of molecules (variations within genes, RNAs, proteins, metabolites) within a tissue, cell, or biological fluid. The use of these methods is very demanding in terms of the design of the study, acquisition, storage, analysis, and interpretation of the data.

Laura Milazzo, Anna Maria Peri, Lucia Lodi, Guido Gubertini, Anna Lisa Ridolfo, Spinello Antinori – 21 January 2014 – Primary intestinal lymphangiectasia (PIL) is a protein‐losing enteropathy characterized by tortuous and dilated lymph channels of the small bowel. The main symptoms are bilateral lower limb edema, serosal effusions, and vitamin D malabsorption resulting in osteoporosis. We report here a case of long‐lasting misdiagnosed PIL with a peculiar liver picture, characterized by a very high stiffness value at transient elastography, which decreased with clinical improvement.

Chiara Raggi, Valentina M. Factor, Daekwan Seo, Agnes Holczbauer, Matthew C. Gillen, Jens U. Marquardt, Jesper B. Andersen, Marian Durkin, Snorri S. Thorgeirsson – 21 January 2014 – Reversal of DNA hypermethylation and associated gene silencing is an emerging cancer therapy approach. Here we addressed the impact of epigenetic alterations and cellular context on functional and transcriptional reprogramming of hepatocellular carcinoma (HCC) cells.

Laura Milazzo, Anna Maria Peri, Lucia Lodi, Guido Gubertini, Anna Lisa Ridolfo, Spinello Antinori – 21 January 2014 – Primary intestinal lymphangiectasia (PIL) is a protein‐losing enteropathy characterized by tortuous and dilated lymph channels of the small bowel. The main symptoms are bilateral lower limb edema, serosal effusions, and vitamin D malabsorption resulting in osteoporosis. We report here a case of long‐lasting misdiagnosed PIL with a peculiar liver picture, characterized by a very high stiffness value at transient elastography, which decreased with clinical improvement.

Nils Jedicke, Nina Struever, Nupur Aggrawal, Tobias Welte, Michael P. Manns, Nisar P. Malek, Lars Zender, Sabina Janciauskiene, Torsten Wuestefeld – 21 January 2014 – Acute liver failure remains a critical clinical condition, with high mortality rates, and increased apoptosis of hepatocytes represents a key event in the cause of liver failure. Alpha‐1‐antitrypsin (AAT) is synthesized and secreted mainly by hepatocytes, and plasma purified AAT is used for augmentation therapy in patients with AAT deficiency.