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Ling Yang, Ekihiro Seki – 17 January 2014
Opposite association between diabetes, dyslipidemia, and hepatocellular carcinoma mortality in the middle‐aged and elderly
Chien‐Hsieh Chiang, Long‐Teng Lee, Shou‐Hung Hung, Wen‐Yuan Lin, Hui‐Fang Hung, Wei‐Shiung Yang, Pei‐Kun Sung, Kuo‐Chin Huang – 15 January 2014 – Limited data exist regarding metabolic risk factors for deaths from hepatocellular carcinoma (HCC) in aging individuals. We investigated the association between diabetes, dyslipidemia, and HCC mortality in those aged 40 years or more (middle‐aged and elderly).
Potential role of oxidative DNA damage in the impact of PNPLA3 variant (rs 738409 C>G) in hepatocellular carcinoma risk
Emeric Limagne, Vanessa Cottet, Alexia Karen Cotte, Samia Hamza, Patrick Hillon, Norbert Latruffe, Dominique Delmas, for the CiRCE Study Group – 15 January 2014
Hepatorenal syndrome type 1 and bacterial infection: A catastrophic association in patients with cirrhosis
Francesco Salerno, Valentina Monti – 15 January 2014
Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses
William O. Osburn, Anna E. Snider, Brittany L. Wells, Rachel Latanich, Justin R. Bailey, David L. Thomas, Andrea L. Cox, Stuart C. Ray – 15 January 2014 – The contribution of humoral immune responses to spontaneous control of hepatitis C virus (HCV) infection remains unclear. We assessed neutralizing antibody (nAb) responses during acute HCV infection to determine whether infection outcome is associated with the nAb response, specifically, its timing or breadth (neutralization of multiple genotype‐matched variants).
Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A‐dependent sterol regulatory element binding protein1c degradation
Jae Ho Lee, Gha Young Lee, Hagoon Jang, Sung Sik Choe, Seung‐Hoi Koo, Jae Bum Kim – 15 January 2014 – Sterol regulatory element binding protein1c (SREBP1c) is a key transcription factor for de novo lipogenesis during the postprandial state. During nutritional deprivation, hepatic SREBP1c is rapidly suppressed by fasting signals to prevent lipogenic pathways. However, the molecular mechanisms that control SREBP1c turnover in response to fasting status are not thoroughly understood.
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Stefano Romeo, Luca Valenti, Eric Trépo, Christophe Moreno, Pierre Nahon, Pierre Deltenre – 15 January 2014
Clinical significance of the ubiquitin ligase UBE3C in hepatocellular carcinoma revealed by exome sequencing
Jia‐Hao Jiang, Yan‐Feng Liu, Ai‐Wu Ke, Fang‐Ming Gu, Yao Yu, Zhi Dai, Qiang Gao, Guo‐Ming Shi, Bo‐Yi Liao, You‐Hua Xie, Jia Fan, Xiao‐Wu Huang, Jian Zhou – 15 January 2014 – Virus‐induced hepatocarcinogenesis involves a series of histological developmental processes with the stepwise acquisition of several genetic changes that are necessary for the malignant transformation of hepatocytes. Although genetic alterations are known to be involved in the pathogenesis of hepatocellular carcinoma (HCC), little is known about the contributions of specific genes to this process.
Hepatorenal syndrome type 1 and bacterial infection: A catastrophic association in patients with cirrhosis
Francesco Salerno, Valentina Monti – 15 January 2014
Effect of pure microsteatosis on transplant outcomes after living donor liver transplantation: A matched case‐control study
Sangbin Han, Justin Sangwook Ko, Gheeyoung Kwon, Cheolkeun Park, Sanghoon Lee, Jongman Kim, Gaabsoo Kim, Choonhyuck David Kwon, Misook Gwak, Sangyun Ha – 14 January 2014 – Liver steatosis mostly exists in a mixed form of macrosteatosis (MaS) and microsteatosis (MiS). This coexistence is responsible for previous conflicting results regarding the importance of MiS in liver transplantation. We aimed to evaluate the independent effect of MiS on posttransplant outcomes with the exclusion of the confounding effect of MaS.