Techniques for safe organ recovery after endovascular aortic and bariatric operations
Laurence J. Belin, Robert C. Neely, Michael D. Kluger – 3 February 2014
Plasmacytoid dendritic cell‐derived IFN‐α promotes murine liver ischemia/reperfusion injury by induction of hepatocyte IRF‐1
Antonino Castellaneta, Osamu Yoshida, Shoko Kimura, Shinichiro Yokota, David A. Geller, Noriko Murase, Angus W. Thomson – 3 February 2014 – Plasmacytoid dendritic cells (pDC) constitute the body's principal source of type I interferon (IFN) and are comparatively abundant in the liver. Among various cytokines implicated in liver ischemia and reperfusion (I/R) injury, type I IFNs have been described recently as playing an essential role in its pathogenesis.
Sticker shock and the price of new therapies for hepatitis C: Is it worth it?
Nancy S. Reau, Donald M. Jensen – 3 February 2014
Intrahepatic cholestasis of pregnancy and the risk of subsequent hepatobiliary disorders
Humberto Reyes – 3 February 2014
Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury
Ingrid Lua, David James, Jiaohong Wang, Kasper S. Wang, Kinji Asahina – 1 February 2014 – Hepatic stellate cells (HSCs) and portal fibroblasts (PFs) are believed to be the major source of myofibroblasts that participate in fibrogenesis by way of synthesis of proinflammatory cytokines and extracellular matrices. Previous lineage tracing studies using MesP1Cre and Rosa26lacZflox mice demonstrated that MesP1+ mesoderm gives rise to mesothelial cells (MCs), which differentiate into HSCs and PFs during liver development.
Reply
Kristopher Croome, Roberto Hernandez‐Alejandro – 31 January 2014
Clinical implications of preoperative and intraoperative liver biopsies for evaluating donor steatosis in living related liver transplantation
Mi‐Jung Jun, Ju Hyun Shim, So Yeon Kim, Nieun Seo, Kang Mo Kim, Young‐Suk Lim, Han Chu Lee, Eunsil Yu, Sung‐Gyu Lee – 30 January 2014 – The role of liver biopsy in selecting optimal donors is an area of continuing controversy in living donor liver transplantation (LDLT). Our aim was to assess the potential implications of preoperative and intraoperative biopsies for evaluating donor liver fat content.
Operative outcomes of adult living donor liver transplantation and deceased donor liver transplantation: A systematic review and meta‐analysis
Ping Wan, Xin Yu, Qiang Xia – 30 January 2014 – Living donor liver transplantation (LDLT) has emerged as an alternative to deceased donor liver transplantation (DDLT) because of the increasing number of patients waiting for liver transplantation (LT). However, whether it can achieve operative outcomes similar to those achieved with DDLT for adult patients remains controversial. We conducted this meta‐analysis to compare the operative outcomes of LDLT and DDLT recipients.
Pregnancy outcomes after living donor liver transplantation: Results from a Japanese survey
Shoji Kubo, Shinji Uemoto, Hiroyuki Furukawa, Koji Umeshita, Daisuke Tachibana, for the Japanese Liver Transplantation Society – 30 January 2014 – A national survey of pregnancy outcomes after living donor liver transplantation (LDLT) was performed in Japan. Thirty‐eight pregnancies in 30 recipients resulted in 31 live births (25 recipients), 3 artificial abortions in the first trimester (3 recipients), 1 spontaneous abortion (1 recipient), and 3 fetal deaths (3 recipients).
No increase in blood transfusions during liver transplantation since the withdrawal of aprotinin
Nick Schofield, Anita Sugavanam, Karen Thompson, Susan V. Mallett – 30 January 2014 – The aims of this study were to determine whether the withdrawal of aprotinin (APRO) led to an increased bleeding risk in patients undergoing orthotopic liver transplantation (OLT). A retrospective analysis compared consecutive patients undergoing OLT and treated with aprotinin (APRO group; n = 100) with a group in which aprotinin was not used (no‐APRO group; n = 100). Propensity score matching was then performed for each group to identify 2 matched cohorts.