Survival in infection‐related acute‐on‐chronic liver failure is defined by extrahepatic organ failures

Jasmohan S. Bajaj, Jacqueline G. O'Leary, K. Rajender Reddy, Florence Wong, Scott W. Biggins, Heather Patton, Michael B. Fallon, Guadalupe Garcia‐Tsao, Benedict Maliakkal, Raza Malik, Ram M. Subramanian, Leroy R. Thacker, Patrick S. Kamath, the North American Consortium for the Study of End-stage Liver Disease (NACSELD) – 20 February 2014 – Infections worsen survival in cirrhosis; however, simple predictors of survival in infection‐related acute‐on‐chronic liver failure (I‐ACLF) derived from multicenter studies are required in order to improve prognostication and resource allocation.

Beta‐catenin signaling in murine liver zonation and regeneration: A Wnt‐Wnt situation!

Jing Yang, Laura E. Mowry, Kari Nichole Nejak‐Bowen, Hirohisa Okabe, Cassandra R. Diegel, Richard A. Lang, Bart O. Williams, Satdarshan P. Monga – 20 February 2014 – Liver‐specific β‐catenin knockout (β‐Catenin‐LKO) mice have revealed an essential role of β‐catenin in metabolic zonation where it regulates pericentral gene expression and in initiating liver regeneration (LR) after partial hepatectomy (PH), by regulating expression of Cyclin‐D1. However, what regulates β‐catenin activity in these events remains an enigma.

Distinct seromarkers predict different milestones of chronic hepatitis B progression

Jessica Liu, Hwai‐I Yang, Mei‐Hsuan Lee, Richard Batrla‐Utermann, Chin‐Lan Jen, Sheng‐Nan Lu, Li‐Yu Wang, San‐Lin You, Chuhsing Kate Hsiao, Chien‐Jen Chen, the R.E.V.E.A.L.‐HBV Study Group – 20 February 2014 – Spontaneous seroclearance of hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA undetectability are important milestones of chronic hepatitis B and major treatment endpoints of antiviral therapy. This study investigated the role of serum hepatitis B surface antigen (HBsAg) levels and established models for predicting HBeAg seroclearance and HBV DNA undetectability.

Prediagnostic circulating vitamin D levels and risk of hepatocellular carcinoma in European populations: A nested case‐control study

Veronika Fedirko, Talita Duarte‐Salles, Christina Bamia, Antonia Trichopoulou, Krasimira Aleksandrova, Dimitrios Trichopoulos, Elisabeth Trepo, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie‐Christine Boutron‐Ruault, Françoise Clavel‐Chapelon, Marina Kvaskoff, Tilman Kühn, Annie Lukanova, Heiner Boeing, Brian Buijsse, Eleni Klinaki, Chrysanthi Tsimakidi, Alessio Naccarati, Giovanna Tagliabue, Salvatore Panico, Rosario Tumino, Domenico Palli, H. Bas Bueno‐de‐Mesquita, Peter D. Siersema, Petra H.

The biliary epithelium gives rise to liver progenitor cells

Daniel Rodrigo‐Torres, Silvia Affò, Mar Coll, Oriol Morales‐Ibanez, Cristina Millán, Delia Blaya, Anna Alvarez‐Guaita, Carles Rentero, Juan José Lozano, Miguel Angel Maestro, Myriam Solar, Vicente Arroyo, Joan Caballería, Leo A. van Grunsven, Carlos Enrich, Pere Ginès, Ramon Bataller, Pau Sancho‐Bru – 20 February 2014 – Severe liver diseases are characterized by expansion of liver progenitor cells (LPC), which correlates with disease severity. However, the origin and role of LPC in liver physiology and in hepatic injury remains a contentious topic.

Survival in infection‐related acute‐on‐chronic liver failure is defined by extrahepatic organ failures

Jasmohan S. Bajaj, Jacqueline G. O'Leary, K. Rajender Reddy, Florence Wong, Scott W. Biggins, Heather Patton, Michael B. Fallon, Guadalupe Garcia‐Tsao, Benedict Maliakkal, Raza Malik, Ram M. Subramanian, Leroy R. Thacker, Patrick S. Kamath, the North American Consortium for the Study of End-stage Liver Disease (NACSELD) – 20 February 2014 – Infections worsen survival in cirrhosis; however, simple predictors of survival in infection‐related acute‐on‐chronic liver failure (I‐ACLF) derived from multicenter studies are required in order to improve prognostication and resource allocation.

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