Francesco Salerno, Valentina Monti – 15 January 2014

William O. Osburn, Anna E. Snider, Brittany L. Wells, Rachel Latanich, Justin R. Bailey, David L. Thomas, Andrea L. Cox, Stuart C. Ray – 15 January 2014 – The contribution of humoral immune responses to spontaneous control of hepatitis C virus (HCV) infection remains unclear. We assessed neutralizing antibody (nAb) responses during acute HCV infection to determine whether infection outcome is associated with the nAb response, specifically, its timing or breadth (neutralization of multiple genotype‐matched variants).

Jae Ho Lee, Gha Young Lee, Hagoon Jang, Sung Sik Choe, Seung‐Hoi Koo, Jae Bum Kim – 15 January 2014 – Sterol regulatory element binding protein1c (SREBP1c) is a key transcription factor for de novo lipogenesis during the postprandial state. During nutritional deprivation, hepatic SREBP1c is rapidly suppressed by fasting signals to prevent lipogenic pathways. However, the molecular mechanisms that control SREBP1c turnover in response to fasting status are not thoroughly understood.

Stefano Romeo, Luca Valenti, Eric Trépo, Christophe Moreno, Pierre Nahon, Pierre Deltenre – 15 January 2014

Jia‐Hao Jiang, Yan‐Feng Liu, Ai‐Wu Ke, Fang‐Ming Gu, Yao Yu, Zhi Dai, Qiang Gao, Guo‐Ming Shi, Bo‐Yi Liao, You‐Hua Xie, Jia Fan, Xiao‐Wu Huang, Jian Zhou – 15 January 2014 – Virus‐induced hepatocarcinogenesis involves a series of histological developmental processes with the stepwise acquisition of several genetic changes that are necessary for the malignant transformation of hepatocytes. Although genetic alterations are known to be involved in the pathogenesis of hepatocellular carcinoma (HCC), little is known about the contributions of specific genes to this process.

Francesco Salerno, Valentina Monti – 15 January 2014

Sangbin Han, Justin Sangwook Ko, Gheeyoung Kwon, Cheolkeun Park, Sanghoon Lee, Jongman Kim, Gaabsoo Kim, Choonhyuck David Kwon, Misook Gwak, Sangyun Ha – 14 January 2014 – Liver steatosis mostly exists in a mixed form of macrosteatosis (MaS) and microsteatosis (MiS). This coexistence is responsible for previous conflicting results regarding the importance of MiS in liver transplantation. We aimed to evaluate the independent effect of MiS on posttransplant outcomes with the exclusion of the confounding effect of MaS.

Toru Ikegami, Yuki Bekki, Daisuke Imai, Tomoharu Yoshizumi, Mizuki Ninomiya, Hiromitsu Hayashi, Yo‐Ichi Yamashita, Hideaki Uchiyama, Ken Shirabe, Yoshihiko Maehara – 14 January 2014 – The purpose of this study was to determine the outcomes of living donor liver transplantation (LDLT) for elderly recipients. We reviewed 411 adult‐to‐adult LDLT cases, including 46 recipients who were 65 years old or older and 365 recipients who were less than 65 years old.

Manuel Mendizabal, Sebastián Marciano, María G. Videla, Margarita Anders, Alina Zerega, Domingo C. Balderramo, Débora Chan, Martín Barrabino, Octavio Gil, Ricardo Mastai, Silvina Yantorno, Adrián Gadano, Marcelo O. Silva – 14 January 2014 – There is significant geographic variation in the etiologies and prognoses of acute liver failure (ALF). The aims of the present study were to determine the causes and short‐term outcomes of ALF in Argentina, to evaluate the performance of prognostic criteria, and to identify clinical prognostic factors of death.

Marianna Hösel, Julie Lucifora, Thomas Michler, Gisela Holz, Marion Gruffaz, Stephanie Stahnke, Fabien Zoulim, David Durantel, Mathias Heikenwalder, Dirk Nierhoff, Rachel Millet, Anna Salvetti, Ulrike Protzer, Hildegard Büning – 14 January 2014 – Gene therapy has become an accepted concept for the treatment of a variety of different diseases. In contrast to preclinical models, subjects enrolled in clinical trials, including gene therapy, possess a history of infection with microbes that may influence its safety and efficacy.